J
James J. Collins
Researcher at Massachusetts Institute of Technology
Publications - 700
Citations - 105255
James J. Collins is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Synthetic biology & Population. The author has an hindex of 151, co-authored 669 publications receiving 89476 citations. Previous affiliations of James J. Collins include Baylor College of Medicine & University at Albany, SUNY.
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Journal ArticleDOI
Genotype-phenotype correlations in recessive RYR1-related myopathies
Kimberly Amburgey,Angela M. Bailey,Jean H. Hwang,Mark A. Tarnopolsky,Carsten G. Bönnemann,Livija Medne,Katherine D. Mathews,James J. Collins,Jasper R. Daube,Gregory P Wellman,Brian C. Callaghan,Nigel F. Clarke,James J. Dowling +12 more
TL;DR: The results support a hypothesis that loss of protein function is a key predictive disease parameter and suggest that decreased RyR1 expression may dictate non-core related pathology though, data on protein expression was limited and should be confirmed in a larger cohort.
Journal ArticleDOI
Lymphohaematopoeitic cancer mortality among workers with benzene exposure
TL;DR: The observed number of deaths is small, and the number of peak exposures greater than 100 ppm to benzene is a better predictor of risk than cumulative exposure, which may be important factors for evaluating lymphohaematopoietic risk.
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High-throughput creation and functional profiling of DNA sequence variant libraries using CRISPR-Cas9 in yeast.
Xiaoge Guo,Alejandro Chavez,Angela Tung,Yingleong Chan,Yingleong Chan,Christian Schrøder Kaas,Christian Schrøder Kaas,Christian Schrøder Kaas,Yi Yin,Ryan J Cecchi,Santiago Lopez Garnier,Eric D. Kelsic,Eric D. Kelsic,Max G. Schubert,Max G. Schubert,James E. DiCarlo,James E. DiCarlo,James E. DiCarlo,James J. Collins,George M. Church,George M. Church +20 more
TL;DR: In this article, a Cas9-based approach for generating pools of mutants with defined genetic alterations (deletions, substitutions, and insertions) with an efficiency of 80-100% in yeast, along with methods for tracking their fitness en masse.
Journal ArticleDOI
Synchronization of noisy systems by stochastic signals.
Alexander Neiman,Lutz Schimansky-Geier,Lutz Schimansky-Geier,Frank Moss,Boris Shulgin,James J. Collins +5 more
TL;DR: It is shown that dichotomic noise can instantaneously synchronize the switching process of the system and is most pronounced at an optimal noise level-this effect connects this phenomenon with aperiodic stochastic resonance.
Journal ArticleDOI
Publisher Correction: Definitions and guidelines for research on antibiotic persistence.
Nathalie Q. Balaban,Sophie Helaine,Kim Lewis,Martin Ackermann,Martin Ackermann,Bree B. Aldridge,Dan I. Andersson,Mark P. Brynildsen,Dirk Bumann,Andrew Camilli,James J. Collins,James J. Collins,James J. Collins,Christoph Dehio,Sarah M. Fortune,Jean Marc Ghigo,Wolf-Dietrich Hardt,Alexander Harms,Matthias Heinemann,Deborah T. Hung,Urs Jenal,Bruce R. Levin,Jan Michiels,Gisela Storz,Man-Wah Tan,Tanel Tenson,Laurence Van Melderen,Annelies S. Zinkernagel +27 more
TL;DR: In Figure 2b, the minimal duration for killing (MDK) 99% of tolerant cells was erroneously labelled as MDK99 instead ofMDK99.99, which has now been corrected in all versions of the Review.