J
James J. Collins
Researcher at Massachusetts Institute of Technology
Publications - 700
Citations - 105255
James J. Collins is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Synthetic biology & Population. The author has an hindex of 151, co-authored 669 publications receiving 89476 citations. Previous affiliations of James J. Collins include Baylor College of Medicine & University at Albany, SUNY.
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Journal ArticleDOI
De novo-designed translation-repressing riboregulators for multi-input cellular logic.
Jongmin Kim,Jongmin Kim,Yu Zhou,Paul D. Carlson,Paul D. Carlson,Mario Teichmann,Chaudhary Soma,Friedrich C. Simmel,Friedrich C. Simmel,Pamela A. Silver,Pamela A. Silver,James J. Collins,James J. Collins,James J. Collins,Julius B. Lucks,Peng Yin,Peng Yin,Alexander A. Green +17 more
TL;DR: De novo RNA design is employed to develop two high-performance translational repressors with sensing and logic capabilities that detect transcripts with nearly arbitrary sequences, repress gene expression by up to 300-fold, and yield orthogonal sets of up to 15 devices.
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A single-cell RNA-seq atlas of Schistosoma mansoni identifies a key regulator of blood feeding.
George R Wendt,Lu Zhao,Rui Chen,Chenxi Liu,Anthony J. O’Donoghue,Conor R. Caffrey,Michael L. Reese,James J. Collins +7 more
TL;DR: Molecular investigations of the parasite Schistosoma mansoni found a gene required for gut development that, when knocked out through RNA interference, confers reduced pathology in infected mice and identified an essential pair of protein kinases that can be targeted by approved pharmacological intervention.
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BioBits™ Bright: A fluorescent synthetic biology education kit.
Jessica C. Stark,Ally Huang,Ally Huang,Peter Q. Nguyen,Peter Q. Nguyen,Rachel S. Dubner,Karen J. Hsu,Thomas C. Ferrante,Mary Anderson,Ada Kanapskyte,Quinn Mucha,Jessica S. Packett,Palak Patel,Richa Patel,Deema Qaq,Tyler Zondor,Julie Burke,Thomas Martinez,Ashlee Miller-Berry,Aparna Puppala,Kara Reichert,Miriam Schmid,Lance Brand,Lander R. Hill,Jemima F. Chellaswamy,Nuhie Faheem,Suzanne Fetherling,Elissa Gong,Eddie Marie Gonzalzles,Teresa Granito,Jenna Koritsaris,Binh Nguyen,Sujud Ottman,Christina Palffy,Angela Patel,Sheila Skweres,Adriane Slaton,Ta Rhonda Woods,Nina M. Donghia,Keith Pardee,James J. Collins,Michael C. Jewett +41 more
TL;DR: BioBits™ Bright is presented, a shelf-stable, just-add-water synthetic biology education kit with easy visual outputs enabled by expression of fluorescent proteins in freeze-dried, cell-free reactions that promise to enhance biology education both inside and outside the classroom.
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A network biology approach to aging in yeast
TL;DR: The reverse-engineered network model correctly identified the known interactions of key regulators in a 10-gene network from the Snf1 signaling pathway, which is required for expression of glucose-repressed genes upon calorie restriction and predicted an unexpected role for transcriptional regulation of the SNF1 gene.
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Reading Shop Windows in Globalized Neighborhoods: Multilingual Literacy Practices and Indexicality.
James J. Collins,Stef Slembrouck +1 more
TL;DR: In this paper, shop and cafe signs in multiple languages are examined in polyglot immigrant neighborhoods, presenting photographic, observational, and interview data from interviews with the owners of the businesses.