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B. Brett Finlay
Researcher at University of British Columbia
Publications - 609
Citations - 69318
B. Brett Finlay is an academic researcher from University of British Columbia. The author has contributed to research in topics: Virulence & Effector. The author has an hindex of 135, co-authored 588 publications receiving 61894 citations. Previous affiliations of B. Brett Finlay include Vaccine and Infectious Disease Organization & Canadian Institute for Advanced Research.
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Sigma(s)-Dependent carbon-starvation induction of pbpG (PBP 7) is required for the starvation-stress response in Salmonella enterica serovar Typhimurium.
William J. Kenyon,Kristy L. Nicholson,Bronislava Rezuchova,Dagmar Homerova,Francisco García-del Portillo,Francisco García-del Portillo,B. Brett Finlay,Mark J. Pallen,Jan Kormanec,Michael P. Spector +9 more
TL;DR: The stiC locus was identified as a C-starvation-inducible, sigma(S)-dependent locus required for a maximal SSR, an operon composed of the yohC (putative transport protein) and pbpG (penicillin-binding protein-7/8) genes that supports the dynamic overlapping and distinct nature of resistance pathways within the Salmonella SSR.
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Breaking the Stereotype: Virulence Factor–Mediated Protection of Host Cells in Bacterial Pathogenesis
TL;DR: The following discussion addresses the concept that increased virulence is not always beneficial to the pathogen, and moderating it to preserve host cells is a mechanism several pathogens use as part of their overall pathogenic strategy.
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Host-microbe interaction: Innate immunity cues virulence.
TL;DR: This video explains how Salmonella intestinal pathogens use the immune response that their host triggers to destroy them to enhance the expression of genes that mediate the pathogens' virulence.
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N-terminal conservation of putative type III secreted effectors of Salmonella typhimurium.
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Multiple Salmonella-pathogenicity island 2 effectors are required to facilitate bacterial establishment of its intracellular niche and virulence
TL;DR: It is shown that each of SIF biogenesis, intracellular SCV localization, intramacrophage replication, colonization, and virulence depends on the activities of multiple effectors, and the necessity to study T3SS2-secreted effectors as groups, rather than studies of individual effectors.