M
Michael B. Sporn
Researcher at Dartmouth College
Publications - 561
Citations - 96644
Michael B. Sporn is an academic researcher from Dartmouth College. The author has contributed to research in topics: Transforming growth factor & Transforming growth factor beta. The author has an hindex of 157, co-authored 559 publications receiving 94605 citations. Previous affiliations of Michael B. Sporn include Cornell University & Reata Pharmaceuticals.
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The early history of TGF-β, and a brief glimpse of its future
TL;DR: This brief review is a retrospective on the original discovery of TGF-b, and the development of the field of T GF-b research in its earliest years, before 1990, to suggest a new explanation for the mechanism whereby a polypeptide growth factor might cause the malignant transformation of cells.
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Transcriptional Control of Expression of the TGF‐βs
Anita B. Roberts,Seong-Jin Kim,Paturu Kondaiah,Sonia B. Jakowlew,Fabienne Denhez,Adam B. Glick,Andrew G. Geiser,Shinichi Watanabe,Takafumi Noma,Robert J. Lechleider,Michael B. Sporn +10 more
TL;DR: This review will be limited to a discussion of transcriptional regulation of the activity of mF-0 in a variety of in vitro and in vivo systems and of evidence suggesting that expression of the five TGF-ps is under different celland tissue-specific transcriptional control.
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Inhibition of the chondrocyte phenotype by retinoic acid involves upregulation of metalloprotease genes independent of TGF-β
R. Tracy Ballock,Ahlke Heydemann,Lalage M. Wakefield,Kathleen C. Flanders,Anita B. Roberts,Michael B. Sporn +5 more
TL;DR: It is shown that inhibition of expression of the cartilage phenotype by retinoic acid in epiphyseal chondrocytes is associated with positive regulation of AP‐1 responsive metalloprotease genes, as well as induction of gene expression for the two components of the transcription factor AP‐ 1, c‐fos and c‐jun.
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The synthetic triterpenoid CDDO-methyl ester delays estrogen receptor-negative mammary carcinogenesis in polyoma middle T mice
Kim M. Tran,Renee Risingsong,Darlene B. Royce,Charlotte R. Williams,Michael B. Sporn,Karen T. Liby +5 more
TL;DR: Activity of the methyl ester derivative of the synthetic triterpenoid, 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid (CDDO-Me) is tested in a relevant model of estrogen receptor–negative breast cancer, the polyoma-middle T (PyMT), in which the oncoprotein drives carcinogenesis.
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RNA metabolism in tracheal epithelium: alteration in hamsters deficient in vitamin A.
David G. Kaufman,Mary S. Baker,Joseph A. M. Smith,William R. Henderson,Curtis C. Harris,Michael B. Sporn,Umberto Saffiotti +6 more
TL;DR: The electrophoretic pattern of RNA molecules that are synthesised in vitro in tracheal epithelium from hamsters deficient in vitamin A differs from that of RNA synthesized in normal, pair-fed control hamsters.