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B. Brett Finlay
Researcher at University of British Columbia
Publications - 609
Citations - 69318
B. Brett Finlay is an academic researcher from University of British Columbia. The author has contributed to research in topics: Virulence & Effector. The author has an hindex of 135, co-authored 588 publications receiving 61894 citations. Previous affiliations of B. Brett Finlay include Vaccine and Infectious Disease Organization & Canadian Institute for Advanced Research.
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Journal ArticleDOI
The role of dynamin 3 in the testis.
Kuljeet Vaid,Julian A. Guttman,N. Babyak,Wanyin Deng,Mark A. McNiven,N. Mochizuki,B. Brett Finlay,A. W. Vogl +7 more
TL;DR: Dynamin 3 in the testis is associated with structures termed tubulobulbar complexes that internalize intact intercellular junctions during sperm release and turnover of the blood–testis barrier and occurs in concentrated deposits around the capitulum and striated columns in the connecting piece of sperm tails.
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Diversity and dynamism of IgA-microbiota interactions.
TL;DR: IgA mediates microbial homeostasis at the intestinal mucosa within the gut, IgA acts in a context-dependent manner to both prevent and promote bacterial colonization and to influence bacterial gene expression, thus providing exquisite control of the microbiota as discussed by the authors.
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Mapping the protein interaction network in methicillin-resistant Staphylococcus aureus
Artem Cherkasov,Artem Cherkasov,Michael Hsing,Roya Zoraghi,Leonard J. Foster,Raymond H. See,Nikolay Stoynov,Jihong Jiang,Sukhbir Kaur,Tian Lian,Linda A. Jackson,Huansheng Gong,Rick Swayze,Emily Amandoron,Farhad Hormozdiari,Phuong Dao,Cenk Sahinalp,Osvaldo A. Santos-Filho,Peter Axerio-Cilies,Kendall G. Byler,William R. McMaster,Robert C. Brunham,B. Brett Finlay,Neil E. Reiner +23 more
TL;DR: This empirical MRSA-252 PIN provides a rich source for identifying critical proteins essential for network stability, many of which can be considered as prospective antimicrobial drug targets.
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Salmonella Phage ST64B Encodes a Member of the SseK/NleB Effector Family
Nathaniel Francis Brown,Nathaniel Francis Brown,Brian K. Coombes,Jenna L. Bishop,Mark Wickham,Michael J. Lowden,Ohad Gal-Mor,David L Goode,Erin C. Boyle,Kristy L. Sanderson,B. Brett Finlay +10 more
TL;DR: SseK3 and other phage-encoded effectors were found to have a significant but sparse distribution in the available Salmonella genome sequences, indicating the potential for more uncharacterised effectors to be present in less studied serovars.
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From ingestion to colonization: the influence of the host environment on regulation of the LEE encoded type III secretion system in enterohaemorrhagic Escherichia coli.
TL;DR: Regulation of the LEE is discussed, focusing on how physiologically relevant signals are sensed and how they affect the expression of this major virulence factor.