M
Michael Cornell
Researcher at University of Manchester
Publications - 12
Citations - 4704
Michael Cornell is an academic researcher from University of Manchester. The author has contributed to research in topics: Genome & Notch signaling pathway. The author has an hindex of 12, co-authored 12 publications receiving 4490 citations. Previous affiliations of Michael Cornell include University of Maryland, Baltimore.
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Journal ArticleDOI
Comparative assessment of large-scale data sets of protein-protein interactions.
Christian von Mering,Roland Krause,Berend Snel,Michael Cornell,Stephen G. Oliver,Stanley Fields,Peer Bork +6 more
TL;DR: Comprehensive protein–protein interaction maps promise to reveal many aspects of the complex regulatory network underlying cellular function and are compared with each other and with a reference set of previously reported protein interactions.
Journal ArticleDOI
Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88
Herman Jan Pel,Johannes H. de Winde,Johannes H. de Winde,David B. Archer,Paul S. Dyer,Gerald Hofmann,Peter J. Schaap,Geoffrey Turner,Ronald P. de Vries,Richard Albang,Kaj Albermann,Mikael Rørdam Andersen,Jannick Dyrløv Bendtsen,Jacques A.E. Benen,Marco A. van den Berg,Stefaan Breestraat,Mark X. Caddick,Roland Contreras,Michael Cornell,Pedro M. Coutinho,Etienne Danchin,Alfons J. M. Debets,Peter J. T. Dekker,Piet W.M. van Dijck,Alard Van Dijk,Lubbert Dijkhuizen,Arnold J. M. Driessen,Christophe d'Enfert,Steven Geysens,Coenie Goosen,Gert S.P. Groot,Piet W. J. de Groot,Thomas Guillemette,Bernard Henrissat,Marga Herweijer,Johannes Petrus Theodorus Wilhelmus Van Den Hombergh,Cees A. M. J. J. van den Hondel,René T. J. M. van der Heijden,Rachel M. van der Kaaij,Frans M. Klis,Harrie J. Kools,Christian P. Kubicek,Patricia Ann van Kuyk,Jürgen Lauber,Xin Lu,Marc J. E. C. van der Maarel,Rogier Meulenberg,Hildegard Henna Menke,Martin Mortimer,Jens Nielsen,Stephen G. Oliver,Maurien M.A. Olsthoorn,K. Pal,K. Pal,Noël Nicolaas Maria Elisabeth Van Peij,Arthur F. J. Ram,Ursula Rinas,Johannes Andries Roubos,Cornelis Maria Jacobus Sagt,Monika Schmoll,Jibin Sun,David W. Ussery,János Varga,Wouter Vervecken,Peter J.J. Van De Vondervoort,Holger Wedler,Han A. B. Wösten,An-Ping Zeng,Albert J. J. van Ooyen,Jaap Visser,Hein Stam +70 more
TL;DR: The filamentous fungus Aspergillus niger is widely exploited by the fermentation industry for the production of enzymes and organic acids, particularly citric acid, and the sequenced genome revealed a large number of major facilitator superfamily transporters and fungal zinc binuclear cluster transcription factors.
Journal ArticleDOI
Growth control of the eukaryote cell: a systems biology study in yeast
Juan I. Castrillo,Leo A. H. Zeef,David C. Hoyle,Nianshu Zhang,Andrew Hayes,David C. J. Gardner,Michael Cornell,June Petty,Luke Hakes,Leanne Wardleworth,Bharat M. Rash,Marie Brown,Warwick B. Dunn,David Broadhurst,Kerry O'Donoghue,Svenja Hester,Tom Dunkley,Sarah R. Hart,Neil Swainston,Peter Li,Simon J. Gaskell,Norman W. Paton,Kathryn S. Lilley,Douglas B. Kell,Stephen G. Oliver +24 more
TL;DR: This work constitutes a first comprehensive systems biology study on growth-rate control in the eukaryotic cell and has direct implications for advanced studies on cell growth, in vivo regulation of metabolic fluxes for comprehensive metabolic engineering, and for the design of genome-scale systems biology models of the eUKaryoticcell.
Journal ArticleDOI
Regulation of notch endosomal sorting and signaling by Drosophila Nedd4 family proteins.
Marian B. Wilkin,Ann Marie Carbery,Maggy Fostier,Hanna Aslam,Sabine L. Mazaleyrat,Jenny Higgs,Anna Myat,Dana A P Evans,Michael Cornell,Martin Baron +9 more
TL;DR: This work shows in Drosophila that Notch signaling is limited by the activity of two Nedd4 family HECT domain proteins, Suppressor of deltex [Su(dx)] and DNedd4, and proposes a model in which endocytic sorting of Notch mediates a decision between its activation and downregulation.
Journal ArticleDOI
The Drosophila melanogaster Suppressor of deltex gene, a regulator of the Notch receptor signaling pathway, is an E3 class ubiquitin ligase.
Michael Cornell,Dana A P Evans,Robert S. Mann,Maggy Fostier,M. Flasza,M. Monthatong,Spyros Artavanis-Tsakonas,Martin Baron +7 more
TL;DR: Overexpression of Su( dx) results in ectopic vein differentiation, wing margin loss, and wing growth phenotypes and enhances the phenotypes of loss-of-function mutations in Notch, evidence that supports the conclusion that Su(dx) has a role in the downregulation of Notch signaling.