M
Michael B. Sporn
Researcher at Dartmouth College
Publications - 561
Citations - 96644
Michael B. Sporn is an academic researcher from Dartmouth College. The author has contributed to research in topics: Transforming growth factor & Transforming growth factor beta. The author has an hindex of 157, co-authored 559 publications receiving 94605 citations. Previous affiliations of Michael B. Sporn include Cornell University & Reata Pharmaceuticals.
Papers
More filters
Journal ArticleDOI
Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-imidazolide.
Soona Shin,Junko Wakabayashi,Melinda S. Yates,Nobunao Wakabayashi,Patrick M. Dolan,Susan Aja,Karen T. Liby,Michael B. Sporn,Masayuki Yamamoto,Thomas W. Kensler +9 more
TL;DR: It is indicated that CDDO-Im is an exceedingly potent agent for preventing obesity, and the Nrf2 pathway is identified as a novel target for management of obesogenesis.
Journal ArticleDOI
Anti-inflammatory Triterpenoid Blocks Immune Suppressive Function of MDSCs and Improves Immune Response in Cancer
Srinivas Nagaraj,Je In Youn,Hannah Weber,Cristina Iclozan,Lily Lu,Matthew J. Cotter,Colin J. Meyer,Carlos Becerra,Mayer Fishman,Scott J. Antonia,Michael B. Sporn,Karen T. Liby,Bhupendra Rawal,Ji-Hyun Lee,Dmitry I. Gabrilovich +14 more
TL;DR: CDDO-Me abrogated the immune suppressive effect of MDSCs and improved immune responses in tumor-bearing mice and cancer patients and may represent an attractive therapeutic option by enhancing the effect of cancer immunotherapy.
Journal Article
Synergistic interaction of two classes of transforming growth factors from murine sarcoma cells.
Mario A. Anzano,Anita B. Roberts,Chester A. Meyers,Akira Komoriya,Lois C. Lamb,Joseph A. M. Smith,Michael B. Sporn +6 more
TL;DR: It is suggested that TGF beta may be an important mediator of the known effects of both TGF alpha and EGF on neoplastic transformation, and chemically modified analogs of EGF also potentiate TGFbeta activity to the extent that they bind to the EGF receptor.
Journal ArticleDOI
Promoter Sequences of the Human Transforming Growth Factor-β1 Gene Responsive to Transforming Growth Factor-β1 Autoinduction
TL;DR: Seven distinct factors present in nuclear extracts from A-549 cells interact with the sequences between -454 and -323, strongly supporting the involvement of sequence-specific transcription factors in the transcriptional autoactivation of the human TGF-beta 1 gene.