D
Dorothee Diogo
Researcher at Harvard University
Publications - 7
Citations - 2272
Dorothee Diogo is an academic researcher from Harvard University. The author has contributed to research in topics: Genome-wide association study & Allele. The author has an hindex of 4, co-authored 4 publications receiving 1884 citations. Previous affiliations of Dorothee Diogo include Broad Institute.
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Journal ArticleDOI
Genetics of rheumatoid arthritis contributes to biology and drug discovery
Yukinori Okada,Yukinori Okada,Di Wu,Di Wu,Di Wu,Gosia Trynka,Gosia Trynka,Towfique Raj,Towfique Raj,Chikashi Terao,Katsunori Ikari,Yuta Kochi,Koichiro Ohmura,Akari Suzuki,Shinji Yoshida,Robert R. Graham,A. Manoharan,Ward Ortmann,Tushar Bhangale,Joshua C. Denny,Robert J. Carroll,Anne E. Eyler,Jeff Greenberg,Joel M. Kremer,Dimitrios A. Pappas,Lei Jiang,Jian Yin,Lingying Ye,Ding Feng Su,Jian Yang,Gang Xie,E.C. Keystone,Harm-Jan Westra,Tõnu Esko,Tõnu Esko,Tõnu Esko,Andres Metspalu,Xuezhong Zhou,Namrata Gupta,Daniel B. Mirel,Eli A. Stahl,Dorothee Diogo,Dorothee Diogo,Jing Cui,Jing Cui,Katherine P. Liao,Katherine P. Liao,Michael H. Guo,Michael H. Guo,Keiko Myouzen,Takahisa Kawaguchi,Marieke J H Coenen,Piet L. C. M. van Riel,Mart A F J van de Laar,Henk-Jan Guchelaar,Tom W J Huizinga,Philippe Dieudé,Xavier Mariette,S. Louis Bridges,Alexandra Zhernakova,Alexandra Zhernakova,René E. M. Toes,Paul P. Tak,Paul P. Tak,Paul P. Tak,Corinne Miceli-Richard,So Young Bang,Hye Soon Lee,Javier Martin,Miguel A. Gonzalez-Gay,Luis Rodriguez-Rodriguez,Solbritt Rantapää-Dahlqvist,Lisbeth Ärlestig,Hyon K. Choi,Hyon K. Choi,Yoichiro Kamatani,Pilar Galan,Mark Lathrop,Steve Eyre,Steve Eyre,John Bowes,John Bowes,Anne Barton,Niek de Vries,Larry W. Moreland,Lindsey A. Criswell,Elizabeth W. Karlson,Atsuo Taniguchi,Ryo Yamada,Michiaki Kubo,Jun Liu,Sang Cheol Bae,Jane Worthington,Jane Worthington,Leonid Padyukov,Lars Klareskog,Peter K. Gregersen,Soumya Raychaudhuri,Soumya Raychaudhuri,Barbara E. Stranger,Philip L. De Jager,Philip L. De Jager,Lude Franke,Peter M. Visscher,Matthew A. Brown,Hisashi Yamanaka,Tsuneyo Mimori,Atsushi Takahashi,Huji Xu,Timothy W. Behrens,Katherine A. Siminovitch,Shigeki Momohara,Fumihiko Matsuda,Kazuhiko Yamamoto,Robert M. Plenge,Robert M. Plenge +115 more
TL;DR: A genome-wide association study meta-analysis in a total of >100,000 subjects of European and Asian ancestries provides empirical evidence that the genetics of RA can provide important information for drug discovery, and sheds light on fundamental genes, pathways and cell types that contribute to RA pathogenesis.
Journal ArticleDOI
Genome-wide association study and gene expression analysis identifies CD84 as a predictor of response to etanercept therapy in rheumatoid arthritis
Jing Cui,Eli A. Stahl,Eli A. Stahl,Eli A. Stahl,Saedis Saevarsdottir,Corinne Miceli,Corinne Miceli,Dorothee Diogo,Dorothee Diogo,Gosia Trynka,Gosia Trynka,Towfique Raj,Towfique Raj,Maša Umiċeviċ Mirkov,Helena Canhão,Helena Canhão,Katsunori Ikari,Chikashi Terao,Yukinori Okada,Yukinori Okada,Sara Wedrén,Johan Askling,Hisashi Yamanaka,Shigeki Momohara,Atsuo Taniguchi,Koichiro Ohmura,Fumihiko Matsuda,Tsuneyo Mimori,Namrata Gupta,Manik Kuchroo,Manik Kuchroo,Ann W. Morgan,John D. Isaacs,Anthony G. Wilson,Kimme L. Hyrich,M M J Herenius,Marieke E. Doorenspleet,Paul P. Tak,Paul P. Tak,J. Bart A. Crusius,Irene E. van der Horst-Bruinsma,Gertjan Wolbink,Gertjan Wolbink,Piet L. C. M. van Riel,Mart A F J van de Laar,Henk-Jan Guchelaar,Nancy A. Shadick,Cornelia F Allaart,Tom W J Huizinga,René E. M. Toes,Robert P. Kimberly,S. Louis Bridges,Lindsey A. Criswell,Larry W. Moreland,João Eurico Fonseca,Niek de Vries,Barbara E. Stranger,Barbara E. Stranger,Philip L. De Jager,Philip L. De Jager,Philip L. De Jager,Soumya Raychaudhuri,Soumya Raychaudhuri,Michael E. Weinblatt,Peter K. Gregersen,Xavier Mariette,Xavier Mariette,Anne Barton,Leonid Padyukov,Marieke J H Coenen,Elizabeth W. Karlson,Robert M. Plenge,Robert M. Plenge +72 more
TL;DR: A genome-wide association study of more than 2 million common variants in rheumatoid arthritis patients shows that an allele associated with response to etanercept therapy is also associated with CD84 gene expression, and further that CD84 expression correlates with disease activity.
Journal ArticleDOI
Integration of sequence data from a consanguineous family with genetic data from an outbred population identifies PLB1 as a candidate rheumatoid arthritis risk gene
Yukinori Okada,Dorothee Diogo,Dorothee Diogo,Jeff Greenberg,Faten Mouassess,Walid A L Achkar,Robert S. Fulton,Joshua C. Denny,Namrata Gupta,Daniel B. Mirel,S. Gabriel,Gang Li,Joel M. Kremer,Dimitrios A. Pappas,Robert J. Carroll,Anne E. Eyler,Gosia Trynka,Gosia Trynka,Eli A. Stahl,Jing Cui,Richa Saxena,Marieke J H Coenen,Henk-Jan Guchelaar,Tom W J Huizinga,Philippe Dieudé,Xavier Mariette,Anne Barton,Helena Canhão,João Eurico Fonseca,Niek de Vries,Paul P. Tak,Larry W. Moreland,S. Louis Bridges,Corinne Miceli-Richard,Hyon K. Choi,Hyon K. Choi,Yoichiro Kamatani,Pilar Galan,Mark Lathrop,Towfique Raj,Towfique Raj,Philip L. De Jager,Philip L. De Jager,Soumya Raychaudhuri,Jane Worthington,Leonid Padyukov,Lars Klareskog,Katherine A. Siminovitch,Peter K. Gregersen,Elaine R. Mardis,Thurayya Arayssi,L. Kazkaz,Robert M. Plenge,Robert M. Plenge +53 more
TL;DR: It is demonstrated that rare, low-frequency and common alleles at one gene locus, phospholipase B1 (PLB1), might contribute to risk of RA in a 4-generation consanguineous pedigree and also in unrelated individuals from the general population (European ancestry).
Journal ArticleDOI
Human Genetics in Rheumatoid Arthritis Guides a High-Throughput Drug Screen of the CD40 Signaling Pathway
Gang Li,Dorothee Diogo,Dorothee Diogo,Di Wu,Jim Spoonamore,Vlado Dančík,Lude Franke,Fina A S Kurreeman,Fina A S Kurreeman,Elizabeth J. Rossin,Elizabeth J. Rossin,Grant Duclos,Cathy L Hartland,Xuezhong Zhou,Kejie Li,Jun Liu,Philip L. De Jager,Philip L. De Jager,Katherine A. Siminovitch,Alexandra Zhernakova,Alexandra Zhernakova,Soumya Raychaudhuri,Soumya Raychaudhuri,John Bowes,Steve Eyre,Leonid Padyukov,Peter K. Gregersen,Jane Worthington,Namrata Gupta,Paul A. Clemons,Eli A. Stahl,Eli A. Stahl,Nicola Tolliday,Robert M. Plenge,Robert M. Plenge +34 more
TL;DR: This study demonstrates proof-of-concept that human genetics can be used to guide the development of phenotype-based, high-throughput small-molecule screens to identify potential novel therapies in complex traits such as RA.
Journal ArticleDOI
Using human genetics to improve safety assessment of therapeutics
Keren J. Carss,Aimee M. Deaton,Alberto del Río-Espínola,Dorothee Diogo,Mark R. Fielden,Diptee Kulkarni,Jonathan G. Moggs,Peter Newham,Matthew R. Nelson,Frank D. Sistare,Lucas D. Ward,Jing Yuan +11 more
TL;DR: Applications of human genetics to safety studies during drug discovery and development, including assessing the potential for on- and off-target associated adverse events, carcinogenicity risk assessment, and guiding translational safety study designs and monitoring strategies are illustrated.