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B. Brett Finlay
Researcher at University of British Columbia
Publications - 609
Citations - 69318
B. Brett Finlay is an academic researcher from University of British Columbia. The author has contributed to research in topics: Virulence & Effector. The author has an hindex of 135, co-authored 588 publications receiving 61894 citations. Previous affiliations of B. Brett Finlay include Vaccine and Infectious Disease Organization & Canadian Institute for Advanced Research.
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Journal ArticleDOI
Global Profiling of Proteolysis from the Mitochondrial Amino Terminome during Early Intrinsic Apoptosis Prior to Caspase-3 Activation
Natalie C. Marshall,Theo Klein,Maichael Thejoe,Niklas von Krosigk,Jayachandran N. Kizhakkedathu,B. Brett Finlay,Christopher M. Overall +6 more
TL;DR: To examine the relatively unknown initial cleavage events occurring before the well-studied activation of caspase-3 in intrinsic apoptosis, this work quantitatively compared N-terminomes of mitochondria and their parent cells before and after initiation of apoptosis at very early time points.
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Repression of Salmonella Host Cell Invasion by Aromatic Small Molecules from the Human Fecal Metabolome.
Rafael José Marques Peixoto,Eduardo S. Alves,Melody Wang,Rosana B. R. Ferreira,Alessandra Granato,Jun Han,Hira Gill,Kevan Jacobson,Leandro Araujo Lobo,Regina Maria Cavalcanti Pilotto Domingues,Christoph H. Borchers,Julian Davies,B. Brett Finlay,L. Caetano M. Antunes,L. Caetano M. Antunes +14 more
TL;DR: An aromatic compound from the human gut acts as a strong inhibitor of hilA expression and of invasion of cultured host cells by Salmonella, and may represent an opportunity to develop drugs that can target these small-molecule interactions to protect us from enteric infections and other diseases.
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A Nonpyroptotic IFN-γ-Triggered Cell Death Mechanism in Nonphagocytic Cells Promotes Salmonella Clearance In Vivo.
Justin P. Ingram,Sarah A. Tursi,Ting Zhang,Wei Guo,Wei Guo,Chaoran Yin,Meghan A. Wynosky-Dolfi,Joris van der Heijden,Kathy Q. Cai,Masahiro Yamamoto,B. Brett Finlay,Igor E. Brodsky,Sergei I. Grivennikov,Çagla Tükel,Siddharth Balachandran +14 more
TL;DR: Exposing human and murine IECs and fibroblasts to IFN-γ following infection with Salmonella triggers a novel form of cell death that is neither pyroptosis nor any of the major known forms of programmed cell death, resulting in a form of nonpyroptotic cellDeath that prevents bacterial spread in the gut.
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Proteomic analysis of the binding partners to enteropathogenic Escherichia coli virulence proteins expressed in Saccharomyces cerevisiae.
TL;DR: To facilitate protein enrichment, fusions between GST and EPEC virulence proteins were created, and expressed these fusions individually in Saccharomyces cerevisiae, and the dataset suggests several potential mammalian targets of these proteins that may guide future experimentation.
Journal ArticleDOI
Gut Microbiota: Metagenomics to Study Complex Ecology
A. Vacharaksa,B. Brett Finlay +1 more
TL;DR: The microbial community of the gastrointestinal tract is large and complex, making it difficult to study; the recent development of techniques for metagenomic analysis of gut microbiota should be a boon to the field.