Michael B. Sporn

TL;DR: Two metabolites produced in a cell-free liver incubation reaction also migrate on a high-pressure liquid chromatography column together with metabolites isolated from a tracheal organ culture system both in ultraviolet absorption and mass spectral characteristics and in migration rates on two different reverse-phase high- pressure liquid chromatographic systems.

TL;DR: Since the TGF-beta s have activity in promoting or inhibiting proliferation and differentiation of multiple cell types, it seems likely that the differential and tissue-specific transcriptional regulation of these genes is of fundamental importance in the induction and maintenance of differentiated cell types in various tissues.

TL;DR: It is illustrated here that sulfiredoxin can be rapidly induced in vivo by administration of CDDO-TFEA, a synthetic triterpenoid inducer of endogenous Nrf2, which may offer a way of reversing peroxiredoxin hyperoxidation in vivo following chronic or acute oxidative stress.

TL;DR: The results show for the first time the widespread regulation of TGF beta expression by retinoic acid in vivo, and suggest a possible mechanism by which retinoics regulate the functions of both normal and pre-neoplastic epithelia.

TL;DR: It has been shown that retinoids can exert effects on certain fully transformed, invasive, neoplastic cells, leading in certain instances to a suppression of proliferation and in other instances to terminal differentiation of these cells, resulting in a more benign, nonneoplastic pheno type.