G
Gordon H. Guyatt
Researcher at McMaster University
Publications - 1749
Citations - 262329
Gordon H. Guyatt is an academic researcher from McMaster University. The author has contributed to research in topics: Randomized controlled trial & Medicine. The author has an hindex of 231, co-authored 1620 publications receiving 228631 citations. Previous affiliations of Gordon H. Guyatt include Memorial Sloan Kettering Cancer Center & Cayetano Heredia University.
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Journal ArticleDOI
Blinded interpretation of study results can feasibly and effectively diminish interpretation bias.
Teppo L. N. Järvinen,Raine Sihvonen,Mohit Bhandari,Sheila Sprague,Antti Malmivaara,Mika Paavola,Holger J. Schünemann,Gordon H. Guyatt +7 more
TL;DR: In this article, the authors describe two applications of an approach that involves blinded interpretation of the results by study investigators, which may decrease the frequency of misleading data interpretation in randomized controlled trials.
Journal ArticleDOI
Randomized trials versus observational studies in adolescent pregnancy prevention.
TL;DR: Observational studies yield systematically greater estimates of treatment effects than randomized trials of adolescent pregnancy prevention interventions and public policy or individual patient treatment decisions should be based on observational studies only when randomized trials are unavailable.
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Accelerated care versus standard care among patients with hip fracture: the HIP ATTACK pilot trial
Care Track Investigators,Giovanna Lurati Buse,Mohit Bhandari,Parag Sancheti,Steve Rocha,Mitchell Winemaker,Anthony Adili,Justin de Beer,Maria Tiboni,John Neary,Valerie Dunlop,Leslie Gauthier,Ameen Patel,Andrea Robinson,Reitze N. Rodseth,Rick Kolesar,J. Farrell,Mark Crowther,Vikas Tandon,Patrick Magloire,Hisham Dokainish,Philip Joseph,Charles W. Tomlinson,Omid Salehian,Debbie Hastings,Dereck L. Hunt,Harriette G.C. Van Spall,Tammy Cosman,Diane Simpson,David Cowan,Gordon H. Guyatt,Kim Alvarado,W.K. (Bill) Evans,Ryszard Mizera,John W. Eikelboom,Deborah J. Cook,Mark Loeb,Jennie Johnstone,Clive Kearon,Daniel I. Sessler,Thomas VanHelder,Purnima Rao-Melacini,Andrew Worster,Atul Patil,Richard George McLean,Anne-Marie Macdonald,Rick Badzioch,Philip J. Devereaux +47 more
TL;DR: These results show the feasibility of a trial comparing accelerated and standard care among patients with hip fracture and support a definitive trial, and the main clinical outcome was a major perioperative complication.
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Clopidogrel plus aspirin versus aspirin alone for acute minor ischaemic stroke or high risk transient ischaemic attack: systematic review and meta-analysis
Qiukui Hao,Malavika P. Tampi,Martin O'Donnell,Farid Foroutan,Reed A C Siemieniuk,Gordon H. Guyatt +5 more
TL;DR: Dual antiplatelet therapy with clopidogrel and aspirin given within 24 hours after high risk TIA or minor ischaemic stroke reduces subsequent stroke by about 20 in 1000 population, with a possible increase in moderate to severe bleeding of 2 per 1000 population.
Journal ArticleDOI
GRADE approach to drawing conclusions from a network meta-analysis using a minimally contextualised framework
Romina Brignardello-Petersen,Ivan D. Florez,Ariel Izcovich,Nancy Santesso,Glen Hazlewood,Waleed Alhazanni,Juan José Yepes-Nuñez,George Tomlinson,Holger J. Schünemann,Gordon H. Guyatt +9 more
TL;DR: The guidance uses a minimally contextualised approach that avoids value judgments regarding the magnitude of intervention effects and is simple, methodologically sound, and flexible, allowing for modifications to resolve situations in which additional complexity or value judgments might be appropriate.