B
B. Brett Finlay
Researcher at University of British Columbia
Publications - 609
Citations - 69318
B. Brett Finlay is an academic researcher from University of British Columbia. The author has contributed to research in topics: Virulence & Effector. The author has an hindex of 135, co-authored 588 publications receiving 61894 citations. Previous affiliations of B. Brett Finlay include Vaccine and Infectious Disease Organization & Canadian Institute for Advanced Research.
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Characterization of Salmonella-induced filaments (Sifs) reveals a delayed interaction between Salmonella-containing vacuoles and late endocytic compartments.
TL;DR: It is demonstrated that Sif formation involves fusion of late endocytic compartments with the Salmonella‐containing vacuole, and suggested that S ifA modulates this event.
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Role of inflammasomes in host defense against Citrobacter rodentium infection.
Zhiping Liu,Md. Hasan Zaki,Peter Vogel,Prajwal Gurung,B. Brett Finlay,Wanyin Deng,Mohamed Lamkanfi,Thirumala-Devi Kanneganti +7 more
TL;DR: It is shown that mice lacking the inflammasome components Nlrp3, Nlrc4, and caspase-1 were hypersusceptible to C. rodentium-induced gastrointestinal inflammation, and production of IL-1β and IL-18 downstream of the NLRp3 and NlRC4 inflammaomes plays a critical role in host defense against enteric infections caused by C. rodentsium.
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Aquaporins contribute to diarrhoea caused by attaching and effacing bacterial pathogens.
TL;DR: It is demonstrated that during infection, AQP2 and AQP3 are mislocalized from their normal location along cell membranes to the cell cytoplasm, which correlates with the diarrhoea‐like phenotype present in infected mice.
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Enteropathogenic E. coli translocated intimin receptor, Tir, interacts directly with α-actinin
Danika L. Goosney,Rebekah DeVinney,Richard A. Pfuetzner,Elizabeth A. Frey,Natalie C. J. Strynadka,B. Brett Finlay +5 more
TL;DR: It is shown that Tir directly binds the cytoskeletal protein alpha-actinin, the first known direct linkage between extracellular EPEC, through the transmembrane protein Tir, to the host cell actin cytoskeleton via alpha- actinin.
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Breastmilk Feeding Practices Are Associated with the Co-Occurrence of Bacteria in Mothers' Milk and the Infant Gut: the CHILD Cohort Study.
Kelsey Fehr,Kelsey Fehr,Shirin Moossavi,Shirin Moossavi,Shirin Moossavi,Hind Sbihi,Rozlyn C.T. Boutin,Lars Bode,Bianca Robertson,Chloe Yonemitsu,Catherine J. Field,Allan B. Becker,Allan B. Becker,Allan B. Becker,Piushkumar J. Mandhane,Malcolm R. Sears,Ehsan Khafipour,Theo J. Moraes,Padmaja Subbarao,B. Brett Finlay,Stuart E. Turvey,Meghan B. Azad,Meghan B. Azad +22 more
TL;DR: It is shown that certain bacteria, including Streptococcus spp.