B
B. Brett Finlay
Researcher at University of British Columbia
Publications - 609
Citations - 69318
B. Brett Finlay is an academic researcher from University of British Columbia. The author has contributed to research in topics: Virulence & Effector. The author has an hindex of 135, co-authored 588 publications receiving 61894 citations. Previous affiliations of B. Brett Finlay include Vaccine and Infectious Disease Organization & Canadian Institute for Advanced Research.
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Trafficking of Porin-Deficient Salmonella typhimurium Mutants inside HeLa Cells: ompR and envZ Mutants Are Defective for the Formation of Salmonella-Induced Filaments
TL;DR: OmpR and EnvZ appear to regulate Sif formation triggered by intracellular S. typhimurium, and genetic analysis showed that the ompR mutation could be complemented intrans by cloned OmpR to restore its ability to induce Sifs.
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Antivirulence Activity of the Human Gut Metabolome
L. Caetano M. Antunes,L. Caetano M. Antunes,Julie A. K. McDonald,Kathleen Schroeter,Christian Carlucci,Rosana B. R. Ferreira,Melody Wang,Sophie Yurist-Doutsch,Gill Hira,Kevan Jacobson,Julian Davies,Emma Allen-Vercoe,B. Brett Finlay +12 more
TL;DR: A secreted molecule produced by clostridia acts as a strong repressor of Salmonella virulence, obliterating expression of the Salmoneella pathogenicity island 1 as well as host cell invasion, suggesting that chemical sensing may be involved in this phenomenon.
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Renaming protein secretion in the Gram-negative bacteria
Ian R. Henderson,James P. Nataro,James B. Kaper,Thomas F. Meyer,Stephen K. Farrand,Drusilla L. Burns,B. Brett Finlay,Joseph W. St. Geme +7 more
TL;DR: It is proposed that the type IV nomenclature of these secretion mechanisms be reserved for the Ptl and homologous systems found in A. tumefaciens and other Gram-negative bacteria.
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Metabolomics: towards understanding host–microbe interactions
TL;DR: This integrated, systems biology approach is improving the understanding of the molecular mechanisms underlying multilevel host-microbe interactions, and promises to elucidate the etiologies of human disorders resulting from unfavorable human-microbial associations, including enteric infections.
Journal Article
Intracellular replication of Salmonella within epithelial cells is associated with filamentous structures containing lysosomal membrane glycoproteins.
TL;DR: Kinetics analysis showed a strict correlation between the appearance of these LGP-rich filaments and the initiation of intracellular bacterial replication, and additional data confirmed that an intact microtubule network and intravacuolar acidic pH are required to induce the formation of L GP-containing filamentous structures.