Mary E. Soules

TL;DR: An overview of the imaging procedures of the ABCD study is provided, the basis for their selection and preliminary quality assurance and results that provide evidence for the feasibility and age-appropriateness of procedures and generalizability of findings to the existent literature are provided.

TL;DR: It is demonstrated that NOTCH pathway blockade depletes stem‐like cells in GBMs, suggesting that GSIs may be useful as chemotherapeutic reagents to target CSCs in malignant gliomas.

TL;DR: The baseline neuroimaging processing and subject-level analysis methods used by the Adolescent Brain Cognitive Development Study are described to be a resource of unprecedented scale and depth for studying typical and atypical development.

TL;DR: The baseline neuroimaging processing and subject-level analysis methods used by the ABCD DAIC in the centralized processing and extraction of neuroanatomical and functional imaging phenotypes are described.

TL;DR: Mild oxidative stress in dorsal root ganglion neurons leads to the activation of the transcription factor Nrf2 and expression of antioxidant (phase II) enzymes, and DRG neurons are protected from subsequent hyperglycemia-induced injury, as determined by activation of caspase 3 and the TUNEL assay.