M
Michael B. Sporn
Researcher at Dartmouth College
Publications - 561
Citations - 96644
Michael B. Sporn is an academic researcher from Dartmouth College. The author has contributed to research in topics: Transforming growth factor & Transforming growth factor beta. The author has an hindex of 157, co-authored 559 publications receiving 94605 citations. Previous affiliations of Michael B. Sporn include Cornell University & Reata Pharmaceuticals.
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Journal Article
Inhibitory Effect of 13-cis-Retinoic Acid on Urinary Bladder Carcinogenesis Induced in C57BL/6 Mice by N-Butyl-N-(4-hydroxybutyl)nitrosamine
Peter J. Becci,Henry J. Thompson,Clinton J. Grubbs,Robert A. Squire,Charles C. Brown,Michael B. Sporn,Richard C. Moon +6 more
TL;DR: It is indicated that 13-cis-retinoic acid reduced not only the severity of highly invasive urinary bladder carcinomas but also the incidence of such cancers.
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Localization of polyadenylic acid sequences in messenger ribonucleic acid of mammalian cells.
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Transforming growth factors (TGFs): Properties and possible mechanisms of action
George J. Todaro,Joseph E. De Larco,Charlotte M. Fryling,Patricia A. Johnson,Michael B. Sporn +4 more
TL;DR: The term "autocrine secretion" has been proposed for this type of situation where a cell secretes a hormone-like substance for which it has external cell membrane receptors and may provide a partial explanation for some aspects of tumor cell progression.
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A synthetic triterpenoid selectively inhibits the induction of matrix metalloproteinases 1 and 13 by inflammatory cytokines
Kimberlee S. Mix,John A. Mengshol,Ulrike Benbow,Matthew P. Vincenti,Michael B. Sporn,Constance E. Brinckerhoff +5 more
TL;DR: CDDO may have therapeutic potential for the inhibition of joint degradation in osteoarthritis and is demonstrated to be a novel inhibitor of M MP-1 and MMP-13 gene expression mediated by inflammatory cytokines.
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Synthetic triterpenoids prolong survival in a transgenic mouse model of pancreatic cancer.
Karen T. Liby,Darlene B. Royce,Renee Risingsong,Charlotte R. Williams,Anirban Maitra,Ralph H. Hruban,Michael B. Sporn +6 more
TL;DR: It is suggested that oleanane triterpenoids and rexinoids have the potential to prevent pancreatic cancer.