Lindsay P. Cameron

TL;DR: It is reported that, like ketamine, serotonergic psychedelics are capable of robustly increasing neuritogenesis and/or spinogenesis both in vitro and in vivo.

TL;DR: This work demonstrates that, through careful chemical design, it is possible to modify a psychedelic compound to produce a safer, non-hallucinogenic variant that has therapeutic potential.

TL;DR: iSeroSnFR can be used to detect serotonin release in freely behaving mice during fear conditioning, social interaction, and sleep/wake transitions, and it is expected that both machine-learning-guided binding-pocket redesign and iSero SnFR will have broad utility for the development of other sensors and in vitro and in-vivo serotonin detection, respectively.

TL;DR: It is found that while DMT elicits initial anxiogenic responses in several of these paradigms, its long-lasting effects tend to reduce anxiety by facilitating the extinction of cued fear memory, and DMT reduces immobility in the forced swim test, which is a characteristic behavioral response induced by many antidepressants.

TL;DR: It is found that chronic, intermittent, low doses of DMT produced an antidepressant-like phenotype and enhanced fear extinction learning without impacting working memory or social interaction.