James J. Collins

TL;DR: Reanalyses of the National Cancer Institute cohort study on nasopharyngeal cancer (NPC) risk among formaldehyde exposed workers (Hauptmann et al., 2004) are performed and readers are asked for a prompt corrigendum of the 2004 publication.

TL;DR: The development of the criteria used to evaluate manuscripts is described, with respect to improving the science of evaluation methodology, promoting the highest ethical standards in intervention evaluation, and using the current criteria as a starting point for continuing to raise the bar for evaluation methodology.

TL;DR: An experimental platform to simplify complex communities of fecal bacteria through dilution and rapidly screen for their ability to resist C. difficile colonization resistance is developed and four new simplified communities of microbes with potential for development of new therapies to treat C.difficile disease are identified.

TL;DR: In this article , the authors identify a mechanism of tolerance evolution in E. coli involving deletion of the sodium-proton antiporter gene nhaA, which results in downregulated metabolism and upregulated stress responses, and find that cycling of antibiotics with different metabolic dependencies interrupts evolution of tolerance in vitro, increasing the lifetime of treatment efficacy.