L
Lorena Pantano
Researcher at Harvard University
Publications - 49
Citations - 4719
Lorena Pantano is an academic researcher from Harvard University. The author has contributed to research in topics: Small RNA & microRNA. The author has an hindex of 21, co-authored 46 publications receiving 3620 citations. Previous affiliations of Lorena Pantano include Pompeu Fabra University & Catalan Institution for Research and Advanced Studies.
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Journal ArticleDOI
Genomic analyses identify molecular subtypes of pancreatic cancer
Peter Bailey,David K. Chang,Katia Nones,Katia Nones,Amber L. Johns,Ann-Marie Patch,Ann-Marie Patch,Marie-Claude Gingras,David Miller,David Miller,Angelika N. Christ,Timothy J. C. Bruxner,Michael C.J. Quinn,Michael C.J. Quinn,Craig Nourse,Craig Nourse,Murtaugh Lc,Ivon Harliwong,Senel Idrisoglu,Suzanne Manning,Ehsan Nourbakhsh,Shivangi Wani,Shivangi Wani,J. Lynn Fink,Oliver Holmes,Oliver Holmes,Chin,Matthew J. Anderson,Stephen H. Kazakoff,Stephen H. Kazakoff,Conrad Leonard,Conrad Leonard,Felicity Newell,Nicola Waddell,Scott Wood,Scott Wood,Qinying Xu,Qinying Xu,Peter J. Wilson,Nicole Cloonan,Nicole Cloonan,Karin S. Kassahn,Karin S. Kassahn,Karin S. Kassahn,Darrin Taylor,Kelly Quek,Alan J. Robertson,Lorena Pantano,Laura Mincarelli,Luis Navarro Sanchez,Lisa Evers,Jianmin Wu,Mark Pinese,Mark J. Cowley,Jones,Jones,Emily K. Colvin,Adnan Nagrial,Emily S. Humphrey,Lorraine A. Chantrill,Lorraine A. Chantrill,Amanda Mawson,Jeremy L. Humphris,Angela Chou,Angela Chou,Marina Pajic,Marina Pajic,Christopher J. Scarlett,Christopher J. Scarlett,Andreia V. Pinho,Marc Giry-Laterriere,Ilse Rooman,Jaswinder S. Samra,James G. Kench,James G. Kench,James G. Kench,Jessica A. Lovell,Neil D. Merrett,Christopher W. Toon,Krishna Epari,Nam Q. Nguyen,Andrew Barbour,Nikolajs Zeps,Kim Moran-Jones,Nigel B. Jamieson,Janet Graham,Janet Graham,Fraser Duthie,Karin A. Oien,Karin A. Oien,Hair J,Robert Grützmann,Anirban Maitra,Christine A. Iacobuzio-Donahue,Christopher L. Wolfgang,Richard A. Morgan,Rita T. Lawlor,Corbo,Claudio Bassi,Borislav Rusev,Paola Capelli,Roberto Salvia,Giampaolo Tortora,Debabrata Mukhopadhyay,Gloria M. Petersen,Munzy Dm,William E. Fisher,Saadia A. Karim,Eshleman,Ralph H. Hruban,Christian Pilarsky,Jennifer P. Morton,Owen J. Sansom,Aldo Scarpa,Elizabeth A. Musgrove,Ulla-Maja Bailey,Oliver Hofmann,Oliver Hofmann,R. L. Sutherland,David A. Wheeler,Anthony J. Gill,Anthony J. Gill,Richard A. Gibbs,John V. Pearson,John V. Pearson,Andrew V. Biankin,Sean M. Grimmond,Sean M. Grimmond,Sean M. Grimmond +128 more
TL;DR: Detailed genomic analysis of 456 pancreatic ductal adenocarcinomas identified 32 recurrently mutated genes that aggregate into 10 pathways: KRAS, TGF-β, WNT, NOTCH, ROBO/SLIT signalling, G1/S transition, SWI-SNF, chromatin modification, DNA repair and RNA processing.
Journal ArticleDOI
Paternal Diet Defines Offspring Chromatin State and Intergenerational Obesity
Anita Öst,Anita Öst,Adelheid Lempradl,Eduard Casas,Melanie Weigert,Theodor Tiko,Merdin Deniz,Lorena Pantano,Ulrike Boenisch,Pavel M. Itskov,Marlon Stoeckius,Marius Ruf,Nikolaus Rajewsky,Gunter Reuter,Nicola Iovino,Carlos Ribeiro,Mattias Alenius,Steffen Heyne,Tanya Vavouri,J. Andrew Pospisilik +19 more
TL;DR: A Drosophila model of paternal-diet-induced intergenerational metabolic reprogramming (IGMR) is presented and evidence that a similar system may regulate obesity susceptibility and phenotype variation in mice and humans is found.
Journal ArticleDOI
A myriad of miRNA variants in control and Huntington’s disease brain regions detected by massively parallel sequencing
Eulàlia Martí,Lorena Pantano,Mónica Bañez-Coronel,Franc Llorens,Elena Miñones-Moyano,Sílvia Porta,Lauro Sumoy,Isidre Ferrer,Xavier Estivill +8 more
TL;DR: The results show that miRNA variability is a ubiquitous phenomenon in the adult human brain, which may influence gene expression in physiological and pathological conditions.
Journal ArticleDOI
SeqBuster, a bioinformatic tool for the processing and analysis of small RNAs datasets, reveals ubiquitous miRNA modifications in human embryonic cells.
TL;DR: The application of SeqBuster to small-RNA datasets of human embryonic stem cells revealed that most miRNAs present different types of isomiRs, some of them being associated to stem cell differentiation.
Journal ArticleDOI
Genome assembly comparison identifies structural variants in the human genome.
Razi Khaja,Junjun Zhang,Jeffrey R. MacDonald,Yongshu He,Ann M. Joseph-George,John Wei,Muhammad Rafiq,Muhammad Rafiq,Cheng Qian,Mary Shago,Lorena Pantano,Hiroyuki Aburatani,Keith W. Jones,Richard Redon,Matthew E. Hurles,Lluís Armengol,Xavier Estivill,Xavier Estivill,Richard J. Mural,Charles Lee,Stephen W. Scherer,Lars Feuk +21 more
TL;DR: Through comparison of two human assemblies, genome assembly comparison is shown to be a robust approach for identification of all classes of genetic variation, highlighting the need for comprehensive annotation strategies to fully interpret genome scanning and personalized sequencing projects.