Michael B. Sporn

TL;DR: Of these new compounds, CDDO conjugates with alanine, valine, and serine are nearly equipotent to CDDO-ethyl amide, a triterpenoid with promising biological activity in numerous disease models.

TL;DR: The data suggest that correct folding of the highly conserved C terminus of TGF-beta 1 is critical for subsequent proteolytic cleavage and glycosylation at sites that are quite distant in the primary sequence, and molecular strategies for the generation of T GF-beta antagonists or superagonists should avoid extensive modification of this region of the molecule.

TL;DR: It is shown that these novel derivatives were more effective agents than bexarotene for preventing lung carcinogenesis induced by a carcinogen and have an improved safety profile, and novel pyrimidinyl (Py) analogues of two known chemopreventive rexinoids are evaluated in a new paradigm.

TL;DR: The results indicate a complex pattern of transcriptional regulation of the chicken TGF-beta 3 gene and suggest that differences in the regulation of expression of the genes for mammalian and avian TGF -beta 3 may result in part from the unique structure of their 5'-flanking regions.

TL;DR: The present invention provides triterpenoids produced from natural compounds such as oleanolic acid, ursolic acid and betulinic acid, and hederagenin this article.