Michael Snyder

TL;DR: The results show that both the background and the binding sites need to have a markedly nonuniform distribution in order to correctly model the observed ChIP-seq data, with, for instance, the background tag counts modeled by a gamma distribution.

TL;DR: Analyzing the temporal order of binding of several key factors involved in the salt response of yeast to their target genes reveals a complex dynamic and hierarchical circuit in which specific combinations of transcription factors target distinct sets of genes at discrete times to coordinate a rapid and important biological response.

TL;DR: It is reported that Rim15 coordinates transcription with posttranscriptional mRNA protection by phosphorylating the paralogous Igo1 and Igo2 proteins, which shelters newly expressed mRNAs from degradation via the 5'-3' mRNA decay pathway, thereby enabling their proper translation during initiation of the G(0) program.

TL;DR: A network framework for analyzing multi-level regulation in higher eukaryotes based on systematic integration of various high-throughput datasets is presented, finding that transcription factors downstream of the hierarchy distinguish themselves by expressing more uniformly at various tissues, have more interacting partners, and are more likely to be essential.

TL;DR: A role for Rom2p in both polarized morphogenesis and functions of the microtubule cytoskeleton is suggested, as high-copy number plasmids containing either ROM2 or RHO2 suppress the temperature-sensitive growth defects of cik1 delta and kar3 delta strains.