K
Klaus Pantel
Researcher at University of Hamburg
Publications - 566
Citations - 36666
Klaus Pantel is an academic researcher from University of Hamburg. The author has contributed to research in topics: Circulating tumor cell & Cancer. The author has an hindex of 90, co-authored 486 publications receiving 29848 citations.
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Journal ArticleDOI
Tumour exosome integrins determine organotropic metastasis
Ayuko Hoshino,Bruno Costa-Silva,Tang-Long Shen,Gonçalo Rodrigues,Ayako Hashimoto,Milica Tesic Mark,Henrik Molina,Shinji Kohsaka,Angela Di Giannatale,Sophia Ceder,Swarnima Singh,Caitlin Williams,Nadine Soplop,Kunihiro Uryu,Lindsay A. Pharmer,Tari A. King,Linda Bojmar,Alexander E. Davies,Yonathan Ararso,Tuo Zhang,Haiying Zhang,Jonathan M. Hernandez,Joshua Mitchell Weiss,Vanessa D. Dumont-Cole,Kimberly Kramer,Leonard H. Wexler,Aru Narendran,Gary K. Schwartz,John H. Healey,Per Sandström,Knut Jørgen Labori,Elin H. Kure,Paul M. Grandgenett,Michael A. Hollingsworth,Maria de Sousa,Sukwinder Kaur,Maneesh Jain,Kavita Mallya,Surinder K. Batra,William R. Jarnagin,Mary S. Brady,Øystein Fodstad,Volkmar Müller,Klaus Pantel,Andy J. Minn,Mina J. Bissell,Benjamin A. Garcia,Yibin Kang,Yibin Kang,Vinagolu K. Rajasekhar,Cyrus M. Ghajar,Irina Matei,Héctor Peinado,Jacqueline Bromberg,Jacqueline Bromberg,David Lyden +55 more
TL;DR: It is demonstrated that exosomes from mouse and human lung-, liver- and brain-tropic tumour cells fuse preferentially with resident cells at their predicted destination, namely lung fibroblasts and epithelial cells, liver Kupffer cells and brain endothelial cells.
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PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis
Valerie S. LeBleu,Joyce T. O’Connell,Karina N. Gonzalez Herrera,Harriet Wikman,Klaus Pantel,Marcia C. Haigis,Fernanda Machado de Carvalho,Aline Santos Damascena,Ludmilla Thomé Domingos Chinen,Rafael Malagoli Rocha,John M. Asara,Raghu Kalluri +11 more
TL;DR: It is reported that migratory/invasive cancer cells specifically favour mitochondrial respiration and increased ATP production, and mitochondrial biogenesis and respiration induced by PGC-1α are also essential for functional motility of cancer cells and metastasis.
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Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay
Irène Baccelli,Andreas Schneeweiss,Sabine Riethdorf,Albrecht Stenzinger,Anja Schillert,Vanessa Vogel,Vanessa Vogel,Corinna Klein,Massimo Saini,Tobias Bäuerle,Markus Wallwiener,Tim Holland-Letz,Thomas Höfner,Martin R. Sprick,Martina Scharpff,Frederik Marmé,Hans-Peter Sinn,Klaus Pantel,Wilko Weichert,Andreas Trumpp +19 more
TL;DR: It is shown that primary human luminal breast cancer CTCs contain MICs that give rise to bone, lung and liver metastases in mice, and functional circulating MICs and associated markers are described to aid the design of better tools to diagnose and treat metastatic breast cancer.
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Clinical relevance of circulating cell-free microRNAs in cancer
TL;DR: The latest developments in the use of circulating microRNAs as prognostic and predictive biomarkers are considered and their utility in personalized medicine is discussed.
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Tumor metastasis: moving new biological insights into the clinic
TL;DR: The explosive growth of metastasis research in the past decade has yielded an unprecedented wealth of information, but integration of such new knowledge into an improved, metastasis-oriented oncological drug development strategy is needed to thwart the development of metastatic disease at every stage of progression.