James J. Collins

TL;DR: In this article, the authors presented a method for using engineered microorganisms to sense and destroy pathogens (e.g., Vibrio cholerae) using hybrid receptors and genetic circuits.

TL;DR: In this paper , the authors explore how their research expanded beyond free-living planarians to their gruesome parasitic cousins, Schistosoma mansoni, and the rat tapeworm Hymenolepis diminuta, a model that had been largely forgotten by the molecular biology revolution.

TL;DR: A generally applicable framework that utilizes massively parallel single-cell RNA-seq to compare cell types and states found in vivo to those of in vitro models such as organoids is presented and it is predicted that the generation of rationally improved cellular models will facilitate mechanistic exploration of specific disease-associated genes in their respective cell types.

TL;DR: Despite having an increasingly accurate parts list for biological cells, much is left to discover about how these parts act together to create functional cells, and how distinct individual cells interact to createfunctional tissues and organs.

TL;DR: In this paper, the authors studied the natural history of pulmonary function in correlation to motor function in the collagen VI-related myopathies by analyzing longitudinal forced vital capacity data in a large international cohort.