M
Michael B. Sporn
Researcher at Dartmouth College
Publications - 561
Citations - 96644
Michael B. Sporn is an academic researcher from Dartmouth College. The author has contributed to research in topics: Transforming growth factor & Transforming growth factor beta. The author has an hindex of 157, co-authored 559 publications receiving 94605 citations. Previous affiliations of Michael B. Sporn include Cornell University & Reata Pharmaceuticals.
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Purification by Reverse-Phase High-Performance Liquid Chromatography of an Epidermal Growth Factor-Dependent Transforming Growth Factor
TL;DR: Transforming growth factors are low molecular weight, acid-stable polypeptides that confer a malignant phenotype on nonneoplastic cells that are isolated by acid/ethanol extraction, Bio-Gel P-30 chromatography, and reverse-phase high-performance liquid chromatography.
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Overexpression of transforming growth factor-beta in transgenic mice carrying the human T-cell lymphotropic virus type I tax gene.
Seong-Jin Kim,Thomas S. Winokur,Hy De Lee,David Danielpour,Kyung Young Kim,Andrew G. Geiser,Lian Sheng Chen,Michael B. Sporn,Anita B. Roberts,Gilbert Jay +9 more
TL;DR: TGF-beta 1 significantly stimulated the incorporation of tritiated thymidine into one of three cell lines derived from neurofibromas of tax-transgenic mice, which suggests that the excessive production of TGF- beta 1 may play a role in tumorigenesis and that these mice may serve as a useful model for studying the biological effects of T GF-beta in vivo.
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Characterization of distinct functional domains of transforming growth factor beta
James K. Burmester,Su Wen Qian,Anita B. Roberts,Alison J. Huang,Supavadee Amatayakul-Chantler,Laurent Suardet,Nicolas Odartchenko,Joseph A. Madri,Michael B. Sporn +8 more
TL;DR: Two distinct functional domains of TGF-beta are identified involved in determining the biological potencies and functions of the molecule and are important for determining the potency of T GF-beta to inhibit growth of the LS513 human colorectal cancer cell line.
Journal Article
Expression of Sulfated Glycoprotein 2 Is Associated with Carcinogenesis Induced by N-Nitroso-N-methylurea in Rat Prostate and Seminal Vesicle
Kenji Kadomatsu,Mario A. Anzano,Michael V. Slayter,Thomas S. Winokur,Joseph M. Smith,Michael B. Sporn +5 more
TL;DR: High levels of SGP-2 expression are found in the epithelial component of carcinomas of the prostate and seminal vesicle after initiation with N-nitroso-N-methylurea and promotion with testosterone propionate.
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Clinical prevention of recurrence of colorectal adenomas by the combination of difluoromethylornithine and sulindac: an important milestone.
Michael B. Sporn,Waun Ki Hong +1 more
TL;DR: The spectacular clinical results reported by Meyskens, Gerner and colleagues in a lead article of this very first issue of this new AACR journal on cancer prevention represent a landmark advance in efforts to stop the current worldwide epidemic of cancer deaths.