The MIntAct project--IntAct as a common curation platform for 11 molecular interaction databases.
Sandra Orchard,Mais G. Ammari,Bruno Aranda,Lionel Breuza,Leonardo Briganti,Fiona Broackes-Carter,Nancy H. Campbell,Gayatri Chavali,Carol Chen,Noemi del-Toro,Margaret Duesbury,Marine Dumousseau,Eugenia Galeota,Ursula Hinz,Marta Iannuccelli,Sruthi Jagannathan,Rafael C. Jimenez,Jyoti Khadake,Astrid Lagreid,Luana Licata,Ruth C. Lovering,Birgit H M Meldal,Anna N. Melidoni,Mila Milagros,Daniele Peluso,Livia Perfetto,Pablo Porras,Arathi Raghunath,Sylvie Ricard-Blum,Bernd Roechert,Andre Stutz,Michael Tognolli,Kim Van Roey,Gianni Cesareni,Henning Hermjakob +34 more
TLDR
All data manually curated by the MINT curators have been moved into the IntAct database at EMBL-EBI and are merged with the existing IntAct dataset.Abstract:
IntAct (freely available at http://www.ebi.ac.uk/intact) is an open-source, open data molecular interaction database populated by data either curated from the literature or from direct data depositions. IntAct has developed a sophisticated web-based curation tool, capable of supporting both IMEx- and MIMIx-level curation. This tool is now utilized by multiple additional curation teams, all of whom annotate data directly into the IntAct database. Members of the IntAct team supply appropriate levels of training, perform quality control on entries and take responsibility for long-term data maintenance. Recently, the MINT and IntAct databases decided to merge their separate efforts to make optimal use of limited developer resources and maximize the curation output. All data manually curated by the MINT curators have been moved into the IntAct database at EMBL-EBI and are merged with the existing IntAct dataset. Both IntAct and MINT are active contributors to the IMEx consortium (http://www.imexconsortium.org).read more
Citations
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STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets.
Damian Szklarczyk,Annika L. Gable,David Lyon,Alexander Junge,Stefan Wyder,Jaime Huerta-Cepas,Milan Simonovic,Nadezhda Tsankova Doncheva,John H. Morris,Peer Bork,Lars Juhl Jensen,Christian von Mering +11 more
TL;DR: The latest version of STRING more than doubles the number of organisms it covers, and offers an option to upload entire, genome-wide datasets as input, allowing users to visualize subsets as interaction networks and to perform gene-set enrichment analysis on the entire input.
Journal ArticleDOI
STRING v10: protein–protein interaction networks, integrated over the tree of life
Damian Szklarczyk,Andrea Franceschini,Stefan Wyder,Kristoffer Forslund,Davide Heller,Jaime Huerta-Cepas,Milan Simonovic,Alexander Roth,Alberto Santos,Kalliopi Tsafou,Michael Kuhn,Peer Bork,Lars Juhl Jensen,Christian von Mering +13 more
TL;DR: H hierarchical and self-consistent orthology annotations are introduced for all interacting proteins, grouping the proteins into families at various levels of phylogenetic resolution in the STRING database.
Journal ArticleDOI
The STRING database in 2017: quality-controlled protein-protein association networks, made broadly accessible.
Damian Szklarczyk,John H. Morris,Helen Cook,Michael Kuhn,Stefan Wyder,Milan Simonovic,Alberto Santos,Nadezhda Tsankova Doncheva,Alexander Roth,Peer Bork,Lars Juhl Jensen,Christian von Mering +11 more
TL;DR: In the latest version 10.5 of STRING, the biggest changes are concerned with data dissemination: the web frontend has been completely redesigned to reduce dependency on outdated browser technologies, and the database can now also be queried from inside the popular Cytoscape software framework.
Journal ArticleDOI
CellPhoneDB: inferring cell-cell communication from combined expression of multi-subunit ligand-receptor complexes.
TL;DR: The structure and content of CellPhoneDB is outlined, procedures for inferring cell–cell communication networks from single-cell RNA sequencing data are provided and a practical step-by-step guide to help implement the protocol is presented.
Journal ArticleDOI
The InterPro protein families database: the classification resource after 15 years
Alex L. Mitchell,Hsin-Yu Chang,Louise C. Daugherty,Matthew Fraser,Sarah Hunter,Rodrigo Lopez,Craig McAnulla,Conor McMenamin,Gift Nuka,Sebastien Pesseat,Amaia Sangrador-Vegas,Maxim Scheremetjew,Claudia Rato,Siew-Yit Yong,Alex Bateman,Marco Punta,Teresa K. Attwood,Christian J. A. Sigrist,Nicole Redaschi,Catherine Rivoire,Ioannis Xenarios,Daniel Kahn,Dominique Guyot,Peer Bork,Ivica Letunic,Julian Gough,Matt E. Oates,Daniel H. Haft,Hongzhan Huang,Darren A. Natale,Cathy H. Wu,Christine A. Orengo,Ian Sillitoe,Huaiyu Mi,Paul Thomas,Robert D. Finn +35 more
TL;DR: The new domain architecture search tool is described and the process of mapping of Gene Ontology terms to InterPro is outlined, and the challenges faced by the resource given the explosive growth in sequence data in recent years are discussed.
References
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Journal ArticleDOI
The IntAct molecular interaction database in 2012
Samuel Kerrien,Bruno Aranda,Lionel Breuza,Alan Bridge,Fiona Broackes-Carter,Carol Chen,Margaret Duesbury,Marine Dumousseau,M Feuermann,Ursula Hinz,Christine Jandrasits,Rafael C. Jimenez,Jyoti Khadake,Usha Mahadevan,Patrick Masson,Ivo Pedruzzi,Eric Pfeiffenberger,Pablo Porras,Arathi Raghunath,Bernd Roechert,Sandra Orchard,Henning Hermjakob +21 more
TL;DR: Two levels of curation are now available within the IntAct database, with both IMEx-level annotation and less detailed MIMIx-compatible entries currently supported.
Journal ArticleDOI
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Rintaro Saito,Michael E. Smoot,Keiichiro Ono,Johannes Ruscheinski,Peng-Liang Wang,Samad Lotia,Alexander R. Pico,Gary D. Bader,Trey Ideker +8 more
TL;DR: A travel guide to the world of plugins, covering the 152 publicly available plugins for Cytoscape 2.5–2.8 and ongoing efforts to distribute, organize and maintain the quality of the collection.
Journal ArticleDOI
MINT, the molecular interaction database: 2012 update
Luana Licata,Leonardo Briganti,Daniele Peluso,Livia Perfetto,Marta Iannuccelli,Eugenia Galeota,Francesca Sacco,A. Palma,Aurelio Pio Nardozza,Elena Santonico,Luisa Castagnoli,Gianni Cesareni +11 more
TL;DR: The growth of the database, the major changes in curation policy and a new algorithm to assign a confidence to each interaction are reported here.
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