G
Gordon H. Guyatt
Researcher at McMaster University
Publications - 1749
Citations - 262329
Gordon H. Guyatt is an academic researcher from McMaster University. The author has contributed to research in topics: Randomized controlled trial & Medicine. The author has an hindex of 231, co-authored 1620 publications receiving 228631 citations. Previous affiliations of Gordon H. Guyatt include Memorial Sloan Kettering Cancer Center & Cayetano Heredia University.
Papers
More filters
Journal ArticleDOI
Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit.
Francois Lamontagne,Marie-Hélène Masse,Julie Ménard,Sheila Sprague,Ruxandra Pinto,Daren K. Heyland,Deborah J. Cook,Marie-Claude Battista,Andrew G. Day,Gordon H. Guyatt,Salmaan Kanji,Rachael Parke,Shay McGuinness,Bharath Kumar Tirupakuzhi Vijayaraghavan,Djillali Annane,Dian Cohen,Yaseen M. Arabi,Brigitte Bolduc,Nicole Marinoff,Bram Rochwerg,Tina Millen,Maureen O. Meade,Lori Hand,Irene Watpool,Rebecca Porteous,Paul J Young,Frédérick D’Aragon,Emilie P. Belley-Côté,E. Carbonneau,F Clarke,David M. Maslove,Miranda Hunt,Michaël Chassé,Martine Lebrasseur,François Lauzier,Shamir R. Mehta,Hector Quiroz-Martinez,Oleksa G. Rewa,Emmanuel Charbonney,Andrew J.E. Seely,Demetrios J. Kutsogiannis,Rémi LeBlanc,Armand Mekontso-Dessap,Tina S Mele,Alexis F. Turgeon,Gordon Wood,Sandeep Kohli,Jason Shahin,Paweł Twardowski,Neill K. J. Adhikari +49 more
TL;DR: In adults with sepsis receiving vasopressor therapy in the ICU, those who received intravenous vitamin C had a higher risk of death or persistent organ dysfunction at 28 days thanThose who received placebo.
Journal ArticleDOI
World Health Organization strong recommendations based on low-quality evidence (study quality) are frequent and often inconsistent with GRADE guidance
Paul E. Alexander,Juan P. Brito,Ignacio Neumann,Ignacio Neumann,Michael R. Gionfriddo,Lisa Bero,Benjamin Djulbegovic,Rebecca J. Stoltzfus,Victor M. Montori,Susan L Norris,Holger J. Schünemann,Gordon H. Guyatt +11 more
TL;DR: WHO discordant recommendations are often inconsistent with GRADE guidance, possibly threatening the integrity of the process and further training in GRADE methods for WHO guideline development group members may be necessary.
Journal ArticleDOI
Systematic reviewers commonly contact study authors but do so with limited rigor.
Rebecca J. Mullan,David N. Flynn,David N. Flynn,Bo Carlberg,Imad M. Tleyjeh,Imad M. Tleyjeh,Celia C. Kamath,Matthew L. LaBella,Matthew L. LaBella,Patricia J. Erwin,Gordon H. Guyatt,Victor M. Montori +11 more
TL;DR: Although common, author contact is not a universal feature of systematic reviews published in top journals and the Cochrane Library, and the conduct and reporting of author contact purpose, procedures, and results require improvement.
Journal ArticleDOI
Gastrointestinal bleeding prophylaxis for critically ill patients: a clinical practice guideline.
Zhikang Ye,Zhikang Ye,Annika Reintam Blaser,Lyubov Lytvyn,Ying Wang,Gordon H. Guyatt,J Stephen Mikita,Jamie Roberts,Thomas Agoritsas,Sonja Bertschy,Filippo Boroli,Julie Camsooksai,Bin Du,Anja Fog Heen,Jianyou Lu,José M. Mella,Per Olav Vandvik,Robert Wise,Robert Wise,Yue Zheng,Lihong Liu,Reed A C Siemieniuk +21 more
TL;DR: In most critically ill patients, the reduction in clinically important gastrointestinal bleeding from gastric acid suppressants is closely balanced with the possibility of pneumonia.
Journal ArticleDOI
Comparative Effectiveness of Phosphate Binders in Patients with Chronic Kidney Disease: A Systematic Review and Network Meta-Analysis
Nigar Sekercioglu,Lehana Thabane,Juan Pablo Diaz Martinez,Gihad Nesrallah,Christopher J. Longo,Jason W. Busse,Noori Akhtar-Danesh,Arnav Agarwal,Reem Al-Khalifah,Alfonso Iorio,Gordon H. Guyatt +10 more
TL;DR: Use of calcium results in higher mortality than either sevelamer in particular and NCBPBs in general (moderate quality evidence), which raises questions about whether administration of calcium as an intervention for CKD- MBD remains ethical.