James J. Collins

TL;DR: In this paper, a massively parallel single-cell RNA-seq framework was proposed to compare cell types and states found in vivo to those of in vitro models such as organoids.

TL;DR: This work establishes a synthetic biology framework for endowing mammalian cells with sentinel capabilities, which provides a programmable means to cull infected cells and increases the repertoire of inducible parts in synthetic biology.

TL;DR: It is demonstrated that by altering the length of Cas9-associated guide RNA (gRNA) it is able to control Cas9 nuclease activity and simultaneously perform genome editing and transcriptional regulation with a single Cas9 protein.

TL;DR: A large-scale RNA interference screen in adult Schistosoma mansoni is described that examined the function of 2216 genes, including 261 genes with phenotypes affecting neuromuscular function, tissue integrity, stem cell maintenance, and parasite survival and uncovered a pair of protein kinases that cooperate to maintain muscle-specific messenger RNA transcription.

TL;DR: It was found that the effective stochastic activity of the open-loop postural control schemes in three of the four crew members was increased following space-flight, indicating that although there may be in-flight adaptations to the vestibular system and/or proprioceptive system, input from the visual system can compensate for such changes during undisturbed stance.