M
Michael B. Sporn
Researcher at Dartmouth College
Publications - 561
Citations - 96644
Michael B. Sporn is an academic researcher from Dartmouth College. The author has contributed to research in topics: Transforming growth factor & Transforming growth factor beta. The author has an hindex of 157, co-authored 559 publications receiving 94605 citations. Previous affiliations of Michael B. Sporn include Cornell University & Reata Pharmaceuticals.
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Mechanism of action of retinoids
TL;DR: It is shown that retinoic acid greatly inhibits the anchorage-independent growth of a rat fibroblast cell line that has been transfected with the c-myc gene, particularly when these cells are stimulated by the combination of platelet-derived growth factor and transforming growth factor-beta.
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Transforming growth factor beta. A biologic chorioretinal glue.
William E. Smiddy,Bert M. Glaser,William R. Green,Thomas B. Connor,Anita B. Roberts,Lucas R,Michael B. Sporn +6 more
TL;DR: It is suggested that TGF-beta may have a potential role as an alternative means for inducing a chorioretinal adhesion in the treatment of retinal tears and demonstrate intraocular in vivo bioactivity of T GF-beta.
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Regulation of the transforming growth factor-β1 and -β3 promoters by transcription factor Spl
Andrew G. Geiser,K J Busam,Seong-Jin Kim,Robert Lafyatis,Michael A. O'Reilly,Renée Webbink,Anita B. Roberts,Michael B. Sporn +7 more
TL;DR: In this paper, a Drosophila melanogaster cell culture system was employed to examine expression levels of pTGF-β::cat constructs coexpressed with an Spl expression plasmid in a cell background devoid of any Spl homolog.
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Stimulation of DNA synthesis in cultured primary human mesothelial cells by specific growth factors.
Edward Gabrielson,Brenda I. Gerwin,Curtis C. Harris,Anita B. Roberts,Michael B. Sporn,John F. Lechner +5 more
TL;DR: Stimulation of growth by PDGF and TGF‐β1 is unusual for an epithelial cell type, and indicates that mesothelial cells have growth regulatory properties similar to connective tissue cells.
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Vitamin A deficiency enhances binding of benzo(a)pyrene to tracheal epithelial DNA
Valerio M. Genta,David G. Kaufman,Curtis C. Harris,Joseph A. M. Smith,Michael B. Sporn,Umberto Saffiotti +5 more
TL;DR: The binding of tritiated benzo(a)pyrene (3H-BP) to DNA in tracheal epithelial cells of normal and vitamin A deficient hamsters is studied to study the possible relationship of the altered state of differentiation of respiratory epithelium to chemical carcinogenesis in this tissue.