G
Gordon H. Guyatt
Researcher at McMaster University
Publications - 1749
Citations - 262329
Gordon H. Guyatt is an academic researcher from McMaster University. The author has contributed to research in topics: Randomized controlled trial & Medicine. The author has an hindex of 231, co-authored 1620 publications receiving 228631 citations. Previous affiliations of Gordon H. Guyatt include Memorial Sloan Kettering Cancer Center & Cayetano Heredia University.
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Individuals with diabetes preferred that future trials use patient-important outcomes and provide pragmatic inferences.
Mohammad Hassan Murad,Nilay Shah,Holly K. Van Houten,Jeanette Y. Ziegenfuss,James R. Deming,Timothy J. Beebe,Steven A. Smith,Gordon H. Guyatt,Victor M. Montori +8 more
TL;DR: In this article, patients with diabetes report a strong preference for practical trials measuring the effect of treatments on patient-important outcomes, and patients with poor glycemic control were more likely to prefer HbA1c as a primary end point (odds ratio: 1.5; 95% confidence interval: 1, 2.1).
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Hip fracture evaluation with alternatives of total hip arthroplasty versus hemiarthroplasty (HEALTH): protocol for a multicentre randomised trial
Mohit Bhandari,Philip J. Devereaux,Thomas A. Einhorn,Lehana Thabane,Emil H. Schemitsch,Kenneth J. Koval,Frede Frihagen,Rudolf W. Poolman,Kevin Tetsworth,Ernesto Guerra-Farfán,Kim Madden,Sheila Sprague,Gordon H. Guyatt +12 more
TL;DR: The HEALTH trial compares outcomes following THA versus HA in patients 50 years of age or older with displaced femoral neck fractures and is using minimisation to ensure balance between intervention groups for the following factors: age, prefracture living, prefractional status, American Society for Anesthesiologists (ASA) Class and centre number.
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Corticosteroids for treatment of sore throat: systematic review and meta-analysis of randomised trials
Behnam Sadeghirad,Behnam Sadeghirad,Reed A C Siemieniuk,Romina Brignardello-Petersen,Romina Brignardello-Petersen,Davide Papola,Lyubov Lytvyn,Per Olav Vandvik,Per Olav Vandvik,Arnaud Merglen,Gordon H. Guyatt,Thomas Agoritsas +11 more
TL;DR: Single low dose corticosteroids can provide pain relief in patients with sore throat, with no increase in serious adverse effects.
Journal ArticleDOI
Patent foramen ovale closure, antiplatelet therapy or anticoagulation in patients with patent foramen ovale and cryptogenic stroke: a systematic review and network meta-analysis incorporating complementary external evidence.
Hassan Mir,Reed Alexander Siemieniuk,Long Cruz Ge,Farid Foroutan,Michael Fralick,Talha Syed,Luciane Cruz Lopes,Ton Kuijpers,Jean-Louis Mas,Per Olav Vandvik,Per Olav Vandvik,Thomas Agoritsas,Gordon H. Guyatt +12 more
TL;DR: In patients aged <60 years, PFO closure probably confers an important reduction in ischaemic stroke recurrence compared with antiplatelet therapy alone but may make no difference compared with anticoagulation.
Stopping Randomized Trials Early for Benefit and Estimation of Treatment Effects
Dirk Bassler,Matthias Briel,Victor M. Montori,Paul Glasziou,Qi Zhou,Diane Heels-Ansdell,Stephen D. Walter,Gordon H. Guyatt +7 more
TL;DR: Tuncated RCTs were associated with greater effect sizes than R CTs not stopped early and this difference was independent of the presence of statistical stopping rules and was greatest in smaller studies.