F
Fangyi Gu
Researcher at National Institutes of Health
Publications - 42
Citations - 3662
Fangyi Gu is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Cancer & Lung cancer. The author has an hindex of 25, co-authored 40 publications receiving 3112 citations. Previous affiliations of Fangyi Gu include United States Department of Health and Human Services & Roswell Park Cancer Institute.
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Journal ArticleDOI
Genome-wide meta-analyses identify multiple loci associated with smoking behavior
Helena Furberg,Yunjung Kim,Jennifer Dackor,Eric Boerwinkle,Nora Franceschini,Diego Ardissino,Luisa Bernardinelli,Luisa Bernardinelli,Pier Mannuccio Mannucci,Francesco Mauri,Piera Angelica Merlini,Devin Absher,Themistocles L. Assimes,Stephen P. Fortmann,Carlos Iribarren,Joshua W. Knowles,Thomas Quertermous,Luigi Ferrucci,Toshiko Tanaka,Joshua C. Bis,Curt D. Furberg,Talin Haritunians,Barbara McKnight,Bruce M. Psaty,Bruce M. Psaty,Kent D. Taylor,Evan L. Thacker,Peter Almgren,Leif Groop,Claes Ladenvall,Michael Boehnke,Anne U. Jackson,Karen L. Mohlke,Heather M. Stringham,Jaakko Tuomilehto,Jaakko Tuomilehto,Emelia J. Benjamin,Shih-Jen Hwang,Daniel Levy,Sarah R. Preis,Ramachandran S. Vasan,Jubao Duan,Pablo V. Gejman,Douglas F. Levinson,Alan R. Sanders,Jianxin Shi,Esther H. Lips,James McKay,Antonio Agudo,Luigi Barzan,Vladimir Bencko,Simone Benhamou,Simone Benhamou,Xavier Castellsagué,Cristina Canova,David I. Conway,Eleonora Fabianova,Lenka Foretova,Vladimir Janout,Claire M. Healy,Ivana Holcatova,Kristina Kjærheim,Pagona Lagiou,Jolanta Lissowska,Ray Lowry,Tatiana V. Macfarlane,Dana Mates,Lorenzo Richiardi,Peter Rudnai,Neonilia Szeszenia-Dabrowska,David Zaridze,Ariana Znaor,Mark Lathrop,Paul Brennan,Stefania Bandinelli,Timothy M. Frayling,Jack M. Guralnik,Yuri Milaneschi,John R. B. Perry,David Altshuler,David Altshuler,Roberto Elosua,S. Kathiresan,S. Kathiresan,Gavin Lucas,Olle Melander,Christopher J. O'Donnell,Veikko Salomaa,Stephen M. Schwartz,Benjamin F. Voight,Brenda W.J.H. Penninx,Johannes H. Smit,Nicole Vogelzangs,Dorret I. Boomsma,Eco J. C. de Geus,Jacqueline M. Vink,Gonneke Willemsen,Stephen J. Chanock,Fangyi Gu,Susan E. Hankinson,David J. Hunter,Albert Hofman,Henning Tiemeier,André G. Uitterlinden,Cornelia M. van Duijn,Stefan Walter,Daniel I. Chasman,Brendan M. Everett,Guillaume Paré,Paul M. Ridker,Ming D. Li,Hermine H. Maes,Janet Audrain-McGovern,Danielle Posthuma,Laura M. Thornton,Caryn Lerman,Jaakko Kaprio,Jaakko Kaprio,Jed E. Rose,John P. A. Ioannidis,John P. A. Ioannidis,Peter Kraft,Danyu Lin,Patrick F. Sullivan +123 more
TL;DR: A meta-analyses of several smoking phenotypes within cohorts of the Tobacco and Genetics Consortium found the strongest association was a synonymous 15q25 SNP in the nicotinic receptor gene CHRNA3, and three loci associated with number of cigarettes smoked per day were identified.
Journal ArticleDOI
Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes
James D. McKay,Rayjean J. Hung,Younghun Han,Xuchen Zong,Robert Carreras-Torres,David C. Christiani,Neil E. Caporaso,Mattias Johansson,Xiangjun Xiao,Yafang Li,Jinyoung Byun,Alison M. Dunning,Karen A. Pooley,David C. Qian,Xuemei Ji,Geoffrey Liu,Maria Timofeeva,Stig E. Bojesen,Stig E. Bojesen,Stig E. Bojesen,Xifeng Wu,Loic Le Marchand,Demetrios Albanes,Heike Bickeböller,Melinda C. Aldrich,William S. Bush,Adonina Tardón,Gad Rennert,M. Dawn Teare,John K. Field,Lambertus A. Kiemeney,Philip Lazarus,Aage Haugen,Stephen Lam,Matthew B. Schabath,Angeline S. Andrew,Hongbing Shen,Yun Chul Hong,Jian-Min Yuan,Pier Alberto Bertazzi,Angela Cecilia Pesatori,Yuanqing Ye,Nancy Diao,Li Su,Ruyang Zhang,Yonathan Brhane,Natasha B. Leighl,Jakob S Johansen,Anders Mellemgaard,Walid Saliba,Christopher A. Haiman,Lynne R. Wilkens,Ana Fernández-Somoano,Guillermo Fernández-Tardón,Henricus F. M. van der Heijden,Jin Hee Kim,Juncheng Dai,Zhibin Hu,Michael P.A. Davies,Michael W. Marcus,Hans Brunnström,Jonas Manjer,Olle Melander,David C. Muller,Kim Overvad,Antonia Trichopoulou,Rosario Tumino,Jennifer A. Doherty,Matt P Barnett,Chu Chen,Gary E. Goodman,Angela Cox,Fiona Taylor,Penella J. Woll,Irene Brüske,H-Erich Wichmann,H-Erich Wichmann,Judith Manz,Thomas Muley,Angela Risch,Albert Rosenberger,Kjell Grankvist,Mikael Johansson,Frances A. Shepherd,Ming-Sound Tsao,Susanne M. Arnold,Eric B. Haura,Ciprian Bolca,Ivana Holcatova,Vladimir Janout,Milica Kontic,Jolanta Lissowska,Anush Mukeria,Simona Ognjanovic,Tadeusz M Orlowski,Ghislaine Scelo,Beata Swiatkowska,David Zaridze,Per Bakke,Vidar Skaug,Shanbeh Zienolddiny,Eric J. Duell,Lesley M. Butler,Woon-Puay Koh,Yu-Tang Gao,Richard S. Houlston,John McLaughlin,Victoria L. Stevens,Philippe Joubert,Maxime Lamontagne,David C. Nickle,Ma'en Obeidat,Wim Timens,Bin Zhu,Lei Song,Linda Kachuri,María Soler Artigas,María Soler Artigas,Martin D. Tobin,Martin D. Tobin,Louise V. Wain,Louise V. Wain,Thorunn Rafnar,Thorgeir E. Thorgeirsson,Gunnar W Reginsson,Kari Stefansson,Dana B. Hancock,Laura J. Bierut,Margaret R. Spitz,Nathan C. Gaddis,Sharon M. Lutz,Fangyi Gu,Eric O. Johnson,Ahsan Kamal,Claudio W. Pikielny,Dakai Zhu,Sara Lindstroem,Xia Jiang,Rachel F. Tyndale,Rachel F. Tyndale,Georgia Chenevix-Trench,Jonathan Beesley,Yohan Bossé,Stephen J. Chanock,Paul Brennan,Maria Teresa Landi,Christopher I. Amos +146 more
TL;DR: 18 susceptibility loci achieving genome-wide significance are identified, including 10 new loci linked with lung cancer overall and six loci associated with lung adenocarcinoma, highlighting the striking heterogeneity in genetic susceptibility across the histological subtypes of lung cancer.
Journal ArticleDOI
Genome-Wide and Candidate Gene Association Study of Cigarette Smoking Behaviors
Neil E. Caporaso,Fangyi Gu,Nilanjan Chatterjee,Jin Sheng-Chih,Kai Yu,Meredith Yeager,Constance Chen,Kevin B. Jacobs,William Wheeler,Maria Teresa Landi,Regina G. Ziegler,David J. Hunter,David J. Hunter,Stephen Chanock,Susan E. Hankinson,Peter Kraft,Andrew W. Bergen +16 more
TL;DR: The contribution of common genetic variation to one or more established smoking behaviors was investigated in a joint analysis of two genome wide association studies (GWAS) performed as part of the Cancer Genetic Markers of Susceptibility project.
Journal ArticleDOI
Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption.
Marilyn C. Cornelis,Enda M. Byrne,Tõnu Esko,Mike A. Nalls,Andrea Ganna,Nina P. Paynter,Keri L. Monda,Najaf Amin,Krista Fischer,Frida Renström,Julius S. Ngwa,Ville Huikari,Alana Cavadino,Ilja M. Nolte,Alexander Teumer,K. Yu,Pedro Marques-Vidal,Rajesh Rawal,Ani Manichaikul,Mary K. Wojczynski,Jacqueline M. Vink,Jing Hua Zhao,George Burlutsky,Jari Lahti,Vera Mikkilä,Rozenn N. Lemaitre,Joel Eriksson,Solomon K. Musani,Toshiko Tanaka,Frank Geller,Jian'an Luan,Jennie Hui,Reedik Mägi,Maria Dimitriou,Melissa E. Garcia,Weang Kee Ho,Margaret J. Wright,Lynda M. Rose,Patrik K. E. Magnusson,Nancy L. Pedersen,David Couper,Ben A. Oostra,Albert Hofman,M. A. Ikram,Henning Tiemeier,A.G. Uitterlinden,F. J.A. Van Rooij,Inês Barroso,Ingegerd Johansson,Luting Xue,Marika Kaakinen,Lili Milani,Chris Power,Harold Snieder,Ronald P. Stolk,Sebastian E. Baumeister,Reiner Biffar,Fangyi Gu,François Bastardot,Zoltán Kutalik,David R. Jacobs,Nita G. Forouhi,Evelin Mihailov,Lars Lind,Cecilia M. Lindgren,Karl Michaëlsson,Andrew P. Morris,Majken K. Jensen,Kay-Tee Khaw,Robert Luben,Jie Jin Wang,Satu Männistö,Mia-Maria Perälä,Mika Kähönen,Terho Lehtimäki,Jorma Viikari,Dariush Mozaffarian,Kenneth J. Mukamal,Bruce M. Psaty,Angela Döring,A. C. Heath,Grant W. Montgomery,Norbert Dahmen,T. Carithers,Katherine L. Tucker,Luigi Ferrucci,Heather A. Boyd,Mads Melbye,Jorien L. Treur,Dan Mellström,Jouke-Jan Hottenga,Inga Prokopenko,Anke Tönjes,Panos Deloukas,Stavroula Kanoni,Mattias Lorentzon,Denise K. Houston,Yongmei Liu,John Danesh,Adil Rasheed,Marc A. Mason,Alan B. Zonderman,Lude Franke,Bruce S. Kristal,Juha Karjalainen,Danielle R. Reed,Harm-Jan Westra,Michele K. Evans,Danish Saleheen,T.B. Harris,George Dedoussis,Gary C. Curhan,Michael Stumvoll,John Beilby,Louis R. Pasquale,Bjarke Feenstra,Stefania Bandinelli,Jose M. Ordovas,Andrew T. Chan,Ulrike Peters,Claes Ohlsson,Christian Gieger,Nicholas G. Martin,M. Waldenberger,David S. Siscovick,Olli T. Raitakari,Johan G. Eriksson,Paul Mitchell,David J. Hunter,P. Kraft,Eric B. Rimm,Dorret I. Boomsma,Ingrid B. Borecki,Ruth J. F. Loos,Nicholas J. Wareham,Peter Vollenweider,Neil E. Caporaso,Hans-Jörgen Grabe,Marian L. Neuhouser,Bruce H. R. Wolffenbuttel,Frank B. Hu,Elina Hyppönen,Marjo-Riitta Järvelin,L. A. Cupples,Paul W. Franks,Paul M. Ridker,C M van Duijn,Gerardo Heiss,Andres Metspalu,Kari E. North,Erik Ingelsson,Jennifer A. Nettleton,R. M. van Dam,Daniel I. Chasman +153 more
TL;DR: In this article, the authors conducted a genome-wide meta-analysis of predominately regular-type coffee consumption (cups per day) among up to 91,462 coffee consumers of European ancestry with top single-nucleotide polymorphisms (SNPs) followed-up in ~30,062 and 7964 coffee consumers with European and African-American ancestry, respectively.
Journal ArticleDOI
Identifying biomarkers of dietary patterns by using metabolomics.
Mary C. Playdon,Steven C. Moore,Andriy Derkach,Jill Reedy,Amy F. Subar,Joshua N. Sampson,Demetrius Albanes,Fangyi Gu,Jukka Kontto,Camille Lassale,Linda M. Liao,Satu Männistö,Alison M. Mondul,Stephanie J. Weinstein,Melinda L. Irwin,Melinda L. Irwin,Susan T. Mayne,Susan T. Mayne,Rachael Z. Stolzenberg-Solomon +18 more
TL;DR: Diet quality, measured by healthy diet indexes, is associated with serum metabolites, with the specific metabolite profile of each diet index related to the diet components used to score adherence.