J
Johan Rung
Researcher at Science for Life Laboratory
Publications - 32
Citations - 5794
Johan Rung is an academic researcher from Science for Life Laboratory. The author has contributed to research in topics: Gene & Genome-wide association study. The author has an hindex of 21, co-authored 32 publications receiving 5444 citations. Previous affiliations of Johan Rung include Uppsala University & McGill University.
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Journal ArticleDOI
A genome-wide association study identifies novel risk loci for type 2 diabetes
Robert Sladek,Ghislain Rocheleau,Johan Rung,Christian Dina,Lishuang Shen,David Serre,Philippe Boutin,Daniel Vincent,Alexandre Belisle,Samy Hadjadj,Beverley Balkau,Barbara Heude,Guillaume Charpentier,Thomas J. Hudson,Thomas J. Hudson,Alexandre Montpetit,Alexey V. Pshezhetsky,Marc Prentki,Barry I. Posner,David J. Balding,David Meyre,Constantin Polychronakos,Philippe Froguel,Philippe Froguel +23 more
TL;DR: Four loci containing variants that confer type 2 diabetes risk are identified and constitute proof of principle for the genome-wide approach to the elucidation of complex genetic traits.
Journal ArticleDOI
Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia.
Johan Rung,Stéphane Cauchi,Anders Albrechtsen,Lishuang Shen,Lishuang Shen,Ghislain Rocheleau,Ghislain Rocheleau,Christine Cavalcanti-Proença,Francois Bacot,Beverley Balkau,Alexandre Belisle,Knut Borch-Johnsen,Guillaume Charpentier,Christian Dina,Emmanuelle Durand,Paul Elliott,Samy Hadjadj,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Jaana Laitinen,Torsten Lauritzen,Michel Marre,Alexander Mazur,David Meyre,Alexandre Montpetit,Charlotta Pisinger,Barry I. Posner,Pernille Poulsen,Anneli Pouta,Anneli Pouta,Marc Prentki,Rasmus Ribel-Madsen,Aimo Ruokonen,A. Sandbaek,David Serre,David Serre,Jean Tichet,Martine Vaxillaire,Jørgen F. P. Wojtaszewski,Allan Vaag,Allan Vaag,Torben Hansen,Torben Hansen,Constantin Polychronakos,Oluf Pedersen,Oluf Pedersen,Philippe Froguel,Philippe Froguel,Robert Sladek +48 more
TL;DR: The C allele of rs2943641 was associated with insulin resistance and hyperinsulinemia in 14,358 French, Danish and Finnish participants from population-based cohorts; this allele was also associated with reduced basal levels of IRS1 protein and decreased insulin induction of IRS 1-associated phosphatidylinositol-3-OH kinase activity in human skeletal muscle biopsies.
Journal ArticleDOI
Tools for mapping high-throughput sequencing data
TL;DR: This survey focuses on classifying mappers through a wide number of characteristics to allow practitioners to compare the mappers more easily and find those that are most suitable for their specific problem.
Journal ArticleDOI
The impact of low-frequency and rare variants on lipid levels.
Ida Surakka,Ida Surakka,Momoko Horikoshi,Reedik Mägi,Antti-Pekka Sarin,Antti-Pekka Sarin,Anubha Mahajan,Vasiliki Lagou,Letizia Marullo,Teresa Ferreira,Benjamin Miraglio,Sanna Timonen,Johannes Kettunen,Johannes Kettunen,Matti Pirinen,Juha Karjalainen,Gudmar Thorleifsson,Sara Hägg,Sara Hägg,Jouke-Jan Hottenga,A Isaacs,A Isaacs,A Isaacs,Claes Ladenvall,Marian Beekman,Tõnu Esko,Janina S. Ried,Christopher P. Nelson,Christina Willenborg,Stefan Gustafsson,Stefan Gustafsson,Harm-Jan Westra,Matthew Blades,Anton J. M. de Craen,Eco J. C. de Geus,Joris Deelen,Harald Grallert,Anders Hamsten,Aki S. Havulinna,Christian Hengstenberg,Jeanine J. Houwing-Duistermaat,Elina Hyppönen,Lennart C. Karssen,Terho Lehtimäki,Valeriya Lyssenko,Patrik K. E. Magnusson,Evelin Mihailov,Martina Müller-Nurasyid,John Patrick Mpindi,Nancy L. Pedersen,Brenda W.J.H. Penninx,Markus Perola,Tune H. Pers,Tune H. Pers,Annette Peters,Johan Rung,Johannes H. Smit,Valgerdur Steinthorsdottir,Martin D. Tobin,Natalia Tšernikova,Elisabeth M. van Leeuwen,Jorma Viikari,Sara M. Willems,Gonneke Willemsen,Heribert Schunkert,Jeanette Erdmann,Nilesh J. Samani,Jaakko Kaprio,Jaakko Kaprio,Lars Lind,Christian Gieger,Andres Metspalu,P. Eline Slagboom,Leif Groop,Cornelia M. van Duijn,Johan G. Eriksson,Antti Jula,Veikko Salomaa,Dorret I. Boomsma,Christine Power,Olli T. Raitakari,Erik Ingelsson,Erik Ingelsson,Marjo-Riitta Järvelin,Unnur Thorsteinsdottir,Lude Franke,Elina Ikonen,Olli Kallioniemi,Vilja Pietiäinen,Cecilia M. Lindgren,Cecilia M. Lindgren,Kari Stefansson,Aarno Palotie,Mark I. McCarthy,Andrew P. Morris,Andrew P. Morris,Andrew P. Morris,Inga Prokopenko,Samuli Ripatti +98 more
TL;DR: Using a genome-wide screen of 9.6 million genetic variants achieved through 1000 Genomes Project imputation in 62,166 samples, association to lipid traits in 93 loci is identified, including 79 previously identified loci with new lead SNPs and 10 new loci, including 15 locu with a low-frequency lead SNP and 10 loco with a missense lead SNP.
Journal ArticleDOI
A polymorphism within the G6PC2 gene is associated with fasting plasma glucose levels
Nabila Bouatia-Naji,Ghislain Rocheleau,Leentje Van Lommel,Katleen Lemaire,Frans Schuit,Christine Cavalcanti-Proença,Marion Marchand,Anna-Liisa Hartikainen,Ulla Sovio,Franck De Graeve,Johan Rung,Martine Vaxillaire,Jean Tichet,Michel Marre,Beverley Balkau,Jacques Weill,Paul Elliott,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,David Meyre,Constantin Polychronakos,Christian Dina,Robert Sladek,Philippe Froguel,Philippe Froguel +24 more
TL;DR: It is speculated that G6PC2 regulates FPG by modulating the set point for glucose-stimulated insulin secretion in pancreatic β cells, which is associated with type 2 diabetes risk.