J
Jennifer A. Flegg
Researcher at University of Melbourne
Publications - 75
Citations - 4037
Jennifer A. Flegg is an academic researcher from University of Melbourne. The author has contributed to research in topics: Malaria & Medicine. The author has an hindex of 24, co-authored 60 publications receiving 3445 citations. Previous affiliations of Jennifer A. Flegg include Monash University & University of Oxford.
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Journal ArticleDOI
Spread of Artemisinin Resistance in Plasmodium falciparum Malaria
Elizabeth A. Ashley,Mehul Dhorda,Rick M. Fairhurst,Chanaki Amaratunga,Pharath Lim,Seila Suon,Sokunthea Sreng,Jennifer M. Anderson,Mao S,Sam B,Chantha Sopha,Char Meng Chuor,Chea Nguon,Siv Sovannaroth,Sasithon Pukrittayakamee,Podjanee Jittamala,Kesinee Chotivanich,K Chutasmit,C Suchatsoonthorn,R Runcharoen,Tran Tinh Hien,Nguyen Thuy-Nhien,Thanh Nv,Nguyen Hoan Phu,Ye Htut,Han Kt,Kyin Hla Aye,Olugbenga A. Mokuolu,Rasaq Olaosebikan,Olaleke Oluwasegun Folaranmi,Mayfong Mayxay,Maniphone Khanthavong,Bouasy Hongvanthong,Paul N. Newton,M A Onyamboko,Caterina I. Fanello,Antoinette Tshefu,Neelima Mishra,Neena Valecha,Aung Pyae Phyo,François Nosten,Yi P,Rupam Tripura,Steffen Borrmann,Mahfudh Bashraheil,Judy Peshu,M A Faiz,Aniruddha Ghose,M A Hossain,Rasheda Samad,M. R. Rahman,Manal Hasan,Ashraful Islam,Olivo Miotto,Roberto Amato,Bronwyn MacInnis,Jim Stalker,Dominic P. Kwiatkowski,Zbynek Bozdech,Atthanee Jeeyapant,Phaik Yeong Cheah,Tharisara Sakulthaew,Jeremy Chalk,Benjamas Intharabut,Kamolrat Silamut,Lee Sj,Benchawan Vihokhern,Chanon Kunasol,Mallika Imwong,Joel Tarning,Taylor Wj,Shunmay Yeung,Charles J. Woodrow,Jennifer A. Flegg,Debashish Das,Jennifer L. Smith,Meera Venkatesan,Christopher V. Plowe,Kasia Stepniewska,Philippe J Guerin,Arjen M. Dondorp,Nicholas P. J. Day,Nicholas J. White +82 more
TL;DR: Prolonged courses of artemisinin-based combination therapies are currently efficacious in areas where standard 3-day treatments are failing, and the incidence of pretreatment and post-treatment gametocytemia was higher among patients with slow parasite clearance, suggesting greater potential for transmission.
Journal ArticleDOI
Spread of artemisinin-resistant Plasmodium falciparum in Myanmar: a cross-sectional survey of the K13 molecular marker
Kyaw Myo Tun,Mallika Imwong,Khin Maung Lwin,Aye A. Win,Tin Maung Hlaing,Thaung Hlaing,Khin Lin,Myat Phone Kyaw,Katherine Plewes,Katherine Plewes,M. Abul Faiz,Mehul Dhorda,Phaik Yeong Cheah,Phaik Yeong Cheah,Sasithon Pukrittayakamee,Elizabeth A. Ashley,Elizabeth A. Ashley,Tim J. Anderson,Shalini Nair,Marina McDew-White,Jennifer A. Flegg,Eric P. M. Grist,Philippe Allard Guérin,Richard J. Maude,Richard J. Maude,Frank Smithuis,Arjen M. Dondorp,Arjen M. Dondorp,Nicholas P. J. Day,Nicholas P. J. Day,François Nosten,Nicholas J. White,Nicholas J. White,Charles J. Woodrow,Charles J. Woodrow +34 more
TL;DR: Assessment of the spread of artemisinin-resistant P falciparum in Myanmar finds Artemisinin resistance extends across much of Myanmar, and Appropriate therapeutic regimens should be tested urgently and implemented comprehensively if spread of warfarin resistance to other regions is to be avoided.
Journal ArticleDOI
Genetic loci associated with delayed clearance of Plasmodium falciparum following artemisinin treatment in Southeast Asia
Shannon Takala-Harrison,Taane G. Clark,Christopher G Jacob,Michael P. Cummings,Olivo Miotto,Olivo Miotto,Arjen M. Dondorp,Mark M. Fukuda,François Nosten,Harald Noedl,Mallika Imwong,Delia Bethell,Youry Se,Chanthap Lon,Stuart D. Tyner,David L. Saunders,Duong Socheat,Frédéric Ariey,A P Phyo,Peter Starzengruber,Hans-Peter Fuehrer,Paul Swoboda,Kasia Stepniewska,Jennifer A. Flegg,Cesar Arze,Gustavo C. Cerqueira,Joana C. Silva,Stacy M. Ricklefs,Stephen F. Porcella,Robert M. Stephens,Matthew Adams,Leo J Kenefic,Susana Campino,Susana Campino,Sarah Auburn,Bronwyn MacInnis,Bronwyn MacInnis,Dominic P. Kwiatkowski,Dominic P. Kwiatkowski,Xin-zhuan Su,Nicholas J. White,Pascal Ringwald,Christopher V. Plowe +42 more
TL;DR: Replication and validation studies are needed to refine the location of loci responsible for artemisinin resistance and to understand the mechanism behind it; however, two SNPs on chromosomes 10 and 13 may be useful markers of delayed parasite clearance in surveillance for artesunate resistance in Southeast Asia.
Journal ArticleDOI
Standardizing the measurement of parasite clearance in falciparum malaria: the parasite clearance estimator
TL;DR: The parasite clearance estimator provides a consistent, reliable and accurate method to estimate the lag phase and malaria parasite clearance rate and could be used to detect early signs of emerging resistance to artemisinin derivatives and other compounds which affect ring-stage clearance.
Journal ArticleDOI
The Effect of Dosing Regimens on the Antimalarial Efficacy of Dihydroartemisinin-Piperaquine: A Pooled Analysis of Individual Patient Data
Jane Achan,Ishag Adam,Emmanuel Arinaitwe,Elizabeth A. Ashley,Ghulam Rahim Awab,Ghulam Rahim Awab,Mamadou S. Ba,Karen I. Barnes,Quique Bassat,Steffen Borrmann,Steffen Borrmann,Teun Bousema,Teun Bousema,Prabin Dahal,Umberto D'Alessandro,Umberto D'Alessandro,Timothy M. E. Davis,Arjen M. Dondorp,Grant Dorsey,Chris Drakeley,Caterina I. Fanello,Babacar Faye,Jennifer A. Flegg,Oumar Gaye,Peter W. Gething,Raquel González,Philippe J Guerin,Simon I. Hay,Tran Tinh Hien,Tran Tinh Hien,Bart Janssens,Moses R. Kamya,Corine Karema,Harin Karunajeewa,Moussa Koné,Bertrand Lell,Kevin Marsh,Kevin Marsh,Mayfong Mayxay,Mayfong Mayxay,Clara Menéndez,Petra F. Mens,Martin M Meremikwu,Clarissa Moreira,Clarissa Moreira,Ivo Mueller,Ivo Mueller,Carolyn Nabasumba,Michael Nambozi,Jean Louis Ndiaye,Paul N. Newton,Paul N. Newton,Thuy Nguyen,François Nosten,François Nosten,Christian Nsanzabana,Sabah A. Omar,Jean-Bosco Ouédraogo,Louis K. Penali,Mbaye Pene,Aung Pyae Phyo,Patrice Piola,Ric N. Price,Ric N. Price,P. Sasithon,Philip J. Rosenthal,Albert Same-Ekobo,Patrick Sawa,Henk D. F. H. Schallig,Seif Shekalaghe,Carol Hopkins Sibley,Jeff Smith,Frank Smithuis,Anyirékun Fabrice Somé,Kasia Stepniewska,Ambrose O. Talisuna,Joel Tarning,Joel Tarning,Emiliana Tjitra,Roger Tine,Halidou Tinto,Neena Valecha,Michel Van Herp,Michèle van Vugt,Nicholas J. White,Nicholas J. White,Charles J. Woodrow,William Yavo,Adoke Yeka,Issaka Zongo +89 more
TL;DR: In this paper, the influence of different dosing schedules on Dihydroartemisinin-piperaquine (DP) clinical efficacy was investigated, and a multivariable model was used to identify risk factors for parasite recrudescence.