M
Miriam F. Moffatt
Researcher at National Institutes of Health
Publications - 19
Citations - 7794
Miriam F. Moffatt is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Genome-wide association study & Gene expression profiling. The author has an hindex of 17, co-authored 19 publications receiving 7001 citations. Previous affiliations of Miriam F. Moffatt include Imperial College London.
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Journal ArticleDOI
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
Elizabeth K. Speliotes,Elizabeth K. Speliotes,Cristen J. Willer,Sonja I. Berndt,Keri L. Monda,Gudmar Thorleifsson,Anne U. Jackson,Hana Lango Allen,Cecilia M. Lindgren,Jian'an Luan,Reedik Maegi,Joshua C. Randall,Sailaja Vedantam,Thomas W. Winkler,Lu Qi,Lu Qi,Tsegaselassie Workalemahu,Iris M. Heid,Valgerdur Steinthorsdottir,Heather M. Stringham,Michael N. Weedon,Eleanor Wheeler,Andrew R. Wood,Teresa Ferreira,Robert J. Weyant,Ayellet V. Segrè,Ayellet V. Segrè,Karol Estrada,Liming Liang,James Nemesh,James Nemesh,Ju-Hyun Park,Stefan Gustafsson,Tuomas O. Kilpelaenen,Jian Yang,Nabila Bouatia-Naji,Nabila Bouatia-Naji,Tõnu Esko,Mary F. Feitosa,Zoltán Kutalik,Massimo Mangino,Soumya Raychaudhuri,Soumya Raychaudhuri,Soumya Raychaudhuri,André Scherag,Albert V. Smith,Ryan P. Welch,Jing Hua Zhao,Katja K.H. Aben,Devin Absher,Najaf Amin,Anna L. Dixon,Eva Fisher,Nicole L. Glazer,Michael E. Goddard,Nancy L. Heard-Costa,Volker Hoesel,Jouke-Jan Hottenga,Åsa Johansson,Åsa Johansson,Toby Johnson,Shamika Ketkar,Claudia Lamina,Shengxu Li,Miriam F. Moffatt,Richard H. Myers,Narisu Narisu,John R. B. Perry,Marjolein Peters,Michael Preuss,Samuli Ripatti,Fernando Rivadeneira,Camilla H. Sandholt,Laura J. Scott,Nicholas J. Timpson,Jonathan Tyrer,Sophie van Wingerden,Richard M. Watanabe,Charles C. White,Fredrik Wiklund,Christina Barlassina,Daniel I. Chasman,Daniel I. Chasman,Mark E. Cooper,John-Olov Jansson,Robert Lawrence,Niina Pellikka,Inga Prokopenko,Jianxin Shi,Elisabeth Thiering,Helene Alavere,Maria Teresa Sciarrone Alibrandi,Peter Almgren,Alice M. Arnold,Thor Aspelund,Larry D. Atwood,Beverley Balkau,Anthony J. Balmforth,Amanda J. Bennett,Yoav Ben-Shlomo,Richard N. Bergman,Sven Bergmann,Heike Biebermann,Alexandra I. F. Blakemore,Tanja Boes,Lori L. Bonnycastle,Stefan R. Bornstein,Morris Brown,Thomas A. Buchanan,Fabio Busonero,Harry Campbell,Francesco P. Cappuccio,Christine Cavalcanti-Proença,Christine Cavalcanti-Proença,Yii-Der Ida Chen,Chih-Mei Chen,Peter S. Chines,Robert Clarke,Lachlan J. M. Coin,John M. C. Connell,Ian N. M. Day,Martin den Heijer,Jubao Duan,Shah Ebrahim,Paul Elliott,Roberto Elosua,Gudny Eiriksdottir,Michael R. Erdos,Johan G. Eriksson,Maurizio F. Facheris,Stephan B. Felix,Pamela Fischer-Posovszky,Aaron R. Folsom,Aaron R. Folsom,Nele Friedrich,Nelson B. Freimer,Mao Fu,Stefan Gaget,Stefan Gaget,Pablo V. Gejman,Eco J. C. de Geus,Christian Gieger,Anette P. Gjesing,Anuj Goel,Philippe Goyette,Harald Grallert,Juergen Graessler,Danielle M. Greenawalt,Christopher J. Groves,Vilmundur Gudnason,Candace Guiducci,Anna-Liisa Hartikainen,Neelam Hassanali,Alistair S. Hall,Aki S. Havulinna,Caroline Hayward,Andrew C. Heath,Christian Hengstenberg,Andrew A. Hicks,Anke Hinney,Albert Hofman,Georg Homuth,Jennie Hui,Wilmar Igl,Carlos Iribarren,Carlos Iribarren,Bo Isomaa,Kevin B. Jacobs,Ivonne Jarick,Elizabeth S. Jewell,Ulrich John,Torben Jørgensen,Pekka Jousilahti,Antti Jula,Marika Kaakinen,Eero Kajantie,Lee M. Kaplan,Sekar Kathiresan,Johannes Kettunen,Leena Kinnunen,Joshua W. Knowles,Ivana Kolcic,Inke R. Koenig,Seppo Koskinen,Peter Kovacs,Johanna Kuusisto,Peter Kraft,Kirsti Kvaløy,Jaana Laitinen,Olivier Lantieri,Chiara Lanzani,Lenore J. Launer,Cécile Lecoeur,Cécile Lecoeur,Terho Lehtimaeki,Guillaume Lettre,Guillaume Lettre,Jianjun Liu,Marja-Liisa Lokki,Mattias Lorentzon,Robert Luben,Barbara Ludwig,Paolo Manunta,Diana Marek,Michel Marre,Nicholas G. Martin,Wendy L. McArdle,Anne McCarthy,Barbara McKnight,Thomas Meitinger,Olle Melander,David Meyre,David Meyre,Kristian Midthjell,Grant W. Montgomery,Mario A. Morken,Andrew P. Morris,Rosanda Mulić,Julius S. Ngwa,Mari Nelis,Mari Nelis,Matt Neville,Dale R. Nyholt,Christopher J. O'Donnell,Stephen O'Rahilly,Ken K. Ong,Ben A. Oostra,Guillaume Paré,Alex N. Parker,Markus Perola,Irene Pichler,Kirsi H. Pietilaeinen,Carl G. P. Platou,Ozren Polasek,Anneli Pouta,Suzanne Rafelt,Olli T. Raitakari,Nigel W. Rayner,Martin Ridderstråle,Winfried Rief,Aimo Ruokonen,Neil Robertson,Peter Rzehak,Veikko Salomaa,Alan R. Sanders,Manjinder S. Sandhu,Manjinder S. Sandhu,Serena Sanna,Jouko Saramies,Markku J. Savolainen,Susann Scherag,Sabine Schipf,Stefan Schreiber,Heribert Schunkert,Kaisa Silander,Juha Sinisalo,David S. Siscovick,Jan Smit,Nicole Soranzo,Nicole Soranzo,Ulla Sovio,Jonathan Stephens,Jonathan Stephens,Ida Surakka,Amy J. Swift,Mari-Liis Tammesoo,Jean-Claude Tardif,Jean-Claude Tardif,Maris Teder-Laving,Tanya M. Teslovich,John R. Thompson,John R. Thompson,Brian Thomson,Anke Toenjes,Tiinamaija Tuomi,Joyce B. J. van Meurs,Gert-Jan B. van Ommen,Vincent Vatin,Vincent Vatin,Jorma S. A. Viikari,Jorma S. A. Viikari,Sophie Visvikis-Siest,Veronique Vitart,Carla I. G. Vogel,Benjamin F. Voight,Lindsay L. Waite,Henri Wallaschofski,G. Bragi Walters,Elisabeth Widen,Susanna Wiegand,Sarah H. Wild,Gonneke Willemsen,Daniel R. Witte,Jacqueline C. M. Witteman,Jianfeng Xu,Qunyuan Zhang,Lina Zgaga,Andreas Ziegler,Paavo Zitting,John Beilby,I. Sadaf Farooqi,Johannes Hebebrand,Heikki V. Huikuri,Alan James,Mika Kaehoenen,Douglas F. Levinson,Fabio Macciardi,Fabio Macciardi,Markku S. Nieminen,Claes Ohlsson,Lyle J. Palmer,Paul M. Ridker,Paul M. Ridker,Michael Stumvoll,Jacques S. Beckmann,Heiner Boeing,Eric Boerwinkle,Dorret I. Boomsma,Mark J. Caulfield,Stephen J. Chanock,Francis S. Collins,L. Adrienne Cupples,George Davey Smith,Jeanette Erdmann,Philippe Froguel,Philippe Froguel,Philippe Froguel,Henrik Greonberg,Ulf Gyllensten,Per Hall,Torben Hansen,Tamara B. Harris,Andrew T. Hattersley,Richard B. Hayes,Joachim Heinrich,Frank B. Hu,Frank B. Hu,Kristian Hveem,Thomas Illig,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Jaakko Kaprio,Fredrik Karpe,Kay-Tee Khaw,Lambertus A. Kiemeney,Heiko Krude,Markku Laakso,Debbie A Lawlor,Andres Metspalu,Patricia B. Munroe,Willem H. Ouwehand,Willem H. Ouwehand,Willem H. Ouwehand,Oluf Pedersen,Oluf Pedersen,Brenda W.J.H. Penninx,Brenda W.J.H. Penninx,Annette Peters,Peter P. Pramstaller,Thomas Quertermous,Thomas Reinehr,Aila Rissanen,Igor Rudan,Igor Rudan,Nilesh J. Samani,Peter Schwarz,Alan R. Shuldiner,Tim D. Spector,Jaakko Tuomilehto,Manuela Uda,André G. Uitterlinden,Timo T. Valle,Martin Wabitsch,Gerard Waeber,Nicholas J. Wareham,Hugh Watkins,James F. Wilson,Alan F. Wright,M. Carola Zillikens,Nilanjan Chatterjee,Steven A. McCarroll,Shaun Purcell,Eric E. Schadt,Peter M. Visscher,Themistocles L. Assimes,Ingrid B. Borecki,Panos Deloukas,Caroline S. Fox,Leif Groop,Talin Haritunians,David J. Hunter,David J. Hunter,Robert C. Kaplan,Karen L. Mohlke,Jeffrey R. O'Connell,Leena Peltonen,David Schlessinger,David P. Strachan,Cornelia M. van Duijn,H-Erich Wichmann,Timothy M. Frayling,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Gonçalo R. Abecasis,Inês Barroso,Inês Barroso,Michael Boehnke,Kari Stefansson,Kari Stefansson,Kari E. North,Mark I. McCarthy,Joel N. Hirschhorn,Erik Ingelsson,Ruth J. F. Loos +413 more
TL;DR: Genetic loci associated with body mass index map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor, which may provide new insights into human body weight regulation.
Journal ArticleDOI
Reagent and laboratory contamination can critically impact sequence-based microbiome analyses
Susannah J. Salter,Michael J. Cox,Elena M. Turek,Szymon T. Calus,William O.C.M. Cookson,Miriam F. Moffatt,Paul Turner,Paul Turner,Julian Parkhill,Nicholas J. Loman,Alan W. Walker,Alan W. Walker +11 more
TL;DR: It is demonstrated that contaminating DNA is ubiquitous in commonly used DNA extraction kits and other laboratory reagents, varies greatly in composition between different kits and kit batches, and that this contamination critically impacts results obtained from samples containing a low microbial biomass.
Journal ArticleDOI
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
Sonja I. Berndt,Stefan Gustafsson,Stefan Gustafsson,Reedik Mägi,Reedik Mägi,Andrea Ganna,Eleanor Wheeler,Mary F. Feitosa,Anne E. Justice,Keri L. Monda,Keri L. Monda,Damien C. Croteau-Chonka,Felix R. Day,Tõnu Esko,Tove Fall,Teresa Ferreira,Davide Gentilini,Anne U. Jackson,Jian'an Luan,Joshua C. Randall,Joshua C. Randall,Sailaja Vedantam,Sailaja Vedantam,Sailaja Vedantam,Cristen J. Willer,Thomas W. Winkler,Andrew R. Wood,Tsegaselassie Workalemahu,Tsegaselassie Workalemahu,Yi-Juan Hu,Sang Hong Lee,Liming Liang,Danyu Lin,Josine L. Min,Benjamin M. Neale,Gudmar Thorleifsson,Jian Yang,Jian Yang,Eva Albrecht,Najaf Amin,Jennifer L. Bragg-Gresham,Gemma Cadby,Gemma Cadby,Martin den Heijer,Niina Eklund,Krista Fischer,Anuj Goel,Jouke-Jan Hottenga,Jennifer E. Huffman,Ivonne Jarick,Åsa Johansson,Åsa Johansson,Toby Johnson,Stavroula Kanoni,Marcus E. Kleber,Inke R. König,Kati Kristiansson,Zoltán Kutalik,Zoltán Kutalik,Claudia Lamina,Cécile Lecoeur,Cécile Lecoeur,Guo Li,Massimo Mangino,Wendy L. McArdle,Carolina Medina-Gomez,Martina Müller-Nurasyid,Julius S. Ngwa,Ilja M. Nolte,Lavinia Paternoster,Sonali Pechlivanis,Markus Perola,Markus Perola,Markus Perola,Marjolein J. Peters,Michael Preuss,Lynda M. Rose,Jianxin Shi,Dmitry Shungin,Dmitry Shungin,Albert V. Smith,Rona J. Strawbridge,Ida Surakka,Ida Surakka,Alexander Teumer,Mieke D. Trip,Jonathan Tyrer,Jana V. van Vliet-Ostaptchouk,Liesbeth Vandenput,Lindsay L. Waite,Jing Hua Zhao,Devin Absher,Folkert W. Asselbergs,Mustafa Atalay,Antony P. Attwood,Anthony J. Balmforth,Hanneke Basart,John Beilby,Lori L. Bonnycastle,Paolo Brambilla,Marcel Bruinenberg,Harry Campbell,Daniel I. Chasman,Daniel I. Chasman,Peter S. Chines,Francis S. Collins,John M. C. Connell,John M. C. Connell,William O.C.M. Cookson,Ulf de Faire,Femmie de Vegt,Mariano Dei,Maria Dimitriou,Sarah Edkins,Karol Estrada,David M. Evans,Martin Farrall,Marco M Ferrario,Jean Ferrières,Lude Franke,Francesca Frau,Pablo V. Gejman,Pablo V. Gejman,Harald Grallert,Henrik Grönberg,Vilmundur Gudnason,Alistair S. Hall,Per Hall,Anna-Liisa Hartikainen,Caroline Hayward,Nancy L. Heard-Costa,Andrew C. Heath,Johannes Hebebrand,Georg Homuth,Frank B. Hu,Sarah E. Hunt,Elina Hyppönen,Carlos Iribarren,Kevin B. Jacobs,Kevin B. Jacobs,John-Olov Jansson,Antti Jula,Mika Kähönen,Sekar Kathiresan,Frank Kee,Kay-Tee Khaw,Mika Kivimäki,Wolfgang Koenig,Aldi T. Kraja,Meena Kumari,Kari Kuulasmaa,Johanna Kuusisto,Jaana Laitinen,Timo A. Lakka,Claudia Langenberg,Claudia Langenberg,Lenore J. Launer,Lars Lind,Jaana Lindström,Jianjun Liu,Antonio Liuzzi,Marja-Liisa Lokki,Mattias Lorentzon,Pamela A. F. Madden,Patrik K. E. Magnusson,Paolo Manunta,Diana Marek,Diana Marek,Winfried März,Winfried März,Irene Mateo Leach,Barbara McKnight,Sarah E. Medland,Evelin Mihailov,Lili Milani,Grant W. Montgomery,Vincent Mooser,Thomas W. Mühleisen,Patricia B. Munroe,Arthur W. Musk,Arthur W. Musk,Narisu Narisu,Gerjan Navis,George Nicholson,Ellen A. Nohr,Ken K. Ong,Ben A. Oostra,Ben A. Oostra,Colin N. A. Palmer,Aarno Palotie,Aarno Palotie,John F. Peden,Nancy L. Pedersen,Annette Peters,Ozren Polasek,Anneli Pouta,Anneli Pouta,Peter P. Pramstaller,Inga Prokopenko,Inga Prokopenko,Carolin Pütter,Aparna Radhakrishnan,Aparna Radhakrishnan,Aparna Radhakrishnan,Olli T. Raitakari,Olli T. Raitakari,Augusto Rendon,Fernando Rivadeneira,Igor Rudan,Timo Saaristo,Jennifer G. Sambrook,Jennifer G. Sambrook,Alan R. Sanders,Alan R. Sanders,Serena Sanna,Jouko Saramies,Sabine Schipf,Stefan Schreiber,Heribert Schunkert,So-Youn Shin,Stefano Signorini,Juha Sinisalo,Boris Skrobek,Boris Skrobek,Nicole Soranzo,Nicole Soranzo,Alena Stančáková,Klaus Stark,Jonathan Stephens,Jonathan Stephens,Kathleen Stirrups,Ronald P. Stolk,Michael Stumvoll,Amy J. Swift,Eirini V. Theodoraki,Barbara Thorand,David-Alexandre Trégouët,Elena Tremoli,Melanie M. van der Klauw,Joyce B. J. van Meurs,Sita H. Vermeulen,Jorma Viikari,Jarmo Virtamo,Veronique Vitart,Gérard Waeber,Zhaoming Wang,Zhaoming Wang,Elisabeth Widen,Sarah H. Wild,Gonneke Willemsen,Bernhard R. Winkelmann,Jacqueline C.M. Witteman,Bruce H. R. Wolffenbuttel,Andrew Wong,Alan F. Wright,M. Carola Zillikens,Philippe Amouyel,Bernhard O. Boehm,Eric Boerwinkle,Dorret I. Boomsma,Mark J. Caulfield,Stephen J. Chanock,L. Adrienne Cupples,Daniele Cusi,George Dedoussis,Jeanette Erdmann,Jeanette Erdmann,Johan G. Eriksson,Johan G. Eriksson,Johan G. Eriksson,Paul W. Franks,Paul W. Franks,Paul W. Franks,Philippe Froguel,Philippe Froguel,Philippe Froguel,Christian Gieger,Ulf Gyllensten,Anders Hamsten,Tamara B. Harris,Christian Hengstenberg,Andrew A. Hicks,Aroon D. Hingorani,Anke Hinney,Albert Hofman,Kees Hovingh,Kristian Hveem,Thomas Illig,Marjo-Riitta Järvelin,Karl-Heinz Jöckel,Sirkka Keinänen-Kiukaanniemi,Sirkka Keinänen-Kiukaanniemi,Lambertus A. Kiemeney,Diana Kuh,Markku Laakso,Terho Lehtimäki,Douglas F. Levinson,Nicholas G. Martin,Andres Metspalu,Andrew D. Morris,Markku S. Nieminen,Inger Njølstad,Claes Ohlsson,Albertine J. Oldehinkel,Willem H. Ouwehand,Lyle J. Palmer,Brenda W.J.H. Penninx,Chris Power,Michael A. Province,Bruce M. Psaty,Lu Qi,Lu Qi,Rainer Rauramaa,Paul M. Ridker,Paul M. Ridker,Samuli Ripatti,Samuli Ripatti,Samuli Ripatti,Veikko Salomaa,Nilesh J. Samani,Nilesh J. Samani,Harold Snieder,Thorkild I. A. Sørensen,Tim D. Spector,Kari Stefansson,Kari Stefansson,Anke Tönjes,Jaakko Tuomilehto,Jaakko Tuomilehto,Jaakko Tuomilehto,André G. Uitterlinden,Matti Uusitupa,Pim van der Harst,Peter Vollenweider,Henri Wallaschofski,Nicholas J. Wareham,Hugh Watkins,H-Erich Wichmann,James F. Wilson,Gonçalo R. Abecasis,Themistocles L. Assimes,Inês Barroso,Inês Barroso,Michael Boehnke,Ingrid B. Borecki,Panos Deloukas,Caroline S. Fox,Timothy M. Frayling,Leif Groop,Talin Haritunian,Iris M. Heid,David J. Hunter,David J. Hunter,Robert C. Kaplan,Fredrik Karpe,Fredrik Karpe,Miriam F. Moffatt,Karen L. Mohlke,Jeffrey R. O'Connell,Yudi Pawitan,Eric E. Schadt,David Schlessinger,Valgerdur Steinthorsdottir,David P. Strachan,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Cornelia M. van Duijn,Cornelia M. van Duijn,Peter M. Visscher,Anna Maria Di Blasio,Joel N. Hirschhorn,Joel N. Hirschhorn,Joel N. Hirschhorn,Cecilia M. Lindgren,Andrew P. Morris,David Meyre,David Meyre,David Meyre,André Scherag,Mark I. McCarthy,Mark I. McCarthy,Mark I. McCarthy,Elizabeth K. Speliotes,Kari E. North,Ruth J. F. Loos,Erik Ingelsson +385 more
TL;DR: A genome-wide search for loci associated with the upper versus the lower 5th percentiles of body mass index, height and waist-to-hip ratio as well as clinical classes of obesity, including up to 263,407 individuals of European ancestry finds a large overlap in genetic structure and the distribution of variants between traits based on extremes and the general population and little etiological heterogeneity between obesity subgroups.
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
Sonja I. Berndt,Stefan Gustafsson,Reedik Maegi,Andrea Ganna,Eleanor Wheeler,Mary F. Feitosa,Anne E. Justice,Keri L. Monda,Damien C. Croteau-Chonka,Felix R. Day,Tõnu Esko,Tove Fall,Teresa Ferreira,Davide Gentilini,Anne U. Jackson,Jian'an Luan,Joshua C. Randall,Sailaja Vedantam,Cristen J. Willer,Thomas W. Winkler,Andrew R. Wood,Tsegaselassie Workalemahu,Yi-Juan Hu,Sang Hong Lee,Liming Liang,Danyu Lin,Josine L. Min,Benjamin M. Neale,Gudmar Thorleifsson,Jian Yang,Eva Albrecht,Najaf Amin,Jennifer L. Bragg-Gresham,Gemma Cadby,Martin den Heijer,Niina Eklund,Krista Fischer,Anuj Goel,Jouke-Jan Hottenga,Jennifer E. Huffman,Ivonne Jarick,Åsa Johansson,Toby Johnson,Stavroula Kanoni,Marcus E. Kleber,Inke R. Koenig,Kati Kristiansson,Z. Kutalik,Claudia Lamina,Cécile Lecoeur,Guo Li,Massimo Mangino,Wendy L. McArdle,Carolina Medina-Gomez,Martina Mueller-Nurasyid,Julius S. Ngwa,Ilja M. Nolte,Lavinia Paternoster,Sonali Pechlivanis,Markus Perola,Marjolein Peters,Michael Preuss,Lynda M. Rose,Jianxin Shi,Dmitry Shungin,Albert V. Smith,Rona J. Strawbridge,Ida Surakka,Alexander Teumer,Mieke D. Trip,Jonathan Tyrer,Jana V. van Vliet-Ostaptchouk,Liesbeth Vandenput,Lindsay L. Waite,Jing Hua Zhao,Devin Absher,Folkert W. Asselbergs,Mustafa Atalay,Antony P. Attwood,Anthony J. Balmforth,Hanneke Basart,John Beilby,Lori L. Bonnycastle,Paolo Brambilla,Marcel Bruinenberg,Harry Campbell,Daniel I. Chasman,Peter S. Chines,Francis S. Collins,John M. C. Connell,William O.C.M. Cookson,Ulf de Faire,Femmie de Vegt,Mariano Dei,Maria Dimitriou,Sarah Edkins,Karol Estrada,David M. Evans,Martin Farrall,Marco M Ferrario,Jean Ferrières,Lude Franke,Francesca Frau,Pablo V. Gejman,Harald Grallert,Henrik Groenberg,Vilmundur Gudnason,Alistair S. Hall,Per Hall,Anna-Liisa Hartikainen,Caroline Hayward,Nancy L. Heard-Costa,Andrew Heath,Johannes Hebebrand,Georg Homuth,Frank B. Hu,Sarah E. Hunt,Elina Hyppoenen,Carlos Iribarren,Kevin B. Jacobs,John-Olov Jansson,Antti Jula,Mika Kähönen,Sekar Kathiresan,Frank Kee,Kay-Tee Khaw,Mika Kivimäki,Wolfgang Koenig,Aldi T. Kraja,Meena Kumari,Kari Kuulasmaa,Johanna Kuusisto,Jaana Laitinen,Timo A. Lakka,Claudia Langenberg,Lenore J. Launer,Lars Lind,Jaana Lindström,Jianjun Liu,Antonio Liuzzi,Marja-Liisa Lokki,Mattias Lorentzon,Pamela A. F. Madden,Patrik K. E. Magnusson,Paolo Manunta,Diana Marek,Winfried Maerz,Irene Mateo Leach,Barbara McKnight,Sarah E. Medland,Evelin Mihailov,Lili Milani,Grant W. Montgomery,Vincent Mooser,Thomas W. Muehleisen,Patricia B. Munroe,Arthur W. Musk,Narisu Narisu,Gerjan Navis,George Nicholson,Ellen A. Nohr,Ken K. Ong,Ben A. Oostra,Colin N. A. Palmer,Aarno Palotie,John F. Peden,Nancy L. Pedersen,Annette Peters,Ozren Polasek,Anneli Pouta,Peter P. Pramstaller,Inga Prokopenko,Carolin Puetter,Aparna Radhakrishnan,Olli T. Raitakari,Augusto Rendon,Fernando Rivadeneira,Igor Rudan,Timo Saaristo,Jennifer G. Sambrook,Alan R. Sanders,Serena Sanna,Jouko Saramies,Sabine Schipf,Stefan Schreiber,Heribert Schunkert,So-Youn Shin,Stefano Signorini,Juha Sinisalo,Boris Skrobek,Nicole Soranzo,Alena Stančáková,Klaus Stark,Jonathan Stephens,Kathleen Stirrups,Ronald P. Stolk,Michael Stumvoll,Amy J. Swift,Eirini V. Theodoraki,Barbara Thorand,David-Alexandre Trégouët,Elena Tremoli,Melanie M. van der Klauw,Joyce B. J. van Meurs,Sita H. Vermeulen,Jorma Viikari,Jarmo Virtamo,Veronique Vitart,Gérard Waeber,Zhaoming Wang,Elisabeth Widen,Sarah H. Wild,Gonneke Willemsen,Bernhard R. Winkelmann,Jacqueline C.M. Witteman,Bruce H. R. Wolffenbuttel,Andrew Wong,Alan F. Wright,M. Carola Zillikens,Philippe Amouyel,Bernhard O. Boehm,Eric Boerwinkle,Dorret I. Boomsma,Mark J. Caulfield,Stephen J. Chanock,L. Adrienne Cupples,Daniele Cusi,George Dedoussis,Jeanette Erdmann,Johan G. Eriksson,Paul W. Franks,Philippe Froguel,Christian Gieger,Ulf Gyllensten,Anders Hamsten,Tamara B. Harris,Christian Hengstenberg,Andrew A. Hicks,Aroon D. Hingorani,Anke Hinney,Albert Hofman,Kees Hovingh,Kristian Hveem,Thomas Illig,Marjo-Riitta Järvelin,Karl-Heinz Joeckel,Sirkka Keinänen-Kiukaanniemi,Lambertus A. Kiemeney,Diana Kuh,Markku Laakso,Terho Lehtimäki,Douglas F. Levinson,Nicholas G. Martin,Andres Metspalu,Andrew D. Morris,Markku S. Nieminen,Inger Njølstad,Claes Ohlsson,Albertine J. Oldehinkel,Willem H. Ouwehand,Lyle J. Palmer,Brenda W.J.H. Penninx,Chris Power,Michael A. Province,Bruce M. Psaty,Lu Qi,Rainer Rauramaa,Paul M. Ridker,Samuli Ripatti,Veikko Salomaa,Nilesh J. Samani,Harold Snieder,Thorkild I. A. Sørensen,Tim D. Spector,Kari Stefansson,Anke Tönjes,Jaakko Tuomilehto,André G. Uitterlinden,Matti Uusitupa,Pim van der Harst,Peter Vollenweider,Henri Wallaschofski,Nicholas J. Wareham,Hugh Watkins,H-Erich Wichmann,James F. Wilson,Gonçalo R. Abecasis,Themistocles L. Assimes,Inês Barroso,Michael Boehnke,Ingrid B. Borecki,Panos Deloukas,Caroline S. Fox,Timothy M. Frayling,Leif Groop,Talin Haritunian,Iris M. Heid,David J. Hunter,Robert C. Kaplan,Fredrik Karpe,Miriam F. Moffatt,Karen L. Mohlke,Jeffrey R. O'Connell,Yudi Pawitan,Eric E. Schadt,David Schlessinger,Valgerdur Steinthorsdottir,David P. Strachan,Unnur Thorsteinsdottir,Cornelia M. van Duijn,Peter M. Visscher,Anna Maria Di Blasio,Joel N. Hirschhorn,Cecilia M. Lindgren,Andrew P. Morris,David Meyre,Andr Scherag,Mark I. McCarthy,Elizabeth K. Speliotes,Kari E. North,Ruth J. F. Loos,Erik Ingelsson +321 more
Journal ArticleDOI
Seventy-five genetic loci influencing the human red blood cell
Pim van der Harst,Weihua Zhang,Irene Mateo Leach,Augusto Rendon,Niek Verweij,Joban Sehmi,Dirk S. Paul,Ulrich Elling,Hooman Allayee,Xinzhong Li,Aparna Radhakrishnan,Sian Tsung Tan,Katrin Voss,Christian X. Weichenberger,Cornelis A. Albers,Abtehale Al-Hussani,Folkert W. Asselbergs,Marina Ciullo,Fabrice Danjou,Christian Dina,Tõnu Esko,David M. Evans,Lude Franke,Martin Gögele,Jaana Hartiala,Micha Hersch,Hilma Holm,Jouke-Jan Hottenga,Stavroula Kanoni,Marcus E. Kleber,Vasiliki Lagou,Claudia Langenberg,Lorna M. Lopez,Leo-Pekka Lyytikäinen,Olle Melander,Federico Murgia,Ilja M. Nolte,Paul F. O'Reilly,Sandosh Padmanabhan,Afshin Parsa,Nicola Pirastu,Eleonora Porcu,Laura Portas,Inga Prokopenko,Janina S. Ried,So-Youn Shin,Clara S. Tang,Alexander Teumer,Michela Traglia,Sheila Ulivi,Harm-Jan Westra,Jian Yang,Jing Hua Zhao,Franco Anni,Abdel Abdellaoui,Antony P. Attwood,Beverley Balkau,Stefania Bandinelli,François Bastardot,Beben Benyamin,Bernhard O. Boehm,William O.C.M. Cookson,Debashish Das,Paul I.W. de Bakker,Rudolf A. de Boer,Eco J. C. de Geus,Marleen H. M. de Moor,Maria Dimitriou,Francisco S. Domingues,Angela Döring,Gunnar Engström,Gudmundur I. Eyjolfsson,Luigi Ferrucci,Krista Fischer,Renzo Galanello,Stephen F. Garner,Bernd Genser,Quince Gibson,Giorgia Girotto,Daniel F. Gudbjartsson,Sarah E. Harris,Anna-Liisa Hartikainen,Claire E. Hastie,Bo Hedblad,Thomas Illig,Jennifer Jolley,Mika Kähönen,Ido P. Kema,John P. Kemp,Liming Liang,Heather Lloyd-Jones,Ruth J. F. Loos,Stuart Meacham,Sarah E. Medland,Christa Meisinger,Yasin Memari,Evelin Mihailov,Kathy Miller,Miriam F. Moffatt,Matthias Nauck,Maria Novatchkova,Teresa Nutile,Isleifur Olafsson,Pall T. Onundarson,Debora Parracciani,Brenda W.J.H. Penninx,Lucia Perseu,Antonio Piga,Giorgio Pistis,Anneli Pouta,Ursula Puc,Olli T. Raitakari,Susan M. Ring,Antonietta Robino,Daniela Ruggiero,Aimo Ruokonen,Aude Saint-Pierre,Cinzia Sala,Andres Salumets,Jennifer G. Sambrook,Hein Schepers,Carsten Oliver Schmidt,Herman H W Silljé,Robert Sladek,Johannes H. Smit,John M. Starr,Jonathan Stephens,Patrick Sulem,Toshiko Tanaka,Unnur Thorsteinsdottir,Vinicius Tragante,Wiek H. van Gilst,L. Joost van Pelt,Dirk J. van Veldhuisen,Uwe Völker,John Whitfield,Gonneke Willemsen,Bernhard R. Winkelmann,Gerald Wirnsberger,Ale Algra,Francesco Cucca,Adamo Pio D'Adamo,John Danesh,Ian J. Deary,Anna F. Dominiczak,Paul Elliott,Paolo Fortina,Philippe Froguel,Paolo Gasparini,Andreas Greinacher,Stanley L. Hazen,Marjo-Riitta Järvelin,Kay-Tee Khaw,Terho Lehtimäki,Winfried Maerz,Nicholas G. Martin,Andres Metspalu,Braxton D. Mitchell,Grant W. Montgomery,Carmel Moore,Gerjan Navis,Mario Pirastu,Peter P. Pramstaller,Ramiro Ramirez-Solis,Eric E. Schadt,James Scott,Alan R. Shuldiner,George Davey Smith,J. Gustav Smith,Harold Snieder,Rossella Sorice,Tim D. Spector,Kari Stefansson,Michael Stumvoll,W.H. Wilson Tang,Daniela Toniolo,Anke Tönjes,Peter M. Visscher,Peter Vollenweider,Nicholas J. Wareham,Bruce H. R. Wolffenbuttel,Dorret I. Boomsma,Jacques S. Beckmann,George Dedoussis,Panos Deloukas,Manuel A. R. Ferreira,Serena Sanna,Manuela Uda,Andrew A. Hicks,Josef M. Penninger,Christian Gieger,Jaspal S. Kooner,Willem H. Ouwehand,Nicole Soranzo,John C. Chambers +194 more
TL;DR: A genome-wide association study of haemoglobin concentration and related parameters in up to 135,367 individuals identifies 75 independent genetic loci associated with one or more red blood cell phenotypes at P < 10−8, which together explain 4–9% of the phenotypic variance per trait.