J
James J. Collins
Researcher at Massachusetts Institute of Technology
Publications - 700
Citations - 105255
James J. Collins is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Synthetic biology & Population. The author has an hindex of 151, co-authored 669 publications receiving 89476 citations. Previous affiliations of James J. Collins include Baylor College of Medicine & University at Albany, SUNY.
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Journal ArticleDOI
An enhanced CRISPR repressor for targeted mammalian gene regulation
Nan Cher Yeo,Alejandro Chavez,Alissa Lance-Byrne,Yingleong Chan,Yingleong Chan,David J. Menn,Denitsa Milanova,Denitsa Milanova,Chih-Chung Kuo,Xiaoge Guo,Xiaoge Guo,Sumana Sharma,Angela Tung,Ryan J Cecchi,Marcelle Tuttle,Swechchha Pradhan,Elaine T. Lim,Elaine T. Lim,Noah Davidsohn,Noah Davidsohn,Mo R. Ebrahimkhani,Mo R. Ebrahimkhani,James J. Collins,Nathan E. Lewis,Samira Kiani,George M. Church,George M. Church +26 more
TL;DR: An improved Cas9 repressor based on the C-terminal fusion of a rationally designed bipartite repressor domain, KRAB–MeCP2, to nuclease-dead Cas9 is described, demonstrating the system’s superiority in silencing coding and noncoding genes and enabling new architectures of synthetic genetic circuits.
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Age-related changes in open-loop and closed-loop postural control mechanisms.
James J. Collins,C. J. De Luca,Adam B. Burrows,Adam B. Burrows,Lewis A. Lipsitz,Lewis A. Lipsitz,Lewis A. Lipsitz +6 more
TL;DR: Stabilogram-diffusion analysis was used to examine how the natural aging process affects the operational characteristics of open-loop and closed-loop postural control mechanisms in the elderly, and it was demonstrated cross-sectionally that healthy aging is associated with significant changes in the ‘quasi-static’ dynamics of the posturalcontrol system.
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Noise in human muscle spindles
Paul Cordo,J. T. Inglis,Sabine Verschueren,James J. Collins,Daniel M. Merfeld,S Rosenblum,S Buckley,Frank Moss +7 more
Journal ArticleDOI
Reduced hip extension during walking: healthy elderly and fallers versus young adults.
TL;DR: An isolated and consistent reduction in hip extension during walking in the elderly implies the presence of functionally significant hip tightness, which may limit walking performance.
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A tunable genetic switch based on RNAi and repressor proteins for regulating gene expression in mammalian cells.
TL;DR: A system for tight, tunable control of mammalian gene expression that can be used to explore the functional role of various genes as well as to determine whether a phenotype is the result of a threshold response to changes in gene expression is established.