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Michael B. Sporn

Researcher at Dartmouth College

Publications -  561
Citations -  96644

Michael B. Sporn is an academic researcher from Dartmouth College. The author has contributed to research in topics: Transforming growth factor & Transforming growth factor beta. The author has an hindex of 157, co-authored 559 publications receiving 94605 citations. Previous affiliations of Michael B. Sporn include Cornell University & Reata Pharmaceuticals.

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Retinoid X receptor and peroxisome proliferator-activated receptor-gamma agonists cooperate to inhibit matrix metalloproteinase gene expression

Peter S Burrage, +4 more
- 01 Dec 2008 - 
TL;DR: The PPARγ and RXR ligands rosiglitazone and LG268 may act through similar mechanisms, inhibiting M MP-1 and MMP-13 transcription by combinatorial treatment with RXR and PParγ ligands.
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Role for autocrine TGF-beta 1 in regulating differentiation of a human leukemic cell line toward osteoclast-like cells.

Gianna Fiorelli, +9 more
- 01 Sep 1994 - 
TL;DR: It is demonstrated that a recently cloned human leukemic cell line (FLG 29.1 cells) synthesize and secrete TGF‐β1 and that exogenous or autocrine TGF•β1 can induce the same features of osteoclastic‐like cells, exerting its effects through the binding to T GF‐β specific receptors.
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Novel synthetic pyridyl analogues of CDDO-Imidazolide are useful new tools in cancer prevention

Martine Cao, +6 more
- 01 Oct 2015 - 
TL;DR: Drugs tested for prevention in a highly relevant mouse lung cancer model were as effective as CDDO-Im for reducing the size and the severity of the lung tumors and pharmacokinetic studies performed in vitro in human plasma and in vivo showed that each new analogue was more stable than CDDO -Im.
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Regulation of expression of transforming growth factor-β2 by transforming growth factor-β isoforms is dependent upon cell type

Michael A. O'Reilly, +3 more
- 01 Jan 1992 - 
TL;DR: The effect of three different isoforms of transforming growth factor-β (TGF-β) on the expression of TGF- β2 mRNA was studied in several continuous tumor cell lines and a similar 2–3 fold increase in the level of secreted T GF-β2 was observed following treatment of A549 cells.
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Evidence for Differential Regulation of TGFβ1 and TGFβ2 Expression in Vivo by Sandwich Enzyme‐linked Immunosorbent Assays

David Danielpour, +5 more
- 01 Jun 1990 - 
TL;DR: The results from this study demonstrate that TGFpl is the method of choice for rapid, accurate, and precise measurement of mFD1 and E F P 2 in complex biological fluids.