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B. Brett Finlay
Researcher at University of British Columbia
Publications - 609
Citations - 69318
B. Brett Finlay is an academic researcher from University of British Columbia. The author has contributed to research in topics: Virulence & Effector. The author has an hindex of 135, co-authored 588 publications receiving 61894 citations. Previous affiliations of B. Brett Finlay include Vaccine and Infectious Disease Organization & Canadian Institute for Advanced Research.
Papers
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Journal ArticleDOI
Combating enteropathogenic Escherichia coli (EPEC) infections: the way forward.
TL;DR: Increased efforts at diagnosis, defining the clinical spectrum of disease, understanding pathogenic mechanisms, and delineating immune responses are desperately needed to develop new strategies to combat EPEC.
Journal ArticleDOI
Characterization of the NleF effector protein from attaching and effacing bacterial pathogens.
Frank J. Echtenkamp,Wanyin Deng,Mark Wickham,Alejandra Vázquez,José L. Puente,Ajitha Thanabalasuriar,Samantha Gruenheid,B. Brett Finlay,Philip R. Hardwidge +8 more
TL;DR: Immunoblotting of secreted and translocated proteins suggest that NleF is secreted by the T3SS and is translocated into host cells in vitro where it localizes to the host cytoplasm.
Book ChapterDOI
Inhibitors of cytoskeletal function and signal transduction to study bacterial invasion.
TL;DR: This chapter discusses the inhibitors of cytoskeletal function and signal transduction to study bacterial invasion, and how agents are becoming available that inhibit these various enzymes can be used to probe whether bacterial invasion involves a host kinase.
Journal ArticleDOI
Salmonella enterica serovar Typhimurium-induced placental inflammation and not bacterial burden correlates with pathology and fatal maternal disease.
Anindita Chattopadhyay,Nirmal Robinson,Nirmal Robinson,Jagdeep K. Sandhu,Jagdeep K. Sandhu,B. Brett Finlay,Subash Sad,Subash Sad,Lakshmi Krishnan,Lakshmi Krishnan +9 more
TL;DR: The ability of Salmonella to localize to deeper layers of the placenta and the nature of inflammation triggered by the pathogen, rather than bacterial burden, profoundly influenced placental integrity and host survival.
Journal ArticleDOI
Oral infection of mice with Salmonella enterica serovar Typhimurium causes meningitis and infection of the brain
Mark Wickham,Mark Wickham,Nathaniel Francis Brown,Nathaniel Francis Brown,John Provias,B. Brett Finlay,Brian K. Coombes,Brian K. Coombes +7 more
TL;DR: This model may provide a system in which dissemination of bacteria through the central nervous system and the influence of host and bacterial genetics can be queried.