Klaus Pantel

TL;DR: It is demonstrated that exosomes from mouse and human lung-, liver- and brain-tropic tumour cells fuse preferentially with resident cells at their predicted destination, namely lung fibroblasts and epithelial cells, liver Kupffer cells and brain endothelial cells.

TL;DR: It is reported that migratory/invasive cancer cells specifically favour mitochondrial respiration and increased ATP production, and mitochondrial biogenesis and respiration induced by PGC-1α are also essential for functional motility of cancer cells and metastasis.

TL;DR: It is shown that primary human luminal breast cancer CTCs contain MICs that give rise to bone, lung and liver metastases in mice, and functional circulating MICs and associated markers are described to aid the design of better tools to diagnose and treat metastatic breast cancer.

TL;DR: The latest developments in the use of circulating microRNAs as prognostic and predictive biomarkers are considered and their utility in personalized medicine is discussed.

TL;DR: The explosive growth of metastasis research in the past decade has yielded an unprecedented wealth of information, but integration of such new knowledge into an improved, metastasis-oriented oncological drug development strategy is needed to thwart the development of metastatic disease at every stage of progression.