F
Fred H. Menko
Researcher at Netherlands Cancer Institute
Publications - 167
Citations - 15540
Fred H. Menko is an academic researcher from Netherlands Cancer Institute. The author has contributed to research in topics: Cancer & Germline mutation. The author has an hindex of 57, co-authored 163 publications receiving 14553 citations. Previous affiliations of Fred H. Menko include VU University Medical Center & VU University Amsterdam.
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Journal ArticleDOI
Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13
Richard Wooster,Susan L. Neuhausen,Jonathan Mangion,Yvette Quirk,D Ford,N. Collins,K. Nguyen,Sheila Seal,T.D. Tran,D. Averill,P Fields,Gill Marshall,Steven A. Narod,Gilbert M. Lenoir,Henry T. Lynch,Jean Feunteun,Peter Devilee,Cees J. Cornelisse,Fred H. Menko,Peter A. Daly,Wilma Ormiston,Ross McManus,Carole Pye,Cathryn M. Lewis,Lisa A. Cannon-Albright,Julian Peto,Bruce A.J. Ponder,Mark H. Skolnick,Douglas F. Easton,David E. Goldgar,Michael R. Stratton +30 more
TL;DR: This analysis localized a second breast cancer susceptibility locus, BRCA2, to a 6-centimorgan interval on chromosome 13q12-13, which preliminary evidence suggests suggests confers a high risk of breast cancer but does not confer a substantially elevated risk of ovarian cancer.
Journal ArticleDOI
Cancer risk in families with hereditary nonpolyposis colorectal cancer diagnosed by mutation analysis.
Hans F. A. Vasen,J. T. Wijnen,Fred H. Menko,Jan H. Kleibeuker,B. G. Taal,Gerrit Griffioen,Fokko M. Nagengast,E. H. Meijers-Heijboer,Lucio Bertario,L. Varesco,Marie Luise Bisgaard,J. Mohr,Riccardo Fodde,P M Khan +13 more
TL;DR: Estimates of cancer risk that may contribute to the appropriate management of gene carriers within families with hereditary nonpolyposis colorectal cancer are provided.
Journal ArticleDOI
Frequency and Spectrum of Cancers in the Peutz-Jeghers Syndrome
N Hearle,Valérie Schumacher,Fred H. Menko,Sylviane Olschwang,Lisa A. Boardman,Johan J.P. Gille,J J Keller,Anne Marie Westerman,Rodney J. Scott,Wendy Lim,Jill D. Trimbath,Francis M. Giardiello,Stephen B. Gruber,G. Johan A. Offerhaus,Felix W. M. de Rooij,J. H. Paul Wilson,Anika Hansmann,Gabriela Möslein,Brigitte Royer-Pokora,Tilman Vogel,Robin K. S. Phillips,Allan D. Spigelman,Richard S. Houlston +22 more
TL;DR: Cancer risks were similar in Peutz-Jeghers syndrome patients with identified STK11/LKB1 mutations and those with no detectable mutation (log-rank test of difference χ2; 1 df; P = 0.43), and the type or site of STK 11/L KB1 mutation did not significantly influence cancer risk.
Journal ArticleDOI
Dysplastic changes in prophylactically removed Fallopian tubes of women predisposed to developing ovarian cancer
Jurgen M.J. Piek,P. J. Van Diest,Ronald P. Zweemer,J W Jansen,Ria J.J. Poort-Keesom,Fred H. Menko,Johan J.P. Gille,A P M Jongsma,Gerard Pals,Peter Kenemans,R Verheijen +10 more
TL;DR: The Fallopian tubes of women predisposed to developing ovarian cancer frequently harbour dysplastic changes, accompanied by changes in cell‐cycle and apoptosis‐related proteins, indicating an increased risk of developing tubal cancer.
Journal ArticleDOI
Familial endometrial cancer in female carriers of MSH6 germline mutations
Juul T. Wijnen,W. J. F. De Leeuw,Hans F. A. Vasen,H. van der Klift,Pål Møller,Astrid Stormorken,Hanne Meijers-Heijboer,Dick Lindhout,Fred H. Menko,S Vossen,G Moslein,Carli M. J. Tops,A Brocker-Vriends,Ying Wu,Robert M. W. Hofstra,Rolf H. Sijmons,Cees J. Cornelisse,Hans Morreau,Riccardo Fodde +18 more
TL;DR: Hereditary non-polyposis colorectal cancer was shown to be caused by germline mutations in the DNA mismatch repair genes MSH2, MLH1, PMS1,PMS2 and MSH6, and many HNPCC families do not fully comply with the clinical Amsterdam criteria, and the causative mutations are unknown.