M
Michael B. Sporn
Researcher at Dartmouth College
Publications - 561
Citations - 96644
Michael B. Sporn is an academic researcher from Dartmouth College. The author has contributed to research in topics: Transforming growth factor & Transforming growth factor beta. The author has an hindex of 157, co-authored 559 publications receiving 94605 citations. Previous affiliations of Michael B. Sporn include Cornell University & Reata Pharmaceuticals.
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Chemoprevention of cancer
TL;DR: The importance of developing totally new classes of chemopreventive agents is stressed, with particular emphasis on the potential usefulness of new synthetic triterpenoids derived from naturally occurring molecules.
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Retraction: The triterpenoid CDDO-Imidazolide induces apoptosis and enhances fludarabine-induced apoptosis of CLL B-cells.
Irene M. Pedersen,Juan M. Zapata,Temesgen Samuel,Fiona L. Scott,Guy S. Salvesen,Tadashi Honda,Gordon W. Gribble,Nanjoo Suh,Michael B. Sporn,Thomas J. Kipps,John C. Reed +10 more
TL;DR: The triterpenoid CDDO-Imidazolide induces apoptosis and enhances fludarabine-induced apoptosis of CLL B-cells and this paper retracts this prepublished paper.
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Studies on the allosteric properties of nuclear exoribonuclease from Ehrlich ascites tumor.
Journal Article
The E1A Oncogene Induces Resistance to the Effects of 1,25-Dihydroxyvitamin D3 on Inhibition of Growth of Mouse Keratinocytes
K. Park,Hyun W. Bae,A. Heydemann,Anita B. Roberts,G. P. Dotto,Michael B. Sporn,Seong-Jin Kim +6 more
TL;DR: The results suggest that one of the mechanisms for acquisition of 1,25-Dihydroxyvitamin D3 resistance induced by E1A may involve loss of vitamin D receptor inducibility by 1, 25-(OH)2D3.
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Nrf2 protects against radiation-induced oral mucositis via antioxidation and keratin layer thickening.
Shun Wakamori,Keiko Taguchi,Yuki Nakayama,Akira Ohkoshi,Michael B. Sporn,Takenori Ogawa,Yukio Katori,Masayuki Yamamoto +7 more
TL;DR: In this article , a system for γ-ray exposure of restricted areas and irradiated the tongues of model mice with Nrf2 and Keap1 loss-of-function was presented.