K
Kim Boekelheide
Researcher at Brown University
Publications - 201
Citations - 12333
Kim Boekelheide is an academic researcher from Brown University. The author has contributed to research in topics: Sertoli cell & Germ cell. The author has an hindex of 56, co-authored 200 publications receiving 11531 citations. Previous affiliations of Kim Boekelheide include Duke University & Butler Hospital.
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Journal ArticleDOI
Toxicity testing in the 21st century: a vision and a strategy
Daniel Krewski,Daniel Acosta,Melvin E. Andersen,Henry A. Anderson,John C. Bailar,Kim Boekelheide,Robert L. Brent,Gail Charnley,Vivian G. Cheung,Sidney Green,Karl T. Kelsey,Nancy I. Kerkvliet,Abby A. Li,Lawrence E. McCray,Otto A. Meyer,Reid D. Patterson,William D. Pennie,Robert A. Scala,Gina Solomon,Martin L. Stephens,James D. Yager,Lauren Zeise +21 more
TL;DR: Implementation of a new toxicity testing paradigm firmly based on human biology by transitioning from current expensive and lengthy in vivo testing with qualitative endpoints to in vitro toxicity pathway assays on human cells or cell lines using robotic high-throughput screening with mechanistic quantitative parameters.
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NTP Center for the Evaluation of Risks to Human Reproduction: phthalates expert panel report on the reproductive and developmental toxicity of di-n-butyl phthalate ☆
Robert J. Kavlock,Kim Boekelheide,Robert E. Chapin,Michael L. Cunningham,Elaine M. Faustman,Paul M. D. Foster,Mari S. Golub,Rogene F. Henderson,Irwin Hinberg,Ruth Little,Jennifer Seed,Katherine M. Shea,Sonia Tabacova,Rochelle W. Tyl,Paige L. Williams,Timothy R. Zacharewski +15 more
TL;DR: This poster presents a probabilistic procedure to evaluate the phytochemical properties of anthrax, and the results have shown to be safe and beneficial for human health and the environment.
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The Mammalian SIR2α Protein Has a Role in Embryogenesis and Gametogenesis
Michael W. McBurney,Xiaofeng Yang,Karen Jardine,Mary L. Hixon,Kim Boekelheide,John R. Webb,Peter M. Lansdorp,Madeleine E. Lemieux +7 more
TL;DR: No evidence for failure of gene silencing is found in sir2α null animals, suggesting that either SIR2α has a different role in mammals than it does in Saccharomyces cerevisiae or that its role in genesilencing in confined to a small subset of mammalian genes.
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NTP‐CERHR expert panel report on the reproductive and developmental toxicity of bisphenol A
Robert E. Chapin,Jane Adams,Kim Boekelheide,L. Earl Gray,Simon W. Hayward,Peter S.J. Lees,Barry S. McIntyre,Kenneth M. Portier,Teresa M. Schnorr,Sherry G. Selevan,John G. Vandenbergh,Susan Woskie +11 more
TL;DR: This research presents a meta-analyses of the immune system’s response to exposure to radiation and shows clear patterns of decline in the immune systems of men and women aged 65 and over.
Journal ArticleDOI
The fas system is a key regulator of germ cell apoptosis in the testis
TL;DR: In this model, FasL expressed by Sertoli cells initiates the apoptotic death of germ cells expressing Fas, which is proposed as a key regulator of spermatogenesis.