G
Gordon H. Guyatt
Researcher at McMaster University
Publications - 1749
Citations - 262329
Gordon H. Guyatt is an academic researcher from McMaster University. The author has contributed to research in topics: Randomized controlled trial & Medicine. The author has an hindex of 231, co-authored 1620 publications receiving 228631 citations. Previous affiliations of Gordon H. Guyatt include Memorial Sloan Kettering Cancer Center & Cayetano Heredia University.
Papers
More filters
Journal ArticleDOI
Ethical Issues in Stopping Randomized Trials Early Because of Apparent Benefit
TL;DR: It is argued that stopping a randomized trial early for apparent benefit is often unethical and can be justified only under restricted circumstances and the scientific validity of trials that are stopped early is further compromised when trials yield inconclusive data about outcomes that did not influence trial truncation.
Journal ArticleDOI
The Sixth (2000) ACCP Guidelines for Antithrombotic Therapy for Prevention and Treatment of Thrombosis
TL;DR: The American College of Chest Physicians (ACCP) Task Force on Antithrombotic Therapy published the proceedings of their first consensus conference on antithromboembolic therapy in 1986.
Journal ArticleDOI
Venom immunotherapy improves health-related quality of life in patients allergic to yellow jacket venom
Joanne N.G. Oude Elberink,Jan G.R. de Monchy,Sicco van der Heide,Gordon H. Guyatt,Anthony E.J. Dubois +4 more
TL;DR: VIT results in a clinically important improvement in HRQL in patients allergic to yellow jacket venom in all subgroups studied, and this improvement was statistically significant.
Journal ArticleDOI
Electronic nicotine delivery systems and/or electronic non-nicotine delivery systems for tobacco smoking cessation or reduction: a systematic review and meta-analysis.
Regina El Dib,Regina El Dib,Erica Aranha Suzumura,Elie A. Akl,Elie A. Akl,Huda Gomaa,Arnav Agarwal,Arnav Agarwal,Yaping Chang,Manya Prasad,Vahid Ashoorion,Vahid Ashoorion,Diane Heels-Ansdell,Wasim Maziak,Gordon H. Guyatt +14 more
TL;DR: There is very limited evidence regarding the impact of ENDS or ENNDS on tobacco smoking cessation, reduction or adverse effects: data from RCTs are of low certainty and observational studies of very low certainty.
Journal ArticleDOI
New strategies for clinical trials in patients with sepsis and septic shock.
Jonathan Cohen,Gordon H. Guyatt,Gordon R. Bernard,Thierry Calandra,Deborah J. Cook,Diana Elbourne,John Marshall,Andrew J. Nunn,Steven M. Opal +8 more
TL;DR: Important changes in several aspects of trial design may improve the quality of clinical studies in sepsis and maximize the chance of identifying effective therapeutic agents.