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B. Brett Finlay
Researcher at University of British Columbia
Publications - 609
Citations - 69318
B. Brett Finlay is an academic researcher from University of British Columbia. The author has contributed to research in topics: Virulence & Effector. The author has an hindex of 135, co-authored 588 publications receiving 61894 citations. Previous affiliations of B. Brett Finlay include Vaccine and Infectious Disease Organization & Canadian Institute for Advanced Research.
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Journal ArticleDOI
Cryo-EM structure of the EspA filament from enteropathogenic Escherichia coli: Revealing the mechanism of effector translocation in the T3SS.
Bronwyn Lyons,Claire E. Atkinson,Wanyin Deng,Antonio Serapio-Palacios,B. Brett Finlay,Natalie C. J. Strynadka +5 more
TL;DR: In this article, the authors describe the structure of the EspA filament from the enteropathogenic Escherichia coli (EPEC) at 3.6-A resolution, showing positively charged residues adjacent to a hydrophobic groove line the lumen of the filament in a spiral manner.
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Differences in the fecal microbiota of dairy calves reared with differing sources of milk and levels of maternal contact
Annabelle Beaver,Annabelle Beaver,Charisse Petersen,Daniel M. Weary,B. Brett Finlay,Marina A.G. von Keyserlingk +5 more
TL;DR: Preliminary evidence of the effects of early rearing environments on the establishment of the dairy calf fecal microbiota is provided, given the critical role of the bovine gut microbiome in behavioral, metabolic, and immune development.
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Early-life cytomegalovirus infection is associated with gut microbiota perturbations and increased risk of atopy.
Hind Sbihi,Hind Sbihi,Karen E. Simmons,Malcolm R. Sears,Theo J Moraes,Allan B. Becker,Piush J. Mandhane,Padmaja Subbarao,Darlene L.Y. Dai,B. Brett Finlay,Stuart E. Turvey,Soren Gantt +11 more
TL;DR: Early-life CMV infection is associated with an alteration in the intestinal microbiota, which mediates the effect of the infection on childhood atopy, and a CMV vaccine, in addition to preventing CMV-associated morbidity and mortality, might reduce the risk of childhood allergic diseases.
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Structural and Cellular Insights into the l,d-Transpeptidase YcbB as a Therapeutic Target in Citrobacter rodentium, Salmonella Typhimurium, and Salmonella Typhi Infections.
Nathanael A. Caveney,Antonio Serapio-Palacios,Sarah E Woodward,Tahereh Bozorgmehr,G. Caballero,Marija Vuckovic,Wanyin Deng,B. Brett Finlay,Natalie C. J. Strynadka +8 more
TL;DR: Cumulatively, this work provides a foundation for the development of novel YcbB-specific antibacterial therapeutics to assist in treatment of increasingly drug-resistant S. Typhi infections.
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Dietary Intervention Reverses Fatty Liver and Altered Gut Microbiota during Early-Life Undernutrition.
Kylynda C. Bauer,Kelsey E. Huus,Eric M. Brown,Tahereh Bozorgmehr,Charisse Petersen,Mihai Cirstea,Sarah E Woodward,J. McCoy,J. Hun,Reinald Pamplona,Victoria Ayala,B. Brett Finlay +11 more
TL;DR: Exposure to specific gut microbes impacts fatty liver pathology in mice fed a protein/fat-deficient diet, indicating a crucial window in early-life development that, when disrupted by nutritional deficiency, may significantly influence liver function.