James J. Collins

TL;DR: INDIGO quantifies the influence of individual chemical–genetic interactions on synergy and antagonism and significantly outperforms existing approaches based on experimental evaluation of novel predictions in Escherichia coli, and enables the discovery of effective combination therapies in less‐studied pathogens by leveraging chemogenomics data in model organisms.

TL;DR: This work shows that targeted, engineered phagemid therapy can serve as a viable, nonantibiotic means to treat bacterial infections, while avoiding the health issues inherent to lytic and replicative bacteriophage use.

TL;DR: In this article, the authors conceptualize how synthetic biology approaches can be applied to program living cells with therapeutic functions and discuss the advantages that they offer over conventional therapies in terms of flexibility, specificity and predictability, as well as challenges for their development.

TL;DR: In this article, the authors show that exhaustion of the metabolic inputs that couple carbon catabolism to oxidative phosphorylation is a primary cause of growth phase-dependent persistence to quinolone antibiotics.

TL;DR: An AV nodal conduction model which undergoes a period-doubling bifurcation into alternans is implemented and it is shown that additive noise can be used to locate the unstable period-1 fixed point which underlies the alternans rhythm.