M
Michael Snyder
Researcher at Stanford University
Publications - 938
Citations - 150929
Michael Snyder is an academic researcher from Stanford University. The author has contributed to research in topics: Gene & Genome. The author has an hindex of 169, co-authored 840 publications receiving 130225 citations. Previous affiliations of Michael Snyder include Wyss Institute for Biologically Inspired Engineering & Public Health Research Institute.
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Journal ArticleDOI
Sequence features and chromatin structure around the genomic regions bound by 119 human transcription factors.
Jie Wang,Jiali Zhuang,Sowmya Iyer,Sowmya Iyer,Xinying Lin,Troy W. Whitfield,Melissa C. Greven,Brian G. Pierce,Xianjun Dong,Anshul Kundaje,Yong Cheng,Oliver J. Rando,Ewan Birney,Richard M. Myers,William Stafford Noble,Michael Snyder,Zhiping Weng +16 more
TL;DR: An integrative analysis centered around 457 ChIP-seq data sets on 119 human TFs generated by the ENCODE Consortium identified highly enriched sequence motifs in most data sets, revealing new motifs and validating known ones.
Journal ArticleDOI
Analysis of yeast protein kinases using protein chips.
Heng Zhu,James F. Klemic,Swan Chang,Paul Bertone,Antonio Casamayor,Kathryn G. Klemic,David M. Smith,Mark Gerstein,Mark A. Reed,Michael Snyder +9 more
TL;DR: A novel protein chip technology is developed that allows the high-throughput analysis of biochemical activities, and this approach is used to analyse nearly all of the protein kinases from Saccharomyces cerevisiae, finding many novel activities and that a large number ofprotein kinases are capable of phosphorylating tyrosine.
Journal ArticleDOI
Topologically associating domains are stable units of replication-timing regulation
Benjamin D. Pope,Tyrone Ryba,Vishnu Dileep,Feng Yue,Weisheng Wu,Olgert Denas,Daniel L. Vera,Yanli Wang,R. Scott Hansen,Theresa K. Canfield,Robert E. Thurman,Yong Cheng,Günhan Gülsoy,Jonathan H. Dennis,Michael Snyder,John A. Stamatoyannopoulos,James Taylor,Ross C. Hardison,Tamer Kahveci,Bing Ren,David M. Gilbert +20 more
TL;DR: It is demonstrated that, collectively, replication domain boundaries share a near one-to-one correlation with TAD boundaries, whereas within a cell type, adjacent TADs that replicate at similar times obscure replicationdomain boundaries, largely accounting for the previously reported lack of alignment.
Journal ArticleDOI
Unlocking the secrets of the genome
Susan E. Celniker,Laura A.L. Dillon,Mark Gerstein,Kristin C. Gunsalus,Steven Henikoff,Gary H. Karpen,Manolis Kellis,Eric C. Lai,Jason D. Lieb,David M. MacAlpine,Gos Micklem,Fabio Piano,Michael Snyder,Lincoln Stein,Kevin P. White,Robert H. Waterston +15 more
TL;DR: In this paper, a look at the crucial functional elements of fly and worm genomes could change the way genetic information produces complex organisms, and the results showed that the functional elements were crucial for the evolution of complex organisms.
Journal Article
Unlocking the Secrets of the Genome
Susan E. Celniker,Laura A.L. Dillon,Mark Gerstein,Kristin C. Gunsalus,Steven Henikoff,Gary H. Karpen,Manolis Kellis,Eric C. Lai,Jason D. Lieb,David M. MacAlpine,Gos Micklem,Fabio Piano,Michael Snyder,Lincoln Stein,Kevin P. White,Robert H. Waterston +15 more
TL;DR: This issue, modENCODE team members outline their plan of campaign and data from the project are to be made available on http://www.modencode.org and elsewhere as the work progresses.