J
James J. Collins
Researcher at Massachusetts Institute of Technology
Publications - 700
Citations - 105255
James J. Collins is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Synthetic biology & Population. The author has an hindex of 151, co-authored 669 publications receiving 89476 citations. Previous affiliations of James J. Collins include Baylor College of Medicine & University at Albany, SUNY.
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Journal ArticleDOI
Reliability and validity of the Stanford Presenteeism Scale.
Robin S. Turpin,Ronald J. Ozminkowski,Claire Sharda,James J. Collins,Marc L. Berger,Gary M. Billotti,Catherine M. Baase,Michael J Olson,Sean Nicholson +8 more
TL;DR: The SPS demonstrates a high degree of reliability and validity and may be ideal for employers who seek a single scale to measure health-related productivity in a diverse employee population.
Journal ArticleDOI
Tunable protein degradation in bacteria
D. Ewen Cameron,James J. Collins +1 more
TL;DR: In this article, the Mesoplasma florum transfer-messenger RNA system is used to create a synthetic degradation system that provides both independent control of steady-state protein level and inducible degradation of targeted proteins in Escherichia coli.
Bactericidal Antibiotics Induce Toxic Metabolic Perturbations that Lead to Cellular Damage
Peter Belenky,Jonathan D. Ye,Nadia Cohen,Thomas C. Ferrante,Saloni R. Jain,Benjamin J. Korry,Eric G. Schwarz,Graham C. Walker,James J. Collins,Caroline B. M. Porter,Michael A. Lobritz +10 more
TL;DR: It is shown that bactericidal antibiotics induce a complex set of metabolic changes that are correlated with the buildup of toxic metabolic by-products, and potential end-target consequences of these metabolic perturbations are examined.
Journal ArticleDOI
Wearable materials with embedded synthetic biology sensors for biomolecule detection.
Peter Q. Nguyen,Peter Q. Nguyen,Luis R. Soenksen,Luis R. Soenksen,Nina M. Donghia,Nicolaas M. Angenent-Mari,Nicolaas M. Angenent-Mari,Helena de Puig,Helena de Puig,Ally Huang,Ally Huang,Rose A. Lee,Shimyn Slomovic,Tommaso Galbersanini,Geoffrey Lansberry,Hani M. Sallum,Evan M. Zhao,James B. Niemi,James J. Collins +18 more
TL;DR: In this article, a face mask with a lyophilized CRISPR sensor for wearable, noninvasive detection of SARS-CoV-2 at room temperature within 90 min, requiring no user intervention other than the press of a button.
Journal ArticleDOI
Adult somatic stem cells in the human parasite Schistosoma mansoni
TL;DR: Using RNA interference it is demonstrated that this gene is required for the maintenance of these neoblast-like cells in the trematode Schistosoma mansoni, indicating that adaptation of developmental strategies shared by free-living ancestors to modern-day schistosomes probably contributed to the success of these animals as long-lived obligate parasites.