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B. Brett Finlay
Researcher at University of British Columbia
Publications - 609
Citations - 69318
B. Brett Finlay is an academic researcher from University of British Columbia. The author has contributed to research in topics: Virulence & Effector. The author has an hindex of 135, co-authored 588 publications receiving 61894 citations. Previous affiliations of B. Brett Finlay include Vaccine and Infectious Disease Organization & Canadian Institute for Advanced Research.
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Journal ArticleDOI
Regulation of Type III Secretion Hierarchy of Translocators and Effectors in Attaching and Effacing Bacterial Pathogens
Wanyin Deng,Yuling Li,Philip R. Hardwidge,Elizabeth A. Frey,Richard A. Pfuetzner,Sansan Lee,Samantha Gruenheid,Natalie C. J. Strynakda,José L. Puente,B. Brett Finlay +9 more
TL;DR: The results suggest that SepL and SepD not only are necessary for efficient translocator secretion in A/E pathogens but also control a switch from translocators to effector secretion by sensing certain environmental signals such as low calcium.
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Salmonella effectors within a single pathogenicity island are differentially expressed and translocated by separate type III secretion systems.
Leigh A. Knodler,Jean Celli,Wolf-Dietrich Hardt,Bruce A. Vallance,Calvin K. Yip,B. Brett Finlay +5 more
TL;DR: A functional and regulatory cross‐talk between three chromosomal PAIs, SPI‐1, SPI-2 and SPI‐5, has significant implications for the evolution and role of PAIs in bacterial pathogenesis.
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Salmonella type III effectors PipB and PipB2 are targeted to detergent-resistant microdomains on internal host cell membranes.
Leigh A. Knodler,Bruce A. Vallance,Michael Hensel,Daniela Jäckel,B. Brett Finlay,Olivia Steele-Mortimer +5 more
TL;DR: A new Salmonella effector is described, PipB2, which has sequence similarity to another type III effector, pipB, which is enriched in detergent‐resistant microdomains (DRMs) present on membranes of SCVs and Sifs.
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M cells and the pathogenesis of mucosal and systemic infections
Annette Siebers,B. Brett Finlay +1 more
TL;DR: M cells are specialized epithelial cells of mucosal surfaces lining the respiratory and intestinal tracts that participate in generating mucosal immune protection by sampling and delivering antigens to the underlying lymphoid tissue.
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Analysis of the Contribution of Salmonella Pathogenicity Islands 1 and 2 to Enteric Disease Progression Using a Novel Bovine Ileal Loop Model and a Murine Model of Infectious Enterocolitis
Brian K. Coombes,Bryan Coburn,Andrew A. Potter,Susantha Gomis,Kuldip K. Mirakhur,Yuling Li,B. Brett Finlay +6 more
TL;DR: A novel ileal loop model is developed for use in calves to analyze the contribution of Salmonella enterica serovar Typhimurium type III secretion systems to disease processes in vivo and delineate novel phenotypes for SPI-1 and SPI-2 mutants in the intestinal phase of bovine and murine salmonellosis.