E
Ed Saunders
Researcher at Institute of Cancer Research
Publications - 24
Citations - 2910
Ed Saunders is an academic researcher from Institute of Cancer Research. The author has contributed to research in topics: Prostate cancer & Genome-wide association study. The author has an hindex of 13, co-authored 17 publications receiving 2501 citations.
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Journal ArticleDOI
Germline BRCA Mutations Are Associated With Higher Risk of Nodal Involvement, Distant Metastasis, and Poor Survival Outcomes in Prostate Cancer
Elena Castro,Chee Goh,David Olmos,Ed Saunders,Daniel Leongamornlert,Malgorzata Tymrakiewicz,N. Mahmud,Tokhir Dadaev,Koveela Govindasami,Michelle Guy,Emma J. Sawyer,Rosemary A. Wilkinson,Audrey Ardern-Jones,Steve Ellis,Debra Frost,Susan Peock,D. Gareth Evans,Marc Tischkowitz,Trevor Cole,Rosemarie Davidson,Diana Eccles,Carole Brewer,Fiona Douglas,Mary Porteous,Alan Donaldson,Huw Dorkins,Louise Izatt,Jackie Cook,Shirley Hodgson,M. John Kennedy,Lucy Side,Jacqueline Eason,Alex Murray,Antonis C. Antoniou,Douglas F. Easton,Zsofia Kote-Jarai,Rosalind A. Eeles +36 more
TL;DR: It is confirmed that BRCA1/2 mutations confer a more aggressive PCa phenotype with a higher probability of nodal involvement and distant metastasis and this should be considered for tailoring clinical management of these patients.
Journal ArticleDOI
A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer
Ali Amin Al Olama,Zsofia Kote-Jarai,Sonja I. Berndt,David V. Conti,Fredrick R. Schumacher,Ying Han,Sara Benlloch,Dennis J. Hazelett,Zhaoming Wang,Ed Saunders,Daniel Leongamornlert,Sara Lindström,Sara Jugurnauth-Little,Tokhir Dadaev,Malgorzata Tymrakiewicz,Daniel O. Stram,Kristin A. Rand,Peggy Wan,Alex Stram,Xin Sheng,Loreall Pooler,Karen Park,Lucy Xia,Jonathan Tyrer,Laurence N. Kolonel,Loic Le Marchand,Robert N. Hoover,Mitchell J. Machiela,Merideth Yeager,Laurie Burdette,Charles C. Chung,Amy K. Hutchinson,Kai Yu,Chee Goh,Mahbubl Ahmed,Koveela Govindasami,Michelle Guy,Teuvo L.J. Tammela,Anssi Auvinen,Tiina Wahlfors,Johanna Schleutker,Tapio Visakorpi,Katri A. Leinonen,Jianfeng Xu,Markus Aly,Jenny L Donovan,Ruth C. Travis,Timothy J. Key,Afshan Siddiq,Federico Canzian,Kay-Tee Khaw,Atsushi Takahashi,Michiaki Kubo,Paul D.P. Pharoah,Nora Pashayan,Maren Weischer,Børge G. Nordestgaard,Sune F. Nielsen,Peter Klarskov,Martin Andreas Røder,Peter Iversen,Stephen N. Thibodeau,Shannon K. McDonnell,Daniel J. Schaid,Janet L. Stanford,Janet L. Stanford,Suzanne Kolb,Sarah K. Holt,Beatrice S. Knudsen,Antonio Hurtado Coll,Susan M. Gapstur,W. Ryan Diver,Victoria L. Stevens,Christiane Maier,Manuel Luedeke,Kathleen Herkommer,Antje E. Rinckleb,Sara S. Strom,Curtis A. Pettaway,Edward D. Yeboah,Edward D. Yeboah,Yao Tettey,Yao Tettey,Richard B. Biritwum,Richard B. Biritwum,Andrew A. Adjei,Andrew A. Adjei,Evelyn Tay,Evelyn Tay,Ann Truelove,Shelley Niwa,Anand P. Chokkalingam,Lisa A. Cannon-Albright,Lisa A. Cannon-Albright,Cezary Cybulski,Dominika Wokołorczyk,Wojciech Kluźniak,Jong Y. Park,Thomas A. Sellers,Hui-Yi Lin,William B. Isaacs,Alan W. Partin,Hermann Brenner,Aida Karina Dieffenbach,Christa Stegmaier,Constance Chen,Edward Giovannucci,Jing Ma,Meir J. Stampfer,Kathryn L. Penney,Lorelei A. Mucci,Esther M. John,Esther M. John,Sue A. Ingles,Rick A. Kittles,Adam B. Murphy,Hardev Pandha,Agnieszka Michael,Andrzej M. Kierzek,William J. Blot,Lisa B. Signorello,Wei Zheng,Demetrius Albanes,Jarmo Virtamo,Stephanie J. Weinstein,Barbara Nemesure,John D. Carpten,Cristina Leske,Suh-Yuh Wu,Anselm Hennis,Anselm Hennis,Adam S. Kibel,Benjamin A. Rybicki,Christine Neslund-Dudas,Ann W. Hsing,Ann W. Hsing,Lisa Chu,Lisa Chu,Phyllis J. Goodman,Eric A. Klein,S. Lilly Zheng,Jyotsna Batra,Judith A. Clements,Amanda B. Spurdle,Manuel R. Teixeira,Manuel R. Teixeira,Paula Paulo,Sofia Maia,Chavdar Slavov,Radka Kaneva,Vanio Mitev,John S. Witte,Graham Casey,Elizabeth M. Gillanders,Daniella Seminara,Elio Riboli,Freddie C. Hamdy,Gerhard A. Coetzee,Qiyuan Li,Matthew L. Freedman,David J. Hunter,Kenneth Muir,Kenneth Muir,Henrik Grönberg,David E. Neal,David E. Neal,Melissa C. Southey,Graham G. Giles,Graham G. Giles,Gianluca Severi,Gianluca Severi,Michael B. Cook,Hidewaki Nakagawa,Fredrik Wiklund,Peter Kraft,Stephen J. Chanock,Brian E. Henderson,Douglas F. Easton,Rosalind A. Eeles,Christopher A. Haiman +179 more
TL;DR: These findings provide new regions for investigation into the pathogenesis of prostate cancer and demonstrate the usefulness of combining ancestrally diverse populations to discover risk loci for disease.
Journal ArticleDOI
BRCA2 is a moderate penetrance gene contributing to young-onset prostate cancer: implications for genetic testing in prostate cancer patients
Zsofia Kote-Jarai,Daniel Leongamornlert,Ed Saunders,Malgorzata Tymrakiewicz,Elena Castro,N. Mahmud,Michelle Guy,S Edwards,S Edwards,Lynne T. O'Brien,Emma J. Sawyer,Amanda L. Hall,Rosemary A. Wilkinson,Tokhir Dadaev,Chee L. Goh,Doug Easton,David E. Goldgar,Rosalind A. Eeles,Rosalind A. Eeles +18 more
TL;DR: It is estimated that germline mutations in the BRCA2 gene confer an ∼8.6-fold increased risk of PrCa by age 65, corresponding to an absolute risk of ∼15% by age65.
Journal ArticleDOI
Multiple Loci on 8q24 Associated With Prostate Cancer Susceptibility
Ali Amin Al Olama,Zsofia Kote-Jarai,Graham G. Giles,Graham G. Giles,Michelle Guy,Jonathan J. Morrison,Gianluca Severi,Gianluca Severi,Daniel Leongamornlert,Malgorzata Tymrakiewicz,Sameer Jhavar,Ed Saunders,John L. Hopper,Melissa C. Southey,Kenneth Muir,Dallas R. English,David P. Dearnaley,David P. Dearnaley,Audrey Ardern-Jones,Amanda L. Hall,Amanda L. Hall,Lynne T. O'Brien,Rosemary A. Wilkinson,Emma J. Sawyer,Artitaya Lophatananon,UK Prostate testing for cancer,UK Prostate testing for cancer,Alan Horwich,Alan Horwich,Robert Huddart,Robert Huddart,Vincent Khoo,Vincent Khoo,Chris Parker,Chris Parker,C. R. J. Woodhouse,Alan Thompson,Tim Christmas,Chris Ogden,Colin Cooper,Jenny L Donovan,Freddie C. Hamdy,David E. Neal,Rosalind A. Eeles,Rosalind A. Eeles,Douglas F. Easton +45 more
TL;DR: Eight SNPs in five linkage disequilibrium blocks were independently associated with prostate cancer susceptibility and confirmed associations at three previously reported loci.
Journal ArticleDOI
Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study
Zsofia Kote-Jarai,Olama Aaa.,G.G. Giles,G.G. Giles,Gianluca Severi,Gianluca Severi,Johanna Schleutker,Maren Weischer,Daniele Campa,Elio Riboli,Timothy J. Key,Henrik Grönberg,David J. Hunter,Peter Kraft,Michael J. Thun,Sue A. Ingles,Stephen J. Chanock,Stephen J. Chanock,Demetrius Albanes,Richard B. Hayes,David E. Neal,David E. Neal,Freddie C. Hamdy,Jenny L Donovan,Paul D.P. Pharoah,Fredrick R. Schumacher,Brian E. Henderson,Janet L. Stanford,Janet L. Stanford,Elaine A. Ostrander,Karina Dalsgaard Sørensen,Thilo Dörk,Gerald L. Andriole,Joanne L. Dickinson,Cezary Cybulski,Jan Lubinski,Amanda B. Spurdle,Judith A. Clements,Suzanne K. Chambers,Joanne F. Aitken,Gardiner Raf.,S. N. Thibodeau,D J Schaid,Esther M. John,Esther M. John,Christiane Maier,W. Vogel,Kathleen A. Cooney,Jong Y. Park,Lisa A. Cannon-Albright,Lisa A. Cannon-Albright,Hermann Brenner,Tomonori Habuchi,Zhang H-W.,Lu Y-J.,Radka Kaneva,Kenneth Muir,Sara Benlloch,Daniel Leongamornlert,Ed Saunders,Malgorzata Tymrakiewicz,N. Mahmud,Michelle Guy,Lynne T. O'Brien,R A Wilkinson,Amanda L. Hall,E J Sawyer,Tokhir Dadaev,Jonathan J. Morrison,David P. Dearnaley,David P. Dearnaley,Alan Horwich,Alan Horwich,Robert Huddart,Robert Huddart,Vincent Khoo,Vincent Khoo,Chris Parker,Chris Parker,N. van As,C.R.J. Woodhouse,A. Thompson,Timothy J. Christmas,Chris Ogden,Colin Cooper,Aritaya Lophatonanon,Melissa C. Southey,John L. Hopper,Dallas R. English,Dallas R. English,T. Wahlfors,Tammela Tlj.,Peter Klarskov,Børge G. Nordestgaard,Martin Andreas Røder,Anne Tybjærg-Hansen,Stig E. Bojesen,Ruth C. Travis,Federico Canzian,Rudolph Kaaks,Fredrik Wiklund,Markus Aly,Sara Lindström,W. R. Diver,Susan M. Gapstur,Mariana C. Stern,Roman Corral,Jarmo Virtamo,Angela Cox,Christopher A. Haiman,Loic Le Marchand,Liesel M. FitzGerald,Suzanne Kolb,Erika M. Kwon,Danielle M. Karyadi,Torben F. Ørntoft,Michael Borre,Andreas Meyer,Jürgen Serth,Meredith Yeager,Sonja I. Berndt,James R. Marthick,Briony Patterson,Dominika Wokołorczyk,Jyotsna Batra,Felicity Lose,Shannon K. McDonnell,Amit Joshi,A Shahabi,Antje E. Rinckleb,A Ray,T A Sellers,Lin H-Y.,Robert A. Stephenson,J. M. Farnham,Heiko Müller,Dietrich Rothenbacher,Norihiko Tsuchiya,Shintaro Narita,Cao G-W.,C. Slavov,Vanio Mitev,Douglas F. Easton,Rosalind A. Eeles,Rosalind A. Eeles +144 more
TL;DR: The results of stage 3 are reported, in which 1,536 SNPs are evaluated in 4,574 individuals with prostate cancer (cases) and 4,164 controls and a SNP in TERT more strongly associated with PrCa than that previously reported is identified.