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Bernard E. Ebruke
Researcher at Medical Research Council
Publications - 42
Citations - 3290
Bernard E. Ebruke is an academic researcher from Medical Research Council. The author has contributed to research in topics: Pneumonia & Medicine. The author has an hindex of 20, co-authored 37 publications receiving 2207 citations. Previous affiliations of Bernard E. Ebruke include University of London.
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Journal ArticleDOI
Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2015: a systematic review and modelling study
Ting Shi,David A. McAllister,Katherine L. O'Brien,Eric A. F. Simões,Shabir A. Madhi,Bradford D. Gessner,Fernando P. Polack,Evelyn Balsells,Sozinho Acácio,Claudia Aguayo,Issifou Alassani,Asad Ali,Martin Antonio,Shally Awasthi,Juliet O. Awori,Eduardo Azziz-Baumgartner,Eduardo Azziz-Baumgartner,Henry C. Baggett,Vicky L. Baillie,Angel Balmaseda,Alfredo Barahona,Sudha Basnet,Sudha Basnet,Quique Bassat,Quique Bassat,Wilma Basualdo,Godfrey Bigogo,Louis Bont,Robert F. Breiman,W. Abdullah Brooks,W. Abdullah Brooks,Shobha Broor,Nigel Bruce,Dana Bruden,Philippe Buchy,Stuart Campbell,Phyllis Carosone-Link,Mandeep S. Chadha,James Chipeta,Monidarin Chou,Wilfrido Clara,Cheryl Cohen,Cheryl Cohen,Elizabeth de Cuellar,Duc Anh Dang,Budragchaagiin Dash-Yandag,Maria Deloria-Knoll,Mukesh Dherani,Tekchheng Eap,Bernard E. Ebruke,Marcela Echavarria,Carla Cecília de Freitas Lázaro Emediato,Rodrigo Fasce,Daniel R. Feikin,Luzhao Feng,Angela Gentile,Aubree Gordon,Doli Goswami,Doli Goswami,Sophie Goyet,Michelle J. Groome,Natasha B. Halasa,Siddhivinayak Hirve,Nusrat Homaira,Nusrat Homaira,Stephen R. C. Howie,Stephen R. C. Howie,Stephen R. C. Howie,Jorge Jara,Imane Jroundi,Cissy B. Kartasasmita,Najwa Khuri-Bulos,Karen L. Kotloff,Anand Krishnan,Romina Libster,Romina Libster,Olga Lopez,Marilla G. Lucero,Florencia Lución,Socorro Lupisan,Debora N. Marcone,John P. McCracken,Mario Mejia,Jennifer C. Moïsi,Joel M. Montgomery,David P. Moore,Cinta Moraleda,Jocelyn Moyes,Jocelyn Moyes,Patrick K. Munywoki,Patrick K. Munywoki,Kuswandewi Mutyara,Mark P. Nicol,D. James Nokes,D. James Nokes,Pagbajabyn Nymadawa,Maria Tereza da Costa Oliveira,Histoshi Oshitani,Nitin Pandey,Gláucia Paranhos-Baccalà,Lia Neu Phillips,Valentina Picot,Mustafizur Rahman,Mala Rakoto-Andrianarivelo,Zeba A Rasmussen,Barbara Rath,Annick Robinson,Candice Romero,Graciela Russomando,Vahid Salimi,Pongpun Sawatwong,Nienke M Scheltema,Brunhilde Schweiger,J. Anthony G. Scott,J. Anthony G. Scott,Phil Seidenberg,Kunling Shen,Rosalyn J. Singleton,Rosalyn J. Singleton,Viviana Sotomayor,Tor A. Strand,Tor A. Strand,Agustinus Sutanto,Mariam Sylla,Milagritos D. Tapia,Somsak Thamthitiwat,Elizabeth Thomas,Rafal Tokarz,Claudia Turner,Marietjie Venter,Sunthareeya Waicharoen,Jianwei Wang,Wanitda Watthanaworawit,Lay-Myint Yoshida,Hongjie Yu,Heather J. Zar,Harry Campbell,Harish Nair,Harish Nair +138 more
TL;DR: In this paper, the authors estimated the incidence and hospital admission rate of RSV-associated acute lower respiratory infection (RSV-ALRI) in children younger than 5 years stratified by age and World Bank income regions.
Journal ArticleDOI
Causes of severe pneumonia requiring hospital admission in children without HIV infection from Africa and Asia: the PERCH multi-country case-control study
Katherine L. O'Brien,Henry C. Baggett,W. Abdullah Brooks,Daniel R. Feikin,Laura L. Hammitt,Melissa M. Higdon,Stephen R. C. Howie,Maria Deloria Knoll,Karen L. Kotloff,Orin S. Levine,Shabir A. Madhi,David R. Murdoch,Christine Prosperi,J. Anthony G. Scott,Qiyuan Shi,Donald M. Thea,Zhenke Wu,Scott L. Zeger,Peter V. Adrian,Pasakorn Akarasewi,Trevor P. Anderson,Martin Antonio,Juliet O. Awori,Vicky L. Baillie,Charatdao Bunthi,James Chipeta,Mohammod Jobayer Chisti,Jane Crawley,Andrea DeLuca,Amanda J. Driscoll,Bernard E. Ebruke,Hubert P. Endtz,Nicholas Fancourt,Wei Fu,Doli Goswami,Michelle J. Groome,Meredith Haddix,Lokman Hossain,Yasmin Jahan,E Wangeci Kagucia,Alice Kamau,Ruth A. Karron,Sidi Kazungu,Nana Kourouma,Locadiah Kuwanda,Geoffrey Kwenda,Mengying Li,Eunice M. Machuka,Grant A. Mackenzie,Nasreen Mahomed,Susan A. Maloney,Jessica McLellan,Joanne L. Mitchell,David P. Moore,Susan C. Morpeth,Azwifarwi Mudau,Lawrence Mwananyanda,James Mwansa,Micah Silaba Ominde,Uma Onwuchekwa,Daniel E. Park,Julia Rhodes,Pongpun Sawatwong,Phil Seidenberg,Arifin Shamsul,Eric A. F. Simões,Seydou Sissoko,Somwe Wa Somwe,Samba O. Sow,Mamadou Sylla,Boubou Tamboura,Milagritos D. Tapia,Somsak Thamthitiwat,Aliou Toure,Nora L. Watson,Khalequ Zaman,Syed M. A. Zaman +76 more
TL;DR: Estimating causes of pneumonia in young African and Asian children, using novel analytical methods applied to clinical and microbiological findings, estimated that viruses accounted for 61·4% (95% credible interval [CrI] 57·3–65·6) of causes, whereas bacteria accounted for 27·3% (23·3-31·6).
Journal ArticleDOI
Effect of the introduction of pneumococcal conjugate vaccination on invasive pneumococcal disease in The Gambia: a population-based surveillance study
Grant A. Mackenzie,Grant A. Mackenzie,Philip C. Hill,David Jeffries,Ilias Hossain,Uchendu Uchendu,David Ameh,Malick Ndiaye,Oyedeji Adeyemi,Jayani Pathirana,Yekini Olatunji,Bade Abatan,Bilquees S Muhammad,Augustin E Fombah,Debasish Saha,Ian D. Plumb,Aliu Akano,Bernard E. Ebruke,Readon C. Ideh,Bankole Peter Kuti,Peter Githua,Emmanuel Olutunde,Ogochukwu Ofordile,Edward Green,Effua Usuf,Henry Badji,Usman N. Ikumapayi,Ahmad Manjang,Rasheed Salaudeen,E David Nsekpong,Sheikh Jarju,Martin Antonio,Martin Antonio,Martin Antonio,Sana Sambou,Lamin Ceesay,Yamundow Lowe-Jallow,Momodou Jasseh,Kim Mulholland,Maria Deloria Knoll,Orin S. Levine,Stephen R. C. Howie,Stephen R. C. Howie,Stephen R. C. Howie,Richard A. Adegbola,Brian Greenwood,Tumani Corrah +46 more
TL;DR: The Gambian PCV programme reduced the incidence of invasive pneumococcal disease in children aged 2–59 months by around 55% and further surveillance is needed to ascertain the maximum effect of the vaccine in the 2–4 years and older age groups, and to monitor serotype replacement.
Journal ArticleDOI
Impact of the introduction of pneumococcal conjugate vaccination on pneumonia in The Gambia: population-based surveillance and case-control studies.
Grant A. Mackenzie,Grant A. Mackenzie,Philip C. Hill,Shah M Sahito,David Jeffries,Ilias Hossain,Christian Bottomley,Uchendu Uchendu,David Ameh,Malick Ndiaye,Chidebereh D Osuorah,Oyedeji Adeyemi,Jayani Pathirana,Yekini Olatunji,Bade Abatan,Ebirim Ahameefula,Bilquees S Muhammad,Augustin E Fombah,Debasish Saha,Roslyn Mackenzie,Ian D. Plumb,Aliu Akano,Bernard E. Ebruke,Readon C. Ideh,Bankole Peter Kuti,Peter Githua,Emmanuel Olutunde,Ogochukwu Ofordile,Edward Green,Effua Usuf,Henry Badji,Usman N. Ikumapayi,Ahmad Manjang,Rasheed Salaudeen,E David Nsekpong,Sheikh Jarju,Martin Antonio,Martin Antonio,Sana Sambou,Lamin Ceesay,Yamundow Lowe-Jallow,Dawda Sowe,Momodou Jasseh,Kim Mulholland,Maria Deloria Knoll,Orin S. Levine,Stephen R. C. Howie,Stephen R. C. Howie,Stephen R. C. Howie,Richard A. Adegbola,Brian Greenwood,Tumani Corrah +51 more
TL;DR: The introduction of PCV in The Gambia was associated with a moderate impact on the incidence of radiological pneumonia, a small reduction in cases of hospitalised pneumonia, and substantial reductions of pneumococcal and hypoxic pneumonia in young children.
Journal ArticleDOI
Density of Upper Respiratory Colonization With Streptococcus pneumoniae and Its Role in the Diagnosis of Pneumococcal Pneumonia Among Children Aged <5 Years in the PERCH Study
Henry C. Baggett,Nora L. Watson,Maria Deloria Knoll,W. Abdullah Brooks,W. Abdullah Brooks,Daniel R. Feikin,Laura L. Hammitt,Stephen R. C. Howie,Stephen R. C. Howie,Stephen R. C. Howie,Karen L. Kotloff,Orin S. Levine,Shabir A. Madhi,Shabir A. Madhi,David R. Murdoch,David R. Murdoch,J. Anthony G. Scott,J. Anthony G. Scott,Donald M. Thea,Martin Antonio,Martin Antonio,Martin Antonio,Juliet O. Awori,Vicky L. Baillie,Vicky L. Baillie,Andrea DeLuca,Amanda J. Driscoll,Julie Duncan,Bernard E. Ebruke,Doli Goswami,Melissa M. Higdon,Ruth A. Karron,David P. Moore,David P. Moore,Susan C. Morpeth,Susan C. Morpeth,Susan C. Morpeth,Justin M Mulindwa,Daniel E. Park,Wantana Paveenkittiporn,Barameht Piralam,Christine Prosperi,Samba O. Sow,Milagritos D. Tapia,Khalequ Zaman,Scott L. Zeger,Katherine L. O'Brien,Nicholas Fancourt,Wei Fu,E Wangeci Kagucia,Mengying Li,Zhenke Wu,Jane Crawley,Hubert P. Endtz,Lokman Hossain,Yasmin Jahan,Hasan Ashraf,Jessica McLellan,Eunice Machuka,Arifin Shamsul,Syed M. A. Zaman,Grant A. Mackenzie,Alice Kamau,Sidi Kazungu,Micah Silaba Ominde,Mamadou Sylla,Boubou Tamboura,Uma Onwuchekwa,Nana Kourouma,Aliou Toure,Peter V. Adrian,Locadiah Kuwanda,Azwifarwi Mudau,Michelle J. Groome,Nasreen Mahomed,Somsak Thamthitiwat,Susan A. Maloney,Charatdao Bunthi,Julia Rhodes,Pongpun Sawatwong,Pasakorn Akarasewi,Lawrence Mwananyanda,James Chipeta,Phil Seidenberg,James Mwansa,Somwe Wa Somwe,Geoffrey Kwenda,Trevor P. Anderson,Joanne L. Mitchell +88 more
TL;DR: Upper airway pneumococcal colonization density among children hospitalized with World Health Organization–defined pneumonia was associated with microbiologically confirmed pneumococCal pneumonia (MCPP) and the optimal colonization density threshold was ≥7 log10 copies/mL.