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Chien Te K. Tseng
Researcher at University of Texas Medical Branch
Publications - 80
Citations - 8185
Chien Te K. Tseng is an academic researcher from University of Texas Medical Branch. The author has contributed to research in topics: Coronavirus & Antibody. The author has an hindex of 43, co-authored 71 publications receiving 6267 citations.
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Journal ArticleDOI
Animal models for COVID-19.
César Muñoz-Fontela,William E. Dowling,Simon G. P. Funnell,Pierre Stéphane Gsell,A. Ximena Riveros-Balta,Randy A. Albrecht,Hanne Leth Andersen,Ralph S. Baric,Miles W. Carroll,Marco Cavaleri,Chuan Qin,Ian Crozier,Kai Dallmeier,Leon de Waal,Emmie de Wit,Leen Delang,Erik D. Dohm,W. Paul Duprex,Darryl Falzarano,Courtney L. Finch,Matthew B. Frieman,Barney S. Graham,Lisa E. Gralinski,Kate Guilfoyle,Bart L. Haagmans,Geraldine A. Hamilton,Amy L. Hartman,Sander Herfst,Suzanne J.F. Kaptein,William B. Klimstra,Ivana Knezevic,Philip R. Krause,Jens H. Kuhn,Roger Le Grand,Mark G. Lewis,Wen-Chun Liu,Pauline Maisonnasse,Anita K. McElroy,Vincent J. Munster,Nadia Oreshkova,Angela L. Rasmussen,Joana Rocha-Pereira,Barry Rockx,Estefanía Rodríguez,Thomas F. Rogers,Francisco J. Salguero,Michael Schotsaert,Koert J. Stittelaar,Hendrik Jan Thibaut,Chien Te K. Tseng,Júlia Vergara-Alert,Martin Beer,Trevor Brasel,Jasper Fuk-Woo Chan,Adolfo García-Sastre,Johan Neyts,Stanley Perlman,Douglas S. Reed,Juergen A. Richt,Chad J. Roy,Joaquim Segalés,Seshadri S. Vasan,Seshadri S. Vasan,Ana Maria Henao-Restrepo,Dan H. Barouch +64 more
TL;DR: The findings of a World Health Organization expert working group that is developing animal models to test vaccines and therapeutic agents for the treatment of COVID-19, and their relevance for preclinical testing, are reviewed.
Journal ArticleDOI
Immunization with SARS Coronavirus Vaccines Leads to Pulmonary Immunopathology on Challenge with the SARS Virus
Chien Te K. Tseng,Elena Sbrana,Naoko Iwata-Yoshikawa,Patrick C. Newman,Tania Garron,Robert L. Atmar,Clarence J. Peters,Robert B. Couch +7 more
TL;DR: These SARS-CoV vaccines all induced antibody and protection against infection with SARS -CoV, however, challenge of mice given any of the vaccines led to occurrence of Th2-type immunopathology suggesting hypersensitivity to SARsCoV components was induced.
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Binding of the Hepatitis C Virus Envelope Protein E2 to CD81 Inhibits Natural Killer Cell Functions
TL;DR: It is shown that CD81 cross-linking via immobilized E2 or mAbs specific for CD81 inhibits not only non major histocompatibility complex–restricted cytotoxicity mediated byNK cells but also interferon (IFN)-γ production by NK cells after exposure to interleukin (IL)-2, IL-12,IL-15, or CD16 cross- linking.
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Severe Acute Respiratory Syndrome Coronavirus nsp1 Suppresses Host Gene Expression, Including That of Type I Interferon, in Infected Cells
Krishna Narayanan,Cheng Huang,Kumari G. Lokugamage,Wataru Kamitani,Tetsuro Ikegami,Chien Te K. Tseng,Shinji Makino +6 more
TL;DR: It is demonstrated that SARS-CoV nsp1 suppressed host innate immune functions, including type I IFN expression, in infected cells and suggested that Sars- CoV nSp1 most probably plays a critical role in SARS -CoV virulence.
Journal ArticleDOI
A pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike
Shuai Xia,Lei Yan,Wei Xu,Anurodh S. Agrawal,Abdullah Algaissi,Abdullah Algaissi,Chien Te K. Tseng,Qian Wang,Lanying Du,Wenjie Tan,Ian A. Wilson,Ian A. Wilson,Shibo Jiang,Shibo Jiang,Bei Yang,Lu Lu +15 more
TL;DR: Crystal structures indicated that EK1 can form a stable six-helix bundle structure with both short α-HCoV and long β-H CoV HR1s, further supporting the role of HR1 region as a viable pan-CoV target site.