L
Lin H-Y.
Researcher at LSU Health Sciences Center New Orleans
Publications - 6
Citations - 491
Lin H-Y. is an academic researcher from LSU Health Sciences Center New Orleans. The author has contributed to research in topics: Genome-wide association study & Hazard ratio. The author has an hindex of 5, co-authored 6 publications receiving 460 citations. Previous affiliations of Lin H-Y. include Louisiana State University & University of South Florida.
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Journal ArticleDOI
Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study
Zsofia Kote-Jarai,Olama Aaa.,G.G. Giles,G.G. Giles,Gianluca Severi,Gianluca Severi,Johanna Schleutker,Maren Weischer,Daniele Campa,Elio Riboli,Timothy J. Key,Henrik Grönberg,David J. Hunter,Peter Kraft,Michael J. Thun,Sue A. Ingles,Stephen J. Chanock,Stephen J. Chanock,Demetrius Albanes,Richard B. Hayes,David E. Neal,David E. Neal,Freddie C. Hamdy,Jenny L Donovan,Paul D.P. Pharoah,Fredrick R. Schumacher,Brian E. Henderson,Janet L. Stanford,Janet L. Stanford,Elaine A. Ostrander,Karina Dalsgaard Sørensen,Thilo Dörk,Gerald L. Andriole,Joanne L. Dickinson,Cezary Cybulski,Jan Lubinski,Amanda B. Spurdle,Judith A. Clements,Suzanne K. Chambers,Joanne F. Aitken,Gardiner Raf.,S. N. Thibodeau,D J Schaid,Esther M. John,Esther M. John,Christiane Maier,W. Vogel,Kathleen A. Cooney,Jong Y. Park,Lisa A. Cannon-Albright,Lisa A. Cannon-Albright,Hermann Brenner,Tomonori Habuchi,Zhang H-W.,Lu Y-J.,Radka Kaneva,Kenneth Muir,Sara Benlloch,Daniel Leongamornlert,Ed Saunders,Malgorzata Tymrakiewicz,N. Mahmud,Michelle Guy,Lynne T. O'Brien,R A Wilkinson,Amanda L. Hall,E J Sawyer,Tokhir Dadaev,Jonathan J. Morrison,David P. Dearnaley,David P. Dearnaley,Alan Horwich,Alan Horwich,Robert Huddart,Robert Huddart,Vincent Khoo,Vincent Khoo,Chris Parker,Chris Parker,N. van As,C.R.J. Woodhouse,A. Thompson,Timothy J. Christmas,Chris Ogden,Colin Cooper,Aritaya Lophatonanon,Melissa C. Southey,John L. Hopper,Dallas R. English,Dallas R. English,T. Wahlfors,Tammela Tlj.,Peter Klarskov,Børge G. Nordestgaard,Martin Andreas Røder,Anne Tybjærg-Hansen,Stig E. Bojesen,Ruth C. Travis,Federico Canzian,Rudolph Kaaks,Fredrik Wiklund,Markus Aly,Sara Lindström,W. R. Diver,Susan M. Gapstur,Mariana C. Stern,Roman Corral,Jarmo Virtamo,Angela Cox,Christopher A. Haiman,Loic Le Marchand,Liesel M. FitzGerald,Suzanne Kolb,Erika M. Kwon,Danielle M. Karyadi,Torben F. Ørntoft,Michael Borre,Andreas Meyer,Jürgen Serth,Meredith Yeager,Sonja I. Berndt,James R. Marthick,Briony Patterson,Dominika Wokołorczyk,Jyotsna Batra,Felicity Lose,Shannon K. McDonnell,Amit Joshi,A Shahabi,Antje E. Rinckleb,A Ray,T A Sellers,Lin H-Y.,Robert A. Stephenson,J. M. Farnham,Heiko Müller,Dietrich Rothenbacher,Norihiko Tsuchiya,Shintaro Narita,Cao G-W.,C. Slavov,Vanio Mitev,Douglas F. Easton,Rosalind A. Eeles,Rosalind A. Eeles +144 more
TL;DR: The results of stage 3 are reported, in which 1,536 SNPs are evaluated in 4,574 individuals with prostate cancer (cases) and 4,164 controls and a SNP in TERT more strongly associated with PrCa than that previously reported is identified.
Journal ArticleDOI
A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease
Ali Amin Al Olama,Zsofia Kote-Jarai,Fredrick R. Schumacher,Fredrik Wiklund,Sonja I. Berndt,S. Benlloch,Graham G. Giles,Graham G. Giles,Gianluca Severi,Gianluca Severi,David E. Neal,David E. Neal,Freddie C. Hamdy,Jenny L Donovan,David J. Hunter,B. E. Henderson,Michael J. Thun,Michael Gaziano,Michael Gaziano,Edward Giovannucci,Afshan Siddiq,Ruth C. Travis,David G. Cox,David G. Cox,Federico Canzian,Elio Riboli,Timothy J. Key,Gerald L. Andriole,Demetrius Albanes,Richard B. Hayes,Johanna Schleutker,Johanna Schleutker,Anssi Auvinen,Tammela Tlj.,Maren Weischer,Janet L. Stanford,Janet L. Stanford,Elaine A. Ostrander,Cezary Cybulski,Jan Lubinski,S. N. Thibodeau,D J Schaid,Karina Dalsgaard Sørensen,Jyotsna Batra,Judith A. Clements,Suzanne K. Chambers,Suzanne K. Chambers,Joanne F. Aitken,Robert A. Gardiner,Christiane Maier,W. Vogel,Thilo Dörk,Hermann Brenner,Tomonori Habuchi,Sue A. Ingles,Esther M. John,Esther M. John,Joanne L. Dickinson,Lisa A. Cannon-Albright,Lisa A. Cannon-Albright,Manuel R. Teixeira,Radka Kaneva,Zhang H-W.,Lu Y-J.,Jong Y. Park,Kathleen A. Cooney,Kenneth Muir,Daniel Leongamornlert,E. Saunders,Malgorzata Tymrakiewicz,N. Mahmud,Michelle Guy,K. Govindasami,Lynne T. O'Brien,R A Wilkinson,Amanda L. Hall,E J Sawyer,Tokhir Dadaev,Jonathan J. Morrison,David P. Dearnaley,Alan Horwich,Robert Huddart,Vincent Khoo,Chris Parker,N. van As,C.R.J. Woodhouse,A. Thompson,Tim Dudderidge,Chris Ogden,Colin Cooper,Aritaya Lophatonanon,Melissa C. Southey,John L. Hopper,Dallas R. English,Dallas R. English,Jarmo Virtamo,Loic Le Marchand,D Campa,Rudolph Kaaks,S. Lindstrom,W. R. Diver,Susan M. Gapstur,Meredith Yeager,Angela Cox,Mariana C. Stern,Roman Corral,Markus Aly,W. Isaacs,Jan Adolfsson,Jianfeng Xu,Siqun L. Zheng,T. Wahlfors,Kimmo Taari,Paula Kujala,Peter Klarskov,Børge G. Nordestgaard,Martin Andreas Røder,Ruth Frikke-Schmidt,Stig E. Bojesen,Liesel M. FitzGerald,Suzanne Kolb,Erika M. Kwon,Danielle M. Karyadi,Torben F. Ørntoft,Michael Borre,Antje E. Rinckleb,Manuel Luedeke,Kathleen Herkommer,Andreas Meyer,Jürgen Serth,James R. Marthick,Briony Patterson,Dominika Wokołorczyk,Amanda B. Spurdle,Felicity Lose,Shannon K. McDonnell,Amit Joshi,Ahva Shahabi,Pedro Vaz Pinto,João Vasco Santos,Anna M. Ray,T A Sellers,Lin H-Y.,Robert A. Stephenson,Craig C. Teerlink,Heiko Müller,Dietrich Rothenbacher,Norihiko Tsuchiya,Shintaro Narita,Cao G-W.,C. Slavov,Vanio Mitev,S. J. Chanock,Henrik Grönberg,Christopher A. Haiman,Peter Kraft,Doug Easton,Rosalind A. Eeles +157 more
TL;DR: In this article, the authors conducted a meta-analysis of four GWAS including 5953 cases of aggressive prostate cancer and 11 463 controls (men without PrCa) and computed association tests for approximately 2.6 million SNPs and followed up the most significant SNPs by genotyping 49 121 samples through the international PRACTICAL and BPC3 consortia.
Journal ArticleDOI
Prediction of individual genetic risk to prostate cancer using a polygenic score.
Robert Szulkin,Tom Whitington,Martin Eklund,Markus Aly,Rosalind A. Eeles,Rosalind A. Eeles,Douglas F. Easton,Zsofia Kote-Jarai,Ali Amin Al Olama,Sara Benlloch,Kenneth Muir,Kenneth Muir,G.G. Giles,G.G. Giles,Melissa C. Southey,Liesel M. FitzGerald,B. E. Henderson,Fredrick R. Schumacher,Christopher A. Haiman,Johanna Schleutker,Johanna Schleutker,Tiina Wahlfors,Tammela Tlj.,Børge G. Nordestgaard,Børge G. Nordestgaard,Timothy J. Key,Ruth C. Travis,David E. Neal,Jenny L Donovan,Freddie C. Hamdy,Paul D.P. Pharoah,Nora Pashayan,Nora Pashayan,Khaw K-T.,Janet L. Stanford,Janet L. Stanford,S. N. Thibodeau,Shannon K. McDonnell,D J Schaid,Christiane Maier,W. Vogel,Manuel Luedeke,Kathleen Herkommer,Adam S. Kibel,Cezary Cybulski,Jan Lubinski,Wojciech Kluźniak,Lisa A. Cannon-Albright,Lisa A. Cannon-Albright,Hermann Brenner,Katja Butterbach,C. Stegmaier,Jong Y. Park,T A Sellers,Lin H-Y.,C. Slavov,Radka Kaneva,Vanio Mitev,Jyotsna Batra,Judith A. Clements,Amanda B. Spurdle,Manuel R. Teixeira,Paula Paulo,Sofia Maia,Hardev Pandha,Agnieszka Michael,Andrzej M. Kierzek,Henrik Grönberg,Fredrik Wiklund +68 more
TL;DR: Polygenic risk scores comprising established susceptibility variants have shown to be informative classifiers for several complex diseases including prostate cancer, but it is unknown if inclusion of genetic markers that have so far not been associated with prostate cancer risk at a genome‐wide significant level will improve disease prediction.
Journal ArticleDOI
The effect of sample size on polygenic hazard models for prostate cancer.
Roshan Karunamuni,Huynh-Le M-P.,Chun Chieh Fan,Rosalind A. Eeles,Douglas F. Easton,Zsofia Kote-Jarai,Ali Amin Al Olama,Sara Benlloch Garcia,Kenneth Muir,Kenneth Muir,Henrik Grönberg,Fredrik Wiklund,Markus Aly,Markus Aly,Johanna Schleutker,Johanna Schleutker,Csilla Sipeky,Tammela Tlj.,Børge G. Nordestgaard,Børge G. Nordestgaard,Timothy J. Key,Ruth C. Travis,David E. Neal,David E. Neal,Jenny L Donovan,Freddie C. Hamdy,Freddie C. Hamdy,Paul D.P. Pharoah,Nora Pashayan,Nora Pashayan,Khaw K-T.,Stephen N. Thibodeau,Shannon K. McDonnell,Daniel J. Schaid,Christiane Maier,Walther Vogel,Manuel Luedeke,Kathleen Herkommer,Adam S. Kibel,Cezary Cybulski,Dominika Wokołorczyk,Wojciech Kluzniak,Lisa A. Cannon-Albright,Lisa A. Cannon-Albright,Hermann Brenner,Ben Schöttker,Ben Schöttker,Bernd Holleczek,Jong Y. Park,Thomas A. Sellers,Lin H-Y.,C. Slavov,Radka Kaneva,Vanio Mitev,Jyotsna Batra,Jyotsna Batra,Judith A. Clements,Judith A. Clements,Amanda B. Spurdle,Manuel R. Teixeira,Paula Paulo,Sofia Maia,Hardev Pandha,Agnieszka Michael,Ian G. Mills,Ian G. Mills,Ole A. Andreassen,Anders M. Dale,Tyler M. Seibert +68 more
TL;DR: The effect of sample size on performance of polygenic hazard score (PHS) models in prostate cancer is determined and it is estimated that a study population of 20 thousand men is required to develop Discovery- SNP PHS models while 10 thousand men should be sufficient for Established-SNP models.
Journal ArticleDOI
Author Correction: Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci.
Fredrick R. Schumacher,Olama Aaa.,Sonja I. Berndt,Sara Benlloch,Munaza Ahmed,Ed Saunders,Tokhir Dadaev,D. Leongamornlert,Ezequiel Anokian,Clara Cieza-Borrella,Chee Goh,Mark N. Brook,Xin Sheng,Laura Fachal,Laura Fachal,Joe Dennis,Tyrer Jp,Kenneth Muir,Kenneth Muir,Artitaya Lophatananon,Artitaya Lophatananon,Victoria L. Stevens,Susan M. Gapstur,Brian D. Carter,Catherine M. Tangen,Phyllis J. Goodman,Ian M. Thompson,Jyotsna Batra,Suzanne K. Chambers,Leire Moya,Judith A. Clements,Lisa G. Horvath,Wayne D. Tilley,Gail P. Risbridger,Gail P. Risbridger,Henrik Grönberg,Markus Aly,Markus Aly,Tobias Nordström,P Pharoah,Nora Pashayan,Nora Pashayan,Johanna Schleutker,Johanna Schleutker,Tammela Tlj.,Csilla Sipeky,Anssi Auvinen,Demetrius Albanes,Stephanie J. Weinstein,Alicja Wolk,Alicja Wolk,Niclas Håkansson,West Cml.,Alison M. Dunning,Neil G. Burnet,Lorelei A. Mucci,Edward Giovannucci,Gerald L. Andriole,O. Cussenot,Geraldine Cancel-Tassin,Stella Koutros,L E Beane Freeman,Karina Dalsgaard Sørensen,Karina Dalsgaard Sørensen,Torben F. Ørntoft,Torben F. Ørntoft,Michael Borre,Michael Borre,Lovise Maehle,Eli Marie Grindedal,David E. Neal,David E. Neal,Jenny L Donovan,Freddie C. Hamdy,Richard M. Martin,Ruth C. Travis,Timothy J. Key,Robert J. Hamilton,Neil Fleshner,Antonio Finelli,Sue A. Ingles,Mariana C. Stern,Barry S. Rosenstein,Sarah L. Kerns,Harry Ostrer,Lu Y-J.,Zhang H-W.,Ninghan Feng,Xueying Mao,Xin Guo,Guomin Wang,Zan Sun,Graham G. Giles,Melissa C. Southey,Robert J. MacInnis,Liesel M. FitzGerald,Adam S. Kibel,Bettina F. Drake,Ana Vega,Antonio Gómez-Caamaño,Robert Szulkin,Martin Eklund,Manolis Kogevinas,Javier Llorca,Gemma Castaño-Vinyals,Kathryn L. Penney,Meir J. Stampfer,Jong Y. Park,T A Sellers,Lin H-Y.,Janet L. Stanford,Cezary Cybulski,Dominika Wokołorczyk,Jakub Lubiński,Elaine A. Ostrander,Milan S. Geybels,Børge G. Nordestgaard,Børge G. Nordestgaard,Sune F. Nielsen,Sune F. Nielsen,Maren Weischer,Rasmus Bisbjerg,Martin Andreas Røder,P Iversen,Hermann Brenner,Katarina Cuk,Bernd Holleczek,Christiane Maier,Manuel Luedeke,Thomas J. Schnoeller,Jeri Kim,Christopher J. Logothetis,Esther M. John,Manuel R. Teixeira,Paula Paulo,Marta Cardoso,Susan L. Neuhausen,Linda Steele,Yuan Chun Ding,K. De Ruyck,G De Meerleer,Piet Ost,Azad Hassan Abdul Razack,Jasmine Lim,Teo S-H.,Daniel W. Lin,Lisa F. Newcomb,Davor Lessel,Marija Gamulin,Tomislav Kuliš,Radka Kaneva,Nawaid Usmani,Sandeep Singhal,C. Slavov,Vanio Mitev,Matthew Parliament,Frank Claessens,Steven Joniau,T. Van Den Broeck,Samantha E.T. Larkin,Paul A. Townsend,Claire Aukim-Hastie,Manuela Gago-Dominguez,Jose Esteban Castelao,Maria Elena Martinez,Monique J. Roobol,G Jenster,van Schaik Rhn.,Florence Menegaux,Thérèse Truong,Yves Akoli Koudou,Jianfeng Xu,Khaw K-T.,Lisa A. Cannon-Albright,Hardev Pandha,Agnieszka Michael,Stephen N. Thibodeau,Shannon K. McDonnell,D J Schaid,Sara Lindström,Constance Turman,Jing Ma,David J. Hunter,Elio Riboli,A. Siddiq,F Canzian,Laurence N. Kolonel,Loic Le Marchand,Robert N. Hoover,Mitchell J. Machiela,Z Cui,Peter Kraft,Christopher I. Amos,David V. Conti,Douglas F. Easton,Fredrik Wiklund,Stephen J. Chanock,B. E. Henderson,Zsofia Kote-Jarai,Christopher A. Haiman,Rosalind A. Eeles,Genetic Associations,Mechanisms in Oncology +202 more
TL;DR: In the version of this article initially published, the name of author Manuela Gago-Dominguez was misspelled as ManuelA Gago Dominguez, but the error has been corrected.