K
Kenneth P. Nephew
Researcher at Indiana University
Publications - 284
Citations - 17018
Kenneth P. Nephew is an academic researcher from Indiana University. The author has contributed to research in topics: Ovarian cancer & DNA methylation. The author has an hindex of 66, co-authored 267 publications receiving 15106 citations. Previous affiliations of Kenneth P. Nephew include University of Tennessee Health Science Center & Indiana University – Purdue University Indianapolis.
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Journal ArticleDOI
Identification and characterization of ovarian cancer-initiating cells from primary human tumors.
Shu Zhang,Curt Balch,Michael W.Y. Chan,Hung Cheng Lai,Daniela Matei,Jeanne M. Schilder,Pearlly S. Yan,Tim H M Huang,Kenneth P. Nephew +8 more
TL;DR: It is asserted that epithelial ovarian cancers derive from a subpopulation of CD44(+)CD117(+) cells, thus representing a possible therapeutic target for this devastating disease.
Journal ArticleDOI
Rethinking ovarian cancer: recommendations for improving outcomes
Sebastian Vaughan,Jermaine Coward,Robert C. Bast,Andrew Berchuck,Jonathan S. Berek,James D. Brenton,George Coukos,Christopher C. Crum,Ronny Drapkin,Dariush Etemadmoghadam,Michael Friedlander,Hani Gabra,Stan B. Kaye,Christopher J. Lord,Ernst Lengyel,Douglas A. Levine,Iain A. McNeish,Usha Menon,Gordon B. Mills,Kenneth P. Nephew,Amit M. Oza,Anil K. Sood,Euan A. Stronach,Henning Walczak,David D.L. Bowtell,Frances R. Balkwill +25 more
TL;DR: Nine major recommendations that should be taken to improve the outcome for women with ovarian cancer are outlined in this Opinion article.
Journal ArticleDOI
Rethinking ovarian cancer II: Reducing mortality from high-grade serous ovarian cancer
David D.L. Bowtell,David D.L. Bowtell,Steffen Böhm,Ahmed Ashour Ahmed,Paul Joseph Aspuria,Robert C. Bast,Valerie Beral,Jonathan S. Berek,Michael J. Birrer,Sarah P. Blagden,Michael A. Bookman,James D. Brenton,Katherine B. Chiappinelli,Filipe C. Martins,George Coukos,Ronny Drapkin,Richard J. Edmondson,Christina Fotopoulou,Hani Gabra,Jérôme Galon,Charlie Gourley,Valerie Heong,David G. Huntsman,Marcin P. Iwanicki,Beth Y. Karlan,Allyson Kaye,Ernst Lengyel,Douglas A. Levine,Karen H. Lu,Iain A. McNeish,Usha Menon,Steven A. Narod,Brad H. Nelson,Kenneth P. Nephew,Paul D.P. Pharoah,Daniel J. Powell,Pilar Ramos,Iris L. Romero,Clare L. Scott,Anil K. Sood,Euan A. Stronach,Frances R. Balkwill +41 more
TL;DR: This 'roadmap' for HGSOC was determined after extensive discussions at an Ovarian Cancer Action meeting in January 2015 and aims to reduce incidence and improve outcomes for women with this disease.
Journal ArticleDOI
EGFR and MET receptor tyrosine kinase-altered microRNA expression induces tumorigenesis and gefitinib resistance in lung cancers
Michela Garofalo,Giulia Romano,Gianpiero Di Leva,Gerard J. Nuovo,Young-Jun Jeon,Apollinaire Ngankeu,Jin Sun,Francesca Lovat,Hansjuerg Alder,Gerolama Condorelli,Jeffrey A. Engelman,Mayumi Ono,Jin Kyung Rho,Luciano Cascione,Luciano Cascione,Stefano Volinia,Kenneth P. Nephew,Carlo M. Croce +17 more
TL;DR: Modulation of specific microRNAs may provide a therapeutic approach for future treatment of NSCLC by inhibiting the expression of Bim, APAF-1, PKC-ε and SRC genes.
Journal ArticleDOI
Epigenetic Resensitization to Platinum in Ovarian Cancer
Daniela Matei,Fang Fang,Changyu Shen,Jeanne M. Schilder,Alesha Arnold,Yan Zeng,William A. Berry,Tim H M Huang,Kenneth P. Nephew,Kenneth P. Nephew +9 more
TL;DR: The results of this study suggest that low-dose decitabine altered DNA methylation of genes and cancer pathways, restoring sensitivity to carboplatin in patients with heavily pretreated ovarian cancer and resulting in a high RR and prolonged PFS.